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Scientific paper - Original scientific paper
STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons
Molecular and Cellular Neuroscience, 67 (2015); 104-115. https://doi.org/10.1016/j.mcn.2015.06.009
Kapuralin, Katarina; Ćurlin, Marija; Mitrečić, Dinko; Kosi, Nina; Schwarzer, Christoph; Glavan, Gordana; Gajović, Srećko

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Kapuralin, K., Ćurlin, M., Mitrečić, D., Kosi, N., Schwarzer, C., Glavan, G. & Gajović, S. (2015). STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons. Molecular and Cellular Neuroscience, 67., 104-115. doi: 10.1016/j.mcn.2015.06.009

Kapuralin, Katarina, et al. "STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons." Molecular and Cellular Neuroscience, vol. 67, 2015, pp. 104-115. https://doi.org/10.1016/j.mcn.2015.06.009

Kapuralin, Katarina, Marija Ćurlin, Dinko Mitrečić, Nina Kosi, Christoph Schwarzer, Gordana Glavan and Srećko Gajović. "STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons." Molecular and Cellular Neuroscience 67 (2015): 104-115. https://doi.org/10.1016/j.mcn.2015.06.009

Kapuralin, K., et al. (2015) 'STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons', Molecular and Cellular Neuroscience, 67, pp. 104-115. doi: 10.1016/j.mcn.2015.06.009

Kapuralin K, Ćurlin M, Mitrečić D, Kosi N, Schwarzer C, Glavan G, and sur.. STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons. Molecular and Cellular Neuroscience [Internet]. 2015 July [cited 2024 May 14];67:104-115. doi: 10.1016/j.mcn.2015.06.009

K. Kapuralin, et al., "STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons", Molecular and Cellular Neuroscience, vol. 67, pp. 104-115, July 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:983995. [Accessed: 14 May 2024]

Metadata
Title (english)STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons
AuthorKatarina Kapuralin
AuthorMarija Ćurlin
AuthorDinko Mitrečić
AuthorNina Kosi
AuthorChristoph Schwarzer
AuthorGordana Glavan
AuthorSrećko Gajović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
STAM2 (signal transducing adaptor molecule 2), a subunit of the ESCRT-0 complex, is an endosomal protein acting as a regulator of receptor signaling and trafficking. To analyze STAM2 in the nervous system, its gene expression and protein localization in the mouse brain were identified using three methods: mRNA in situ hybridization, immunohistochemistry, and via lacZ reporter in frame with Stam2 gene using the gene trap mouse line Stam2(Gt1Gaj). STAM2 intracellular localization was analyzed by subcellular fractionation and co-immunofluorescence using confocal microscopy. Stam2 was strongly expressed in the cerebral and cerebellar cortex, hippocampal formation, olfactory bulb, and medial habenula. The majority of STAM2-positive cells co-stained with the neuronal markers. In neurons STAM2 was found in the early endosomes and also in the nucleus. The other members of the ESCRT-0 complex co-localized with STAM2 in the cytoplasm, but they were not present in the nucleus. The newly identified neuron-specific nuclear localization of STAM2, together with its high expression in the brain indicated that STAM2 might have a specific function in the mouse nervous system.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMolecular and Cellular Neuroscience
Numberingvol. 67, pp. 104-115
p-ISSN1044-7431
DOIhttps://doi.org/10.1016/j.mcn.2015.06.009
URN:NBNurn:nbn:hr:105:983995
Publication2015-07
Document URLhttps://doi.org/10.1016/j.mcn.2015.06.009
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:16:58