prikaz prve stranice dokumenta Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)
  Download
PDF 504.81 KB
Scientific paper - Original scientific paper
Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)
Journal of Thrombosis and Thrombolysis, 39 (2015), 4; 522-531. https://doi.org/10.1007/s11239-014-1127-9
Petričević, Mate; Kopjar, Tomislav; Gašparović, Hrvoje; Miličić, Davor; Svetina, Lucija; Zdilar, Boris; Boban, Marko; Zrno Mihaljević, Martina; Biočina, Bojan

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Petričević, M., Kopjar, T., Gašparović, H., Miličić, D., Svetina, L., Zdilar, B. ... Biočina, B. (2015). Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639). Journal of Thrombosis and Thrombolysis, 39. (4), 522-531. doi: 10.1007/s11239-014-1127-9

Petričević, Mate, et al. "Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)." Journal of Thrombosis and Thrombolysis, vol. 39, no. 4, 2015, pp. 522-531. https://doi.org/10.1007/s11239-014-1127-9

Petričević, Mate, Tomislav Kopjar, Hrvoje Gašparović, Davor Miličić, Lucija Svetina, Boris Zdilar, Marko Boban, Martina Zrno Mihaljević and Bojan Biočina. "Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)." Journal of Thrombosis and Thrombolysis 39, no. 4 (2015): 522-531. https://doi.org/10.1007/s11239-014-1127-9

Petričević, M., et al. (2015) 'Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)', Journal of Thrombosis and Thrombolysis, 39(4), pp. 522-531. doi: 10.1007/s11239-014-1127-9

Petričević M, Kopjar T, Gašparović H, Miličić D, Svetina L, Zdilar B, and sur.. Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639). Journal of Thrombosis and Thrombolysis [Internet]. 2015 May [cited 2024 May 01];39(4):522-531. doi: 10.1007/s11239-014-1127-9

M. Petričević, et al., "Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)", Journal of Thrombosis and Thrombolysis, vol. 39, no. 4, pp. 522-531, May 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:029573. [Accessed: 01 May 2024]

Metadata
Title (english)Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)
AuthorMate Petričević
AuthorTomislav Kopjar
AuthorHrvoje Gašparović
AuthorDavor Miličić
AuthorLucija Svetina
AuthorBoris Zdilar
AuthorMarko Boban
AuthorMartina Zrno Mihaljević
AuthorBojan Biočina
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Individual variability in the response to aspirin, has been established by various platelet function assays, however, the clinical relevance of aspirin resistance (AR) in patients undergoing coronary artery bypass grafting (CABG) has to be evaluated. Our working group conducted a randomized controlled trial (NCT01159639) with the aim to assess impact of dual antiplatelet therapy (APT) on outcomes among patients with AR following CABG. Patients that were aspirin resistant on fourth postoperative day (POD 4) were randomly assigned to receive either dual APT with clopidogrel (75 mg) plus aspirin (300 mg)-intervention arm or monotherapy with aspirin (300 mg)-control arm. This exploratory analysis compares clinical outcomes between aspirin resistant patients allocated to control arm and patients that have had adequate platelet inhibitory response to aspirin at POD 4. Both groups were treated with 300 mg of aspirin per day following surgery. We sought to evaluate the impact of early postoperative AR on outcomes among patients following CABG. Exploratory analysis included a total number of 325 patients. Of those, 215 patients with adequate response to aspirin and 110 patients with AR allocated to aspirin monotherapy following randomization protocol. The primary efficacy end point (MACCEs-major adverse cardiac and cardiovascular events) occurred in 10 and 6 % of patients with AR and with adequate aspirin response, respectively (p = 0.27). Non-significant differences were observed in bleeding events occurrence. Subgroup analysis of the primary end point revealed that aspirin resistant patients with BMI > 30 kg/m(2) tend to have a higher occurrence of MACCEs 18 versus 5 % (relative risk 0.44 [95 % CI 0.16-1.16]; p = 0.05). This exploratory analysis did not reveal significant impact of aspirin resistance on outcomes among patients undergoing CABG. Further, sufficiently powered studies are needed in order to evaluate clinical relevance of AR in patients undergoing CABG.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Thrombosis and Thrombolysis
Numberingvol. 39, no. 4, pp. 522-531
p-ISSN0929-5305
DOIhttps://doi.org/10.1007/s11239-014-1127-9
URN:NBNurn:nbn:hr:105:029573
Publication2015-05
Document URLhttps://doi.org/10.1007/s11239-014-1127-9
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:13:09