prikaz prve stranice dokumenta Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis
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Scientific paper - Original scientific paper
Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis
International Orthopaedics, 38 (2014), 1; 183-192. https://doi.org/10.1007/s00264-013-2121-0
Ikić, Marina; Jajić, Zrinka; Lazić, Elvira; Ivčević, Sanja; Grubišić, Frane; Marušić, Ana; Kovačić, Nataša; Grčević, Danka

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Ikić, M., Jajić, Z., Lazić, E., Ivčević, S., Grubišić, F., Marušić, A. ... Grčević, D. (2014). Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis. International Orthopaedics, 38. (1), 183-192. doi: 10.1007/s00264-013-2121-0

Ikić, Marina, et al. "Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis." International Orthopaedics, vol. 38, no. 1, 2014, pp. 183-192. https://doi.org/10.1007/s00264-013-2121-0

Ikić, Marina, Zrinka Jajić, Elvira Lazić, Sanja Ivčević, Frane Grubišić, Ana Marušić, Nataša Kovačić and Danka Grčević. "Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis." International Orthopaedics 38, no. 1 (2014): 183-192. https://doi.org/10.1007/s00264-013-2121-0

Ikić, M., et al. (2014) 'Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis', International Orthopaedics, 38(1), pp. 183-192. doi: 10.1007/s00264-013-2121-0

Ikić M, Jajić Z, Lazić E, Ivčević S, Grubišić F, Marušić A, and sur.. Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis. International Orthopaedics [Internet]. 2014 January [cited 2024 May 05];38(1):183-192. doi: 10.1007/s00264-013-2121-0

M. Ikić, et al., "Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis", International Orthopaedics, vol. 38, no. 1, pp. 183-192, January 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:533262. [Accessed: 05 May 2024]

Metadata
Title (english)Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis
AuthorMarina Ikić
AuthorZrinka Jajić
AuthorElvira Lazić
AuthorSanja Ivčević
AuthorFrane Grubišić
AuthorAna Marušić
AuthorNataša Kovačić
AuthorDanka Grčević
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
PURPOSE: We aimed to assess osteoclastogenic potential of peripheral blood mononuclear cells (PBMC) and synovial fluid-derived mononuclear cells (SFMC) in different forms of arthritis and to correlate it with inflammatory mediators within intra-articular and circulatory compartments. ----- METHODS: Paired PBMC and SFMC samples of patients with rheumatoid arthritis (RA; n = 10) and psoriatic arthritis (PsA; n = 10), and PBMC of healthy controls were cultured to assess osteoclastogenic potential by the number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts (OCs) and expression of OC-related genes (receptor activator of nuclear factor-κΒ (RANK), cFMS, and TRAP). Osteoclastogenesis was correlated with the arthritis-related inflammatory indicators in serum and synovial fluid (SF). ----- RESULTS: Number of OCs differentiated from PBMC was significantly higher in RA and PsA compared with control, with RA having more OCs compared with PsA. There was no difference in SFMC OC number between arthritic patients, but RANK expression in OCs differentiated from SFMC was higher in PsA compared with RA. SF of PsA patients more potently induced OC differentiation from control CD3(-)CD19(-)CD56(-)CD11b(+)CD115(+) PBMC compared with RA, paralleled with higher RANK-ligand expression in PsA SFMC. Positive correlations of OC number with erythrocyte sedimentation rate, serum level of CCL2, and PBMC gene expression of interleukin-18 and Fas-ligand were observed. ----- CONCLUSION: Osteoclastogenic potential is systemically enhanced in patients with RA, paralleled by disordered systemic and local expression of proinflammatory mediators, whereas PsA involves specific deregulation in RANKL/RANK axis. Our study reveals arthritis-specific mediators associated with the form of arthritis, indicating clinical relevance for diagnosis and treatment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleInternational Orthopaedics
Numberingvol. 38, no. 1, pp. 183-192
p-ISSN0341-2695
DOIhttps://doi.org/10.1007/s00264-013-2121-0
URN:NBNurn:nbn:hr:105:533262
Publication2014-01
Document URLhttp://doi.org/10.1007/s00264-013-2121-0
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:02:31