prikaz prve stranice dokumenta Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer
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Scientific paper - Original scientific paper
Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer
International Journal of Colorectal Disease, 22 (2007), 7; 827-831. https://doi.org/10.1007/s00384-006-0200-z
Kovačević, Dujo; Sonicki, Zdenko; Kusić, Zvonko; Bolanča, Ante; Grubišić, Goran; Lukač, Maja; Lukač, Josip

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Kovačević, D., Sonicki, Z., Kusić, Z., Bolanča, A., Grubišić, G., Lukač, M. & Lukač, J. (2007). Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer. International Journal of Colorectal Disease, 22. (7), 827-831. doi: 10.1007/s00384-006-0200-z

Kovačević, Dujo, et al. "Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer." International Journal of Colorectal Disease, vol. 22, no. 7, 2007, pp. 827-831. https://doi.org/10.1007/s00384-006-0200-z

Kovačević, Dujo, Zdenko Sonicki, Zvonko Kusić, Ante Bolanča, Goran Grubišić, Maja Lukač and Josip Lukač. "Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer." International Journal of Colorectal Disease 22, no. 7 (2007): 827-831. https://doi.org/10.1007/s00384-006-0200-z

Kovačević, D., et al. (2007) 'Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer', International Journal of Colorectal Disease, 22(7), pp. 827-831. doi: 10.1007/s00384-006-0200-z

Kovačević D, Sonicki Z, Kusić Z, Bolanča A, Grubišić G, Lukač M, and sur.. Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer. International Journal of Colorectal Disease [Internet]. 2007 July [cited 2024 April 28];22(7):827-831. doi: 10.1007/s00384-006-0200-z

D. Kovačević, et al., "Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer", International Journal of Colorectal Disease, vol. 22, no. 7, pp. 827-831, July 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:632952. [Accessed: 28 April 2024]

Metadata
Title (english)Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer
AuthorDujo Kovačević
AuthorZdenko Sonicki
AuthorZvonko Kusić
AuthorAnte Bolanča
AuthorGoran Grubišić
AuthorMaja Lukač
AuthorJosip Lukač
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND AND AIM: Soluble c-erbB-2 oncoprotein has been proven as a useful marker in the management of breast cancer patients, but its value in diagnostics and follow-up of colorectal cancer patients remains controversial. The aim of this study was to evaluate the usefulness of serum c-erbB-2 monitoring in diagnostics and prediction of disease outcome in rectal cancer patients. - - - - - MATERIALS AND METHODS: Serum samples from 88 patients with rectal adenocarcinoma before surgery and from 41 healthy controls were tested for the presence of c-erbB-2 oncoprotein by ELISA, and the patients were followed up for at least 5 years after the surgery. - - - - - RESULTS: Preoperative serum c-erbB-2 levels were significantly higher in stage IV patients than in healthy controls (P<0.001) and did not show correlation with preoperative CEA levels. Elevated preoperative serum c-erbB-2 levels showed relatively high specificity (88%) and low sensitivity (44%) in the diagnosis of rectal cancer. Elevated preoperative oncoprotein levels were predictive neither for overall survival nor for development of local recurrence/distant metastases. - - - - - CONCLUSION: Although preoperative serum c-erbB-2 levels were significantly higher in rectal cancer patients than in healthy controls, the soluble c-erbB-2 does not seem to be useful in the diagnosis of rectal cancer due to its low sensitivity. Preoperative serum levels of this oncoprotein were predictive neither for overall survival nor for local recurrence/distant metastases in rectal cancer patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleInternational Journal of Colorectal Disease
Numberingvol. 22, no. 7, pp. 827-831
p-ISSN0179-1958
DOIhttps://doi.org/10.1007/s00384-006-0200-z
URN:NBNurn:nbn:hr:105:632952
Publication2007-07
Document URLhttps://doi.org/10.1007/s00384-006-0200-z
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:04:42