prikaz prve stranice dokumenta Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients
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Scientific paper - Original scientific paper
Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients
Croatian Medical Journal, 53 (2012), 4; 321-7. https://doi.org/10.3325/cmj.2012.53.321
Pećina-Šlaus, Nives; Zeljko, Martina; Pećina, Hrvoje Ivan; Nikuševa Martić, Tamara; Bačić, Niko; Tomas, Davor; Hrašćan, Reno

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Pećina Šlaus, N., Zeljko, M., Pećina, H. I., Nikuševa Martić, T., Bačić, N., Tomas, D. & Hrašćan, R. (2012). Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients. Croatian Medical Journal, 53. (4), 321-7. doi: 10.3325/cmj.2012.53.321

Pećina Šlaus, Nives, et al. "Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients." Croatian Medical Journal, vol. 53, no. 4, 2012, pp. 321-7. https://doi.org/10.3325/cmj.2012.53.321

Pećina Šlaus, Nives, Martina Zeljko, Hrvoje Ivan Pećina, Tamara Nikuševa Martić, Niko Bačić, Davor Tomas and Reno Hrašćan. "Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients." Croatian Medical Journal 53, no. 4 (2012): 321-7. https://doi.org/10.3325/cmj.2012.53.321

Pećina Šlaus, N., et al. (2012) 'Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients', Croatian Medical Journal, 53(4), pp. 321-7. doi: 10.3325/cmj.2012.53.321

Pećina Šlaus N, Zeljko M, Pećina HI, Nikuševa Martić T, Bačić N, Tomas D, and sur.. Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients. Croatian Medical Journal [Internet]. 2012 August [cited 2024 November 22];53(4):321-7. doi: 10.3325/cmj.2012.53.321

N. Pećina Šlaus, et al., "Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients", Croatian Medical Journal, vol. 53, no. 4, pp. 321-7, August 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:598438. [Accessed: 22 November 2024]

Metadata
Title (english)Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients
AuthorNives Pećina-Šlaus
AuthorMartina Zeljko
AuthorHrvoje Ivan Pećina
AuthorTamara Nikuševa Martić
AuthorNiko Bačić
AuthorDavor Tomas
AuthorReno Hrašćan
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To identify gross deletions in the NF2 gene in a panel of schwannomas from Croatian patients in order to establish their frequencies in Croatian population. ----- METHODS: Changes of the NF2 gene were tested by polymerase chain reaction/loss of heterozygosity (LOH) using two microsatellite markers, D22S444 and D22S929. ----- RESULTS: The analysis with both markers demonstrated that 43.75% of schwannomas exhibited LOH of the NF2 gene. The D22S444 region exhibited 45.5% of LOHs and the D22S929 region exhibited 14.3% of LOHs. Four LOHs were found in Antoni B, 2 in Antoni A, and 1 in Antoni A and B type tumors. ----- CONCLUSION: The frequency of changes observed in Croatian patients is broadly similar to that reported in other populations and thus confirms the existing hypothesis regarding the tumorigenesis of schwannomas and contributes to schwannoma genetic profile helping us to better understand its etiology and treatment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 53, no. 4, pp. 321-7
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2012.53.321
URN:NBNurn:nbn:hr:105:598438
Publication2012-08
Document URLhttp://www.cmj.hr/2012/53/4/22911524.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:36:53