prikaz prve stranice dokumenta Botulinum toxin's axonal transport from periphery to the spinal cord
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Scientific paper - Original scientific paper
Botulinum toxin's axonal transport from periphery to the spinal cord
Neurochemistry International, 61 (2012), 2; 236-239. https://doi.org/10.1016/j.neuint.2012.05.001
Matak, Ivica; Riederer, Peter; Lacković, Zdravko

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Matak, I., Riederer, P. & Lacković, Z. (2012). Botulinum toxin's axonal transport from periphery to the spinal cord. Neurochemistry International, 61. (2), 236-239. doi: 10.1016/j.neuint.2012.05.001

Matak, Ivica, et al. "Botulinum toxin's axonal transport from periphery to the spinal cord." Neurochemistry International, vol. 61, no. 2, 2012, pp. 236-239. https://doi.org/10.1016/j.neuint.2012.05.001

Matak, Ivica, Peter Riederer and Zdravko Lacković. "Botulinum toxin's axonal transport from periphery to the spinal cord." Neurochemistry International 61, no. 2 (2012): 236-239. https://doi.org/10.1016/j.neuint.2012.05.001

Matak, I., Riederer, P. and Lacković, Z. (2012) 'Botulinum toxin's axonal transport from periphery to the spinal cord', Neurochemistry International, 61(2), pp. 236-239. doi: 10.1016/j.neuint.2012.05.001

Matak I, Riederer P, Lacković Z. Botulinum toxin's axonal transport from periphery to the spinal cord. Neurochemistry International [Internet]. 2012 July [cited 2024 December 26];61(2):236-239. doi: 10.1016/j.neuint.2012.05.001

I. Matak, P. Riederer and Z. Lacković, "Botulinum toxin's axonal transport from periphery to the spinal cord", Neurochemistry International, vol. 61, no. 2, pp. 236-239, July 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:651272. [Accessed: 26 December 2024]

Metadata
Title (english)Botulinum toxin's axonal transport from periphery to the spinal cord
AuthorIvica Matak
AuthorPeter Riederer
AuthorZdravko Lacković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Axonal transport of enzymatically active botulinum toxin A (BTX-A) from periphery to the CNS has been described in facial and trigeminal nerve, leading to cleavage of synaptosomal-associated protein 25 (SNAP-25) in central nuclei. Aim of present study was to examine the existence of axonal transport of peripherally applied BTX-A to spinal cord via sciatic nerve. We employed BTX-A-cleaved SNAP-25 immunohistochemistry of lumbar spinal cord after intramuscular and subcutaneous hind limb injections, and intraneural BTX-A sciatic nerve injections. Truncated SNAP-25 in ipsilateral spinal cord ventral horns and dorsal horns appeared after single peripheral BTX-A administrations, even at low intramuscular dose applied (5 U/kg). Cleaved SNAP-25 appearance in the spinal cord after BTX-A injection into the sciatic nerve was prevented by proximal intrasciatic injection of colchicine (5 mM, 2 μl). Cleaved SNAP-25 in ventral horn, using choline-acetyltransferase (ChAT) double labeling, was localized within cholinergic neurons. These results extend the recent findings on BTX-A retrograde axonal transport in facial and trigeminal nerve. Appearance of truncated SNAP-25 in spinal cord following low-dose peripheral BTX-A suggest that the axonal transport of BTX-A occurs commonly following peripheral application.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleNeurochemistry International
Numberingvol. 61, no. 2, pp. 236-239
p-ISSN0197-0186
DOIhttps://doi.org/10.1016/j.neuint.2012.05.001
URN:NBNurn:nbn:hr:105:651272
Publication2012-07
Document URLhttps://doi.org/10.1016/j.neuint.2012.05.001
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:34:56