prikaz prve stranice dokumenta Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)
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Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)
Journal of Thrombosis and Thrombolysis, 39 (2015), 4; 522-531. https://doi.org/10.1007/s11239-014-1127-9
Petričević, Mate; Kopjar, Tomislav; Gašparović, Hrvoje; Miličić, Davor; Svetina, Lucija; Zdilar, Boris; Boban, Marko; Zrno Mihaljević, Martina; Biočina, Bojan

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Petričević, M., Kopjar, T., Gašparović, H., Miličić, D., Svetina, L., Zdilar, B. ... Biočina, B. (2015). Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639). Journal of Thrombosis and Thrombolysis, 39. (4), 522-531. doi: 10.1007/s11239-014-1127-9

Petričević, Mate, et al. "Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)." Journal of Thrombosis and Thrombolysis, vol. 39, br. 4, 2015, str. 522-531. https://doi.org/10.1007/s11239-014-1127-9

Petričević, Mate, Tomislav Kopjar, Hrvoje Gašparović, Davor Miličić, Lucija Svetina, Boris Zdilar, Marko Boban, Martina Zrno Mihaljević i Bojan Biočina. "Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)." Journal of Thrombosis and Thrombolysis 39, br. 4 (2015): 522-531. https://doi.org/10.1007/s11239-014-1127-9

Petričević, M., et al. (2015) 'Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)', Journal of Thrombosis and Thrombolysis, 39(4), str. 522-531. doi: 10.1007/s11239-014-1127-9

Petričević M, Kopjar T, Gašparović H, Miličić D, Svetina L, Zdilar B, i sur.. Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639). Journal of Thrombosis and Thrombolysis [Internet]. 05.2015. [pristupljeno 26.11.2024.];39(4):522-531. doi: 10.1007/s11239-014-1127-9

M. Petričević, et al., "Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)", Journal of Thrombosis and Thrombolysis, vol. 39, br. 4, str. 522-531, Svibanj 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:029573. [Citirano: 26.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:029573
Podaci o radu
Naslov (engleski)Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639)
AutorMate Petričević
AutorTomislav Kopjar
AutorHrvoje Gašparović
AutorDavor Miličić
AutorLucija Svetina
AutorBoris Zdilar
AutorMarko Boban
AutorMartina Zrno Mihaljević
AutorBojan Biočina
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Individual variability in the response to aspirin, has been established by various platelet function assays, however, the clinical relevance of aspirin resistance (AR) in patients undergoing coronary artery bypass grafting (CABG) has to be evaluated. Our working group conducted a randomized controlled trial (NCT01159639) with the aim to assess impact of dual antiplatelet therapy (APT) on outcomes among patients with AR following CABG. Patients that were aspirin resistant on fourth postoperative day (POD 4) were randomly assigned to receive either dual APT with clopidogrel (75 mg) plus aspirin (300 mg)-intervention arm or monotherapy with aspirin (300 mg)-control arm. This exploratory analysis compares clinical outcomes between aspirin resistant patients allocated to control arm and patients that have had adequate platelet inhibitory response to aspirin at POD 4. Both groups were treated with 300 mg of aspirin per day following surgery. We sought to evaluate the impact of early postoperative AR on outcomes among patients following CABG. Exploratory analysis included a total number of 325 patients. Of those, 215 patients with adequate response to aspirin and 110 patients with AR allocated to aspirin monotherapy following randomization protocol. The primary efficacy end point (MACCEs-major adverse cardiac and cardiovascular events) occurred in 10 and 6 % of patients with AR and with adequate aspirin response, respectively (p = 0.27). Non-significant differences were observed in bleeding events occurrence. Subgroup analysis of the primary end point revealed that aspirin resistant patients with BMI > 30 kg/m(2) tend to have a higher occurrence of MACCEs 18 versus 5 % (relative risk 0.44 [95 % CI 0.16-1.16]; p = 0.05). This exploratory analysis did not reveal significant impact of aspirin resistance on outcomes among patients undergoing CABG. Further, sufficiently powered studies are needed in order to evaluate clinical relevance of AR in patients undergoing CABG.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Thrombosis and Thrombolysis
Brojčani podacivol. 39, br. 4, str. 522-531
p-ISSN0929-5305
DOIhttps://doi.org/10.1007/s11239-014-1127-9
URN:NBNurn:nbn:hr:105:029573
Datum objave publikacije2015-05
URL dokumentahttps://doi.org/10.1007/s11239-014-1127-9
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:13:09