prikaz prve stranice dokumenta Botulinum toxin's axonal transport from periphery to the spinal cord
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Botulinum toxin's axonal transport from periphery to the spinal cord
Neurochemistry International, 61 (2012), 2; 236-239. https://doi.org/10.1016/j.neuint.2012.05.001
Matak, Ivica; Riederer, Peter; Lacković, Zdravko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Matak, I., Riederer, P. i Lacković, Z. (2012). Botulinum toxin's axonal transport from periphery to the spinal cord. Neurochemistry International, 61. (2), 236-239. doi: 10.1016/j.neuint.2012.05.001

Matak, Ivica, et al. "Botulinum toxin's axonal transport from periphery to the spinal cord." Neurochemistry International, vol. 61, br. 2, 2012, str. 236-239. https://doi.org/10.1016/j.neuint.2012.05.001

Matak, Ivica, Peter Riederer i Zdravko Lacković. "Botulinum toxin's axonal transport from periphery to the spinal cord." Neurochemistry International 61, br. 2 (2012): 236-239. https://doi.org/10.1016/j.neuint.2012.05.001

Matak, I., Riederer, P. i Lacković, Z. (2012) 'Botulinum toxin's axonal transport from periphery to the spinal cord', Neurochemistry International, 61(2), str. 236-239. doi: 10.1016/j.neuint.2012.05.001

Matak I, Riederer P, Lacković Z. Botulinum toxin's axonal transport from periphery to the spinal cord. Neurochemistry International [Internet]. 07.2012. [pristupljeno 25.11.2024.];61(2):236-239. doi: 10.1016/j.neuint.2012.05.001

I. Matak, P. Riederer i Z. Lacković, "Botulinum toxin's axonal transport from periphery to the spinal cord", Neurochemistry International, vol. 61, br. 2, str. 236-239, Srpanj 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:651272. [Citirano: 25.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:651272
Podaci o radu
Naslov (engleski)Botulinum toxin's axonal transport from periphery to the spinal cord
AutorIvica Matak
AutorPeter Riederer
AutorZdravko Lacković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Axonal transport of enzymatically active botulinum toxin A (BTX-A) from periphery to the CNS has been described in facial and trigeminal nerve, leading to cleavage of synaptosomal-associated protein 25 (SNAP-25) in central nuclei. Aim of present study was to examine the existence of axonal transport of peripherally applied BTX-A to spinal cord via sciatic nerve. We employed BTX-A-cleaved SNAP-25 immunohistochemistry of lumbar spinal cord after intramuscular and subcutaneous hind limb injections, and intraneural BTX-A sciatic nerve injections. Truncated SNAP-25 in ipsilateral spinal cord ventral horns and dorsal horns appeared after single peripheral BTX-A administrations, even at low intramuscular dose applied (5 U/kg). Cleaved SNAP-25 appearance in the spinal cord after BTX-A injection into the sciatic nerve was prevented by proximal intrasciatic injection of colchicine (5 mM, 2 μl). Cleaved SNAP-25 in ventral horn, using choline-acetyltransferase (ChAT) double labeling, was localized within cholinergic neurons. These results extend the recent findings on BTX-A retrograde axonal transport in facial and trigeminal nerve. Appearance of truncated SNAP-25 in spinal cord following low-dose peripheral BTX-A suggest that the axonal transport of BTX-A occurs commonly following peripheral application.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaNeurochemistry International
Brojčani podacivol. 61, br. 2, str. 236-239
p-ISSN0197-0186
DOIhttps://doi.org/10.1016/j.neuint.2012.05.001
URN:NBNurn:nbn:hr:105:651272
Datum objave publikacije2012-07
URL dokumentahttps://doi.org/10.1016/j.neuint.2012.05.001
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:34:56