prikaz prve stranice dokumenta Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma
  Download
PDF 610.31 KB
Scientific paper - Original scientific paper
Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma
Journal of Translational Medicine, 11 (2013); 123. https://doi.org/10.1186/1479-5876-11-123
Hudolin, Tvrtko; Kaštelan, Željko; Ilić, Ivana; Levarda-Hudolin, Katarina; Bašić-Jukić, Nikolina; Rieken, Malte; Spagnoli, Giulio C.; Juretić, Antonio; Mengus, Chantal

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Hudolin, T., Kaštelan, Ž., Ilić, I., Levarda Hudolin, K., Bašić Jukić, N., Rieken, M. ... Mengus, C. (2013). Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma. Journal of Translational Medicine, 11., 123. doi: 10.1186/1479-5876-11-123

Hudolin, Tvrtko, et al. "Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma." Journal of Translational Medicine, vol. 11, 2013, p. 123. https://doi.org/10.1186/1479-5876-11-123

Hudolin, Tvrtko, Željko Kaštelan, Ivana Ilić, Katarina Levarda Hudolin, Nikolina Bašić Jukić, Malte Rieken, Giulio C. Spagnoli, Antonio Juretić and Chantal Mengus. "Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma." Journal of Translational Medicine 11 (2013): 123. https://doi.org/10.1186/1479-5876-11-123

Hudolin, T., et al. (2013) 'Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma', Journal of Translational Medicine, 11, p. 123. doi: 10.1186/1479-5876-11-123

Hudolin T, Kaštelan Ž, Ilić I, Levarda Hudolin K, Bašić Jukić N, Rieken M, and sur.. Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma. Journal of Translational Medicine [Internet]. 2013 May 16 [cited 2024 November 08];11:123. doi: 10.1186/1479-5876-11-123

T. Hudolin, et al., "Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma", Journal of Translational Medicine, vol. 11, p. 123, May 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:632408. [Accessed: 08 November 2024]

Metadata
Title (english)Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma
AuthorTvrtko Hudolin
AuthorŽeljko Kaštelan
AuthorIvana Ilić
AuthorKatarina Levarda-Hudolin
AuthorNikolina Bašić-Jukić
AuthorMalte Rieken
AuthorGiulio C. Spagnoli
AuthorAntonio Juretić
AuthorChantal Mengus
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Primary testicular lymphoma (PTL) is a rare and lethal disease. The most common histological subtype is diffuse large B-cell lymphoma (DLBCL). Standard treatments are frequently ineffective. Thus, the development of novel forms of therapy is urgently required. Specific immunotherapy generating immune responses directed against antigen predominantly expressed by cancer cells such as cancer-testis antigens (CTA) may provide a valid alternative treatment for patients bearing PTL, alone or in combination with current therapies. ----- METHODS: Three monoclonal antibodies (mAbs), 77B recognizing MAGE-A1, 57B recognizing an epitope shared by multiple MAGE-A CTA (multi-MAGE-A specific) and D8.38 recognizing NY-ESO-1/LAGE-1 were used for immunohistochemical staining of 27 PTL, including 24 DLBCL. ----- RESULTS: Expression of MAGE-A1 was infrequently detectable in DLBCL specimens (12.50%), whereas multi-MAGE-A and NY-ESO-1/LAGE-1 specific reagents stained the cytoplasms of tumor cells in DLBCL specimens with higher frequencies (54.17% and 37.50%, respectively) with different expression levels. ----- CONCLUSIONS: These results suggest that MAGE-A and NY-ESO-1/LAGE-1, possibly in combination with other CTA, might be used as targets for specific immunotherapy in DLBCL.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Translational Medicine
Numberingvol. 11, p. 123
p-ISSN1479-5876
DOIhttps://doi.org/10.1186/1479-5876-11-123
URN:NBNurn:nbn:hr:105:632408
Publication2013-05-16
Document URLhttp://doi.org/10.1186/1479-5876-11-123
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:12:02