prikaz prve stranice dokumenta Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes
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Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes
Inflammation, 35 (2012), 5; 1618-1631. https://doi.org/10.1007/s10753-012-9477-y
Cvija, Hrvoje; Kovačić, Nataša; Katavić, Vedran; Ivčević, Sanja; Aguila, Hector Leonardo; Marušić, Ana; Grčević, Danka

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Cvija, H., Kovačić, N., Katavić, V., Ivčević, S., Aguila, H. L., Marušić, A. i Grčević, D. (2012). Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes. Inflammation, 35. (5), 1618-1631. doi: 10.1007/s10753-012-9477-y

Cvija, Hrvoje, et al. "Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes." Inflammation, vol. 35, br. 5, 2012, str. 1618-1631. https://doi.org/10.1007/s10753-012-9477-y

Cvija, Hrvoje, Nataša Kovačić, Vedran Katavić, Sanja Ivčević, Hector Leonardo Aguila, Ana Marušić i Danka Grčević. "Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes." Inflammation 35, br. 5 (2012): 1618-1631. https://doi.org/10.1007/s10753-012-9477-y

Cvija, H., et al. (2012) 'Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes', Inflammation, 35(5), str. 1618-1631. doi: 10.1007/s10753-012-9477-y

Cvija H, Kovačić N, Katavić V, Ivčević S, Aguila HL, Marušić A, i sur.. Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes. Inflammation [Internet]. 10.2012. [pristupljeno 27.12.2024.];35(5):1618-1631. doi: 10.1007/s10753-012-9477-y

H. Cvija, et al., "Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes", Inflammation, vol. 35, br. 5, str. 1618-1631, Listopad 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:353713. [Citirano: 27.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:353713
Podaci o radu
Naslov (engleski)Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes
AutorHrvoje Cvija
AutorNataša Kovačić
AutorVedran Katavić
AutorSanja Ivčević
AutorHector Leonardo Aguila
AutorAna Marušić
AutorDanka Grčević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
In our study, we explored the bidirectional communication via soluble factors between bone cells and endotoxin-stimulated splenic lymphocytes in an in vitro coculture model that mimics the inflammatory environment. Both the ability of lymphocytes to affect differentiation and immune properties of bone cells, osteoblasts (OBL) and osteoclasts (OCL), and of bone cells to modulate cytokine and activation profile of endotoxin-stimulated lymphocytes were tested. LPS-pulsed lymphocytes enhanced OCL but inhibited OBL differentiation and increased the RANKL/OPG ratio, and, at the same time, upregulated chemotactic properties of bone cells, specifically CCL2, CCL5, and CXCL10 in OCL and CCL5 and CXCL13 in OBL. In parallel, bone cells had immunosuppressive effects by downregulating the lymphocyte expression of interleukin (IL)-1, IL-6, TNF-α and co-stimulatory molecules. OCL stimulated the production of osteoclastogenic cytokine RANKL in T lymphocytes. The anti-inflammatory effect, especially of OBL, suggests a possible compensatory mechanism to limit the inflammatory reaction during infection.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaInflammation
Brojčani podacivol. 35, br. 5, str. 1618-1631
p-ISSN0360-3997
DOIhttps://doi.org/10.1007/s10753-012-9477-y
URN:NBNurn:nbn:hr:105:353713
Datum objave publikacije2012-10
URL dokumentahttps://doi.org/10.1007/s10753-012-9477-y
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:10:02