prikaz prve stranice dokumenta Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer
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Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer
International Journal of Colorectal Disease, 22 (2007), 7; 827-831. https://doi.org/10.1007/s00384-006-0200-z
Kovačević, Dujo; Sonicki, Zdenko; Kusić, Zvonko; Bolanča, Ante; Grubišić, Goran; Lukač, Maja; Lukač, Josip

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Kovačević, D., Sonicki, Z., Kusić, Z., Bolanča, A., Grubišić, G., Lukač, M. i Lukač, J. (2007). Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer. International Journal of Colorectal Disease, 22. (7), 827-831. doi: 10.1007/s00384-006-0200-z

Kovačević, Dujo, et al. "Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer." International Journal of Colorectal Disease, vol. 22, br. 7, 2007, str. 827-831. https://doi.org/10.1007/s00384-006-0200-z

Kovačević, Dujo, Zdenko Sonicki, Zvonko Kusić, Ante Bolanča, Goran Grubišić, Maja Lukač i Josip Lukač. "Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer." International Journal of Colorectal Disease 22, br. 7 (2007): 827-831. https://doi.org/10.1007/s00384-006-0200-z

Kovačević, D., et al. (2007) 'Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer', International Journal of Colorectal Disease, 22(7), str. 827-831. doi: 10.1007/s00384-006-0200-z

Kovačević D, Sonicki Z, Kusić Z, Bolanča A, Grubišić G, Lukač M, i sur.. Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer. International Journal of Colorectal Disease [Internet]. 07.2007. [pristupljeno 03.05.2024.];22(7):827-831. doi: 10.1007/s00384-006-0200-z

D. Kovačević, et al., "Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer", International Journal of Colorectal Disease, vol. 22, br. 7, str. 827-831, Srpanj 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:632952. [Citirano: 03.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:632952
Podaci o radu
Naslov (engleski)Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer
AutorDujo Kovačević
AutorZdenko Sonicki
AutorZvonko Kusić
AutorAnte Bolanča
AutorGoran Grubišić
AutorMaja Lukač
AutorJosip Lukač
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND AND AIM: Soluble c-erbB-2 oncoprotein has been proven as a useful marker in the management of breast cancer patients, but its value in diagnostics and follow-up of colorectal cancer patients remains controversial. The aim of this study was to evaluate the usefulness of serum c-erbB-2 monitoring in diagnostics and prediction of disease outcome in rectal cancer patients. - - - - - MATERIALS AND METHODS: Serum samples from 88 patients with rectal adenocarcinoma before surgery and from 41 healthy controls were tested for the presence of c-erbB-2 oncoprotein by ELISA, and the patients were followed up for at least 5 years after the surgery. - - - - - RESULTS: Preoperative serum c-erbB-2 levels were significantly higher in stage IV patients than in healthy controls (P<0.001) and did not show correlation with preoperative CEA levels. Elevated preoperative serum c-erbB-2 levels showed relatively high specificity (88%) and low sensitivity (44%) in the diagnosis of rectal cancer. Elevated preoperative oncoprotein levels were predictive neither for overall survival nor for development of local recurrence/distant metastases. - - - - - CONCLUSION: Although preoperative serum c-erbB-2 levels were significantly higher in rectal cancer patients than in healthy controls, the soluble c-erbB-2 does not seem to be useful in the diagnosis of rectal cancer due to its low sensitivity. Preoperative serum levels of this oncoprotein were predictive neither for overall survival nor for local recurrence/distant metastases in rectal cancer patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaInternational Journal of Colorectal Disease
Brojčani podacivol. 22, br. 7, str. 827-831
p-ISSN0179-1958
DOIhttps://doi.org/10.1007/s00384-006-0200-z
URN:NBNurn:nbn:hr:105:632952
Datum objave publikacije2007-07
URL dokumentahttps://doi.org/10.1007/s00384-006-0200-z
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 20:04:42