prikaz prve stranice dokumenta Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective
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Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective
Croatian Medical Journal, 53 (2012), 4; 314-320. https://doi.org/10.3325/cmj.2012.53.314
Gundert-Remy, Ursula; Dimovski, Aleksandar; Gajović, Srećko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Gundert Remy, U., Dimovski, A. i Gajović, S. (2012). Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective. Croatian Medical Journal, 53. (4), 314-320. doi: 10.3325/cmj.2012.53.314

Gundert Remy, Ursula, et al. "Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective." Croatian Medical Journal, vol. 53, br. 4, 2012, str. 314-320. https://doi.org/10.3325/cmj.2012.53.314

Gundert Remy, Ursula, Aleksandar Dimovski i Srećko Gajović. "Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective." Croatian Medical Journal 53, br. 4 (2012): 314-320. https://doi.org/10.3325/cmj.2012.53.314

Gundert Remy, U., Dimovski, A. i Gajović, S. (2012) 'Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective', Croatian Medical Journal, 53(4), str. 314-320. doi: 10.3325/cmj.2012.53.314

Gundert Remy U, Dimovski A, Gajović S. Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective. Croatian Medical Journal [Internet]. 08.2012. [pristupljeno 29.04.2024.];53(4):314-320. doi: 10.3325/cmj.2012.53.314

U. Gundert Remy, A. Dimovski i S. Gajović, "Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective", Croatian Medical Journal, vol. 53, br. 4, str. 314-320, Kolovoz 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:201122. [Citirano: 29.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:201122
Podaci o radu
Naslov (engleski)Personalized medicine - where do we stand? Pouring some water into wine: a realistic perspective
AutorUrsula Gundert-Remy
AutorAleksandar Dimovski
AutorSrećko Gajović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Reviewing the past and the present status of personalized medicine, the hope and promise from several years ago was critically compared to what is really achieved to tailor the drug treatment according to the patient's individuality. The basis for consideration is what we know about the variant of the disease the patient is suffering from, and about the mechanisms influencing the plasma concentration-time profile, such as activity of metabolizing enzymes and transporters. In cancer treatment, drugs are currently selected regarding molecular properties of the cancer tissue, eg, expressing receptors such as HER2 receptor. Currently diagnostic tests are available allowing to detect somatic cell mutations that can be used to guide drug selection. Unfortunately, tumor heterogeneity and developing resistance by further mutations may limit the success of the therapy determined by molecular diagnostics. The present status can be described that in drug kinetics we know the influencing factors and we understand the mechanisms. However, only in a few cases the genetic background is the main determinant of kinetic variability, and environmental and other factors have an additional important role. Therefore, much more has to be done before we can translate the accumulating knowledge into a benefit for the patient. Only then, we can speak about personalized medicine.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeOstalo - Polemika, diskusija
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 53, br. 4, str. 314-320
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2012.53.314
URN:NBNurn:nbn:hr:105:201122
Datum objave publikacije2012-08
URL dokumentahttp://www.cmj.hr/2012/53/4/22911523.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:36:43