prikaz prve stranice dokumenta Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients
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Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients
Croatian Medical Journal, 53 (2012), 4; 321-7. https://doi.org/10.3325/cmj.2012.53.321
Pećina-Šlaus, Nives; Zeljko, Martina; Pećina, Hrvoje Ivan; Nikuševa Martić, Tamara; Bačić, Niko; Tomas, Davor; Hrašćan, Reno

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Pećina Šlaus, N., Zeljko, M., Pećina, H. I., Nikuševa Martić, T., Bačić, N., Tomas, D. i Hrašćan, R. (2012). Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients. Croatian Medical Journal, 53. (4), 321-7. doi: 10.3325/cmj.2012.53.321

Pećina Šlaus, Nives, et al. "Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients." Croatian Medical Journal, vol. 53, br. 4, 2012, str. 321-7. https://doi.org/10.3325/cmj.2012.53.321

Pećina Šlaus, Nives, Martina Zeljko, Hrvoje Ivan Pećina, Tamara Nikuševa Martić, Niko Bačić, Davor Tomas i Reno Hrašćan. "Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients." Croatian Medical Journal 53, br. 4 (2012): 321-7. https://doi.org/10.3325/cmj.2012.53.321

Pećina Šlaus, N., et al. (2012) 'Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients', Croatian Medical Journal, 53(4), str. 321-7. doi: 10.3325/cmj.2012.53.321

Pećina Šlaus N, Zeljko M, Pećina HI, Nikuševa Martić T, Bačić N, Tomas D, i sur.. Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients. Croatian Medical Journal [Internet]. 08.2012. [pristupljeno 16.05.2024.];53(4):321-7. doi: 10.3325/cmj.2012.53.321

N. Pećina Šlaus, et al., "Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients", Croatian Medical Journal, vol. 53, br. 4, str. 321-7, Kolovoz 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:598438. [Citirano: 16.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:598438
Podaci o radu
Naslov (engleski)Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients
AutorNives Pećina-Šlaus
AutorMartina Zeljko
AutorHrvoje Ivan Pećina
AutorTamara Nikuševa Martić
AutorNiko Bačić
AutorDavor Tomas
AutorReno Hrašćan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIM: To identify gross deletions in the NF2 gene in a panel of schwannomas from Croatian patients in order to establish their frequencies in Croatian population. ----- METHODS: Changes of the NF2 gene were tested by polymerase chain reaction/loss of heterozygosity (LOH) using two microsatellite markers, D22S444 and D22S929. ----- RESULTS: The analysis with both markers demonstrated that 43.75% of schwannomas exhibited LOH of the NF2 gene. The D22S444 region exhibited 45.5% of LOHs and the D22S929 region exhibited 14.3% of LOHs. Four LOHs were found in Antoni B, 2 in Antoni A, and 1 in Antoni A and B type tumors. ----- CONCLUSION: The frequency of changes observed in Croatian patients is broadly similar to that reported in other populations and thus confirms the existing hypothesis regarding the tumorigenesis of schwannomas and contributes to schwannoma genetic profile helping us to better understand its etiology and treatment.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 53, br. 4, str. 321-7
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2012.53.321
URN:NBNurn:nbn:hr:105:598438
Datum objave publikacije2012-08
URL dokumentahttp://www.cmj.hr/2012/53/4/22911524.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:36:53