prikaz prve stranice dokumenta Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma
  Preuzmi
PDF 610.31 KB
Znanstveni rad - Izvorni znanstveni rad
Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma
Journal of Translational Medicine, 11 (2013); 123. https://doi.org/10.1186/1479-5876-11-123
Hudolin, Tvrtko; Kaštelan, Željko; Ilić, Ivana; Levarda-Hudolin, Katarina; Bašić-Jukić, Nikolina; Rieken, Malte; Spagnoli, Giulio C.; Juretić, Antonio; Mengus, Chantal

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Hudolin, T., Kaštelan, Ž., Ilić, I., Levarda Hudolin, K., Bašić Jukić, N., Rieken, M. ... Mengus, C. (2013). Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma. Journal of Translational Medicine, 11., 123. doi: 10.1186/1479-5876-11-123

Hudolin, Tvrtko, et al. "Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma." Journal of Translational Medicine, vol. 11, 2013, str. 123. https://doi.org/10.1186/1479-5876-11-123

Hudolin, Tvrtko, Željko Kaštelan, Ivana Ilić, Katarina Levarda Hudolin, Nikolina Bašić Jukić, Malte Rieken, Giulio C. Spagnoli, Antonio Juretić i Chantal Mengus. "Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma." Journal of Translational Medicine 11 (2013): 123. https://doi.org/10.1186/1479-5876-11-123

Hudolin, T., et al. (2013) 'Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma', Journal of Translational Medicine, 11, str. 123. doi: 10.1186/1479-5876-11-123

Hudolin T, Kaštelan Ž, Ilić I, Levarda Hudolin K, Bašić Jukić N, Rieken M, i sur.. Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma. Journal of Translational Medicine [Internet]. 16.05.2013. [pristupljeno 09.05.2024.];11:123. doi: 10.1186/1479-5876-11-123

T. Hudolin, et al., "Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma", Journal of Translational Medicine, vol. 11, str. 123, Svibanj 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:632408. [Citirano: 09.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:632408
Podaci o radu
Naslov (engleski)Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma
AutorTvrtko Hudolin
AutorŽeljko Kaštelan
AutorIvana Ilić
AutorKatarina Levarda-Hudolin
AutorNikolina Bašić-Jukić
AutorMalte Rieken
AutorGiulio C. Spagnoli
AutorAntonio Juretić
AutorChantal Mengus
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Primary testicular lymphoma (PTL) is a rare and lethal disease. The most common histological subtype is diffuse large B-cell lymphoma (DLBCL). Standard treatments are frequently ineffective. Thus, the development of novel forms of therapy is urgently required. Specific immunotherapy generating immune responses directed against antigen predominantly expressed by cancer cells such as cancer-testis antigens (CTA) may provide a valid alternative treatment for patients bearing PTL, alone or in combination with current therapies. ----- METHODS: Three monoclonal antibodies (mAbs), 77B recognizing MAGE-A1, 57B recognizing an epitope shared by multiple MAGE-A CTA (multi-MAGE-A specific) and D8.38 recognizing NY-ESO-1/LAGE-1 were used for immunohistochemical staining of 27 PTL, including 24 DLBCL. ----- RESULTS: Expression of MAGE-A1 was infrequently detectable in DLBCL specimens (12.50%), whereas multi-MAGE-A and NY-ESO-1/LAGE-1 specific reagents stained the cytoplasms of tumor cells in DLBCL specimens with higher frequencies (54.17% and 37.50%, respectively) with different expression levels. ----- CONCLUSIONS: These results suggest that MAGE-A and NY-ESO-1/LAGE-1, possibly in combination with other CTA, might be used as targets for specific immunotherapy in DLBCL.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Translational Medicine
Brojčani podacivol. 11, str. 123
p-ISSN1479-5876
DOIhttps://doi.org/10.1186/1479-5876-11-123
URN:NBNurn:nbn:hr:105:632408
Datum objave publikacije2013-05-16
URL dokumentahttp://doi.org/10.1186/1479-5876-11-123
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:12:02