prikaz prve stranice dokumenta Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis
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Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis
International Orthopaedics, 38 (2014), 1; 183-192. https://doi.org/10.1007/s00264-013-2121-0
Ikić, Marina; Jajić, Zrinka; Lazić, Elvira; Ivčević, Sanja; Grubišić, Frane; Marušić, Ana; Kovačić, Nataša; Grčević, Danka

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Ikić, M., Jajić, Z., Lazić, E., Ivčević, S., Grubišić, F., Marušić, A. ... Grčević, D. (2014). Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis. International Orthopaedics, 38. (1), 183-192. doi: 10.1007/s00264-013-2121-0

Ikić, Marina, et al. "Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis." International Orthopaedics, vol. 38, br. 1, 2014, str. 183-192. https://doi.org/10.1007/s00264-013-2121-0

Ikić, Marina, Zrinka Jajić, Elvira Lazić, Sanja Ivčević, Frane Grubišić, Ana Marušić, Nataša Kovačić i Danka Grčević. "Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis." International Orthopaedics 38, br. 1 (2014): 183-192. https://doi.org/10.1007/s00264-013-2121-0

Ikić, M., et al. (2014) 'Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis', International Orthopaedics, 38(1), str. 183-192. doi: 10.1007/s00264-013-2121-0

Ikić M, Jajić Z, Lazić E, Ivčević S, Grubišić F, Marušić A, i sur.. Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis. International Orthopaedics [Internet]. 01.2014. [pristupljeno 26.12.2024.];38(1):183-192. doi: 10.1007/s00264-013-2121-0

M. Ikić, et al., "Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis", International Orthopaedics, vol. 38, br. 1, str. 183-192, Siječanj 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:533262. [Citirano: 26.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:533262
Podaci o radu
Naslov (engleski)Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis
AutorMarina Ikić
AutorZrinka Jajić
AutorElvira Lazić
AutorSanja Ivčević
AutorFrane Grubišić
AutorAna Marušić
AutorNataša Kovačić
AutorDanka Grčević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
PURPOSE: We aimed to assess osteoclastogenic potential of peripheral blood mononuclear cells (PBMC) and synovial fluid-derived mononuclear cells (SFMC) in different forms of arthritis and to correlate it with inflammatory mediators within intra-articular and circulatory compartments. ----- METHODS: Paired PBMC and SFMC samples of patients with rheumatoid arthritis (RA; n = 10) and psoriatic arthritis (PsA; n = 10), and PBMC of healthy controls were cultured to assess osteoclastogenic potential by the number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts (OCs) and expression of OC-related genes (receptor activator of nuclear factor-κΒ (RANK), cFMS, and TRAP). Osteoclastogenesis was correlated with the arthritis-related inflammatory indicators in serum and synovial fluid (SF). ----- RESULTS: Number of OCs differentiated from PBMC was significantly higher in RA and PsA compared with control, with RA having more OCs compared with PsA. There was no difference in SFMC OC number between arthritic patients, but RANK expression in OCs differentiated from SFMC was higher in PsA compared with RA. SF of PsA patients more potently induced OC differentiation from control CD3(-)CD19(-)CD56(-)CD11b(+)CD115(+) PBMC compared with RA, paralleled with higher RANK-ligand expression in PsA SFMC. Positive correlations of OC number with erythrocyte sedimentation rate, serum level of CCL2, and PBMC gene expression of interleukin-18 and Fas-ligand were observed. ----- CONCLUSION: Osteoclastogenic potential is systemically enhanced in patients with RA, paralleled by disordered systemic and local expression of proinflammatory mediators, whereas PsA involves specific deregulation in RANKL/RANK axis. Our study reveals arthritis-specific mediators associated with the form of arthritis, indicating clinical relevance for diagnosis and treatment.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaInternational Orthopaedics
Brojčani podacivol. 38, br. 1, str. 183-192
p-ISSN0341-2695
DOIhttps://doi.org/10.1007/s00264-013-2121-0
URN:NBNurn:nbn:hr:105:533262
Datum objave publikacije2014-01
URL dokumentahttp://doi.org/10.1007/s00264-013-2121-0
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:02:31