prikaz prve stranice dokumenta Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes
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Scientific paper - Original scientific paper
Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes
Inflammation, 35 (2012), 5; 1618-1631. https://doi.org/10.1007/s10753-012-9477-y
Cvija, Hrvoje; Kovačić, Nataša; Katavić, Vedran; Ivčević, Sanja; Aguila, Hector Leonardo; Marušić, Ana; Grčević, Danka

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Cvija, H., Kovačić, N., Katavić, V., Ivčević, S., Aguila, H. L., Marušić, A. & Grčević, D. (2012). Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes. Inflammation, 35. (5), 1618-1631. doi: 10.1007/s10753-012-9477-y

Cvija, Hrvoje, et al. "Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes." Inflammation, vol. 35, no. 5, 2012, pp. 1618-1631. https://doi.org/10.1007/s10753-012-9477-y

Cvija, Hrvoje, Nataša Kovačić, Vedran Katavić, Sanja Ivčević, Hector Leonardo Aguila, Ana Marušić and Danka Grčević. "Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes." Inflammation 35, no. 5 (2012): 1618-1631. https://doi.org/10.1007/s10753-012-9477-y

Cvija, H., et al. (2012) 'Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes', Inflammation, 35(5), pp. 1618-1631. doi: 10.1007/s10753-012-9477-y

Cvija H, Kovačić N, Katavić V, Ivčević S, Aguila HL, Marušić A, and sur.. Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes. Inflammation [Internet]. 2012 October [cited 2024 December 27];35(5):1618-1631. doi: 10.1007/s10753-012-9477-y

H. Cvija, et al., "Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes", Inflammation, vol. 35, no. 5, pp. 1618-1631, October 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:353713. [Accessed: 27 December 2024]

Metadata
Title (english)Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes
AuthorHrvoje Cvija
AuthorNataša Kovačić
AuthorVedran Katavić
AuthorSanja Ivčević
AuthorHector Leonardo Aguila
AuthorAna Marušić
AuthorDanka Grčević
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
In our study, we explored the bidirectional communication via soluble factors between bone cells and endotoxin-stimulated splenic lymphocytes in an in vitro coculture model that mimics the inflammatory environment. Both the ability of lymphocytes to affect differentiation and immune properties of bone cells, osteoblasts (OBL) and osteoclasts (OCL), and of bone cells to modulate cytokine and activation profile of endotoxin-stimulated lymphocytes were tested. LPS-pulsed lymphocytes enhanced OCL but inhibited OBL differentiation and increased the RANKL/OPG ratio, and, at the same time, upregulated chemotactic properties of bone cells, specifically CCL2, CCL5, and CXCL10 in OCL and CCL5 and CXCL13 in OBL. In parallel, bone cells had immunosuppressive effects by downregulating the lymphocyte expression of interleukin (IL)-1, IL-6, TNF-α and co-stimulatory molecules. OCL stimulated the production of osteoclastogenic cytokine RANKL in T lymphocytes. The anti-inflammatory effect, especially of OBL, suggests a possible compensatory mechanism to limit the inflammatory reaction during infection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleInflammation
Numberingvol. 35, no. 5, pp. 1618-1631
p-ISSN0360-3997
DOIhttps://doi.org/10.1007/s10753-012-9477-y
URN:NBNurn:nbn:hr:105:353713
Publication2012-10
Document URLhttps://doi.org/10.1007/s10753-012-9477-y
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:10:02