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STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons
Molecular and Cellular Neuroscience, 67 (2015); 104-115. https://doi.org/10.1016/j.mcn.2015.06.009
Kapuralin, Katarina; Ćurlin, Marija; Mitrečić, Dinko; Kosi, Nina; Schwarzer, Christoph; Glavan, Gordana; Gajović, Srećko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Kapuralin, K., Ćurlin, M., Mitrečić, D., Kosi, N., Schwarzer, C., Glavan, G. i Gajović, S. (2015). STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons. Molecular and Cellular Neuroscience, 67., 104-115. doi: 10.1016/j.mcn.2015.06.009

Kapuralin, Katarina, et al. "STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons." Molecular and Cellular Neuroscience, vol. 67, 2015, str. 104-115. https://doi.org/10.1016/j.mcn.2015.06.009

Kapuralin, Katarina, Marija Ćurlin, Dinko Mitrečić, Nina Kosi, Christoph Schwarzer, Gordana Glavan i Srećko Gajović. "STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons." Molecular and Cellular Neuroscience 67 (2015): 104-115. https://doi.org/10.1016/j.mcn.2015.06.009

Kapuralin, K., et al. (2015) 'STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons', Molecular and Cellular Neuroscience, 67, str. 104-115. doi: 10.1016/j.mcn.2015.06.009

Kapuralin K, Ćurlin M, Mitrečić D, Kosi N, Schwarzer C, Glavan G, i sur.. STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons. Molecular and Cellular Neuroscience [Internet]. 07.2015. [pristupljeno 28.04.2024.];67:104-115. doi: 10.1016/j.mcn.2015.06.009

K. Kapuralin, et al., "STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons", Molecular and Cellular Neuroscience, vol. 67, str. 104-115, Srpanj 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:983995. [Citirano: 28.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:983995
Podaci o radu
Naslov (engleski)STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons
AutorKatarina Kapuralin
AutorMarija Ćurlin
AutorDinko Mitrečić
AutorNina Kosi
AutorChristoph Schwarzer
AutorGordana Glavan
AutorSrećko Gajović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
STAM2 (signal transducing adaptor molecule 2), a subunit of the ESCRT-0 complex, is an endosomal protein acting as a regulator of receptor signaling and trafficking. To analyze STAM2 in the nervous system, its gene expression and protein localization in the mouse brain were identified using three methods: mRNA in situ hybridization, immunohistochemistry, and via lacZ reporter in frame with Stam2 gene using the gene trap mouse line Stam2(Gt1Gaj). STAM2 intracellular localization was analyzed by subcellular fractionation and co-immunofluorescence using confocal microscopy. Stam2 was strongly expressed in the cerebral and cerebellar cortex, hippocampal formation, olfactory bulb, and medial habenula. The majority of STAM2-positive cells co-stained with the neuronal markers. In neurons STAM2 was found in the early endosomes and also in the nucleus. The other members of the ESCRT-0 complex co-localized with STAM2 in the cytoplasm, but they were not present in the nucleus. The newly identified neuron-specific nuclear localization of STAM2, together with its high expression in the brain indicated that STAM2 might have a specific function in the mouse nervous system.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecular and Cellular Neuroscience
Brojčani podacivol. 67, str. 104-115
p-ISSN1044-7431
DOIhttps://doi.org/10.1016/j.mcn.2015.06.009
URN:NBNurn:nbn:hr:105:983995
Datum objave publikacije2015-07
URL dokumentahttps://doi.org/10.1016/j.mcn.2015.06.009
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:16:58