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Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective
Croatian Medical Journal, 53 (2012), 4; 314-320. https://doi.org/10.3325/cmj.2012.53.314
Gundert-Remy, Ursula; Dimovski, Aleksandar; Gajović, Srećko

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Gundert Remy, U., Dimovski, A. & Gajović, S. (2012). Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective. Croatian Medical Journal, 53. (4), 314-320. doi: 10.3325/cmj.2012.53.314

Gundert Remy, Ursula, et al. "Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective." Croatian Medical Journal, vol. 53, no. 4, 2012, pp. 314-320. https://doi.org/10.3325/cmj.2012.53.314

Gundert Remy, Ursula, Aleksandar Dimovski and Srećko Gajović. "Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective." Croatian Medical Journal 53, no. 4 (2012): 314-320. https://doi.org/10.3325/cmj.2012.53.314

Gundert Remy, U., Dimovski, A. and Gajović, S. (2012) 'Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective', Croatian Medical Journal, 53(4), pp. 314-320. doi: 10.3325/cmj.2012.53.314

Gundert Remy U, Dimovski A, Gajović S. Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective. Croatian Medical Journal [Internet]. 2012 August [cited 2024 May 14];53(4):314-320. doi: 10.3325/cmj.2012.53.314

U. Gundert Remy, A. Dimovski and S. Gajović, "Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective", Croatian Medical Journal, vol. 53, no. 4, pp. 314-320, August 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:201122. [Accessed: 14 May 2024]

Metadata
Title (english)Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective
AuthorUrsula Gundert-Remy
AuthorAleksandar Dimovski
AuthorSrećko Gajović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Reviewing the past and the present status of personalized medicine, the hope and promise from several years ago was critically compared to what is really achieved to tailor the drug treatment according to the patient's individuality. The basis for consideration is what we know about the variant of the disease the patient is suffering from, and about the mechanisms influencing the plasma concentration-time profile, such as activity of metabolizing enzymes and transporters. In cancer treatment, drugs are currently selected regarding molecular properties of the cancer tissue, eg, expressing receptors such as HER2 receptor. Currently diagnostic tests are available allowing to detect somatic cell mutations that can be used to guide drug selection. Unfortunately, tumor heterogeneity and developing resistance by further mutations may limit the success of the therapy determined by molecular diagnostics. The present status can be described that in drug kinetics we know the influencing factors and we understand the mechanisms. However, only in a few cases the genetic background is the main determinant of kinetic variability, and environmental and other factors have an additional important role. Therefore, much more has to be done before we can translate the accumulating knowledge into a benefit for the patient. Only then, we can speak about personalized medicine.
Keywords (english)
Languageenglish
Publication typeOther - Discussion
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 53, no. 4, pp. 314-320
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2012.53.314
URN:NBNurn:nbn:hr:105:201122
Publication2012-08
Document URLhttp://www.cmj.hr/2012/53/4/22911523.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:36:43