prikaz prve stranice dokumenta Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study
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Scientific paper - Original scientific paper
Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study
BMJ Open, 4 (2014), 7; e005005. https://doi.org/10.1136/bmjopen-2014-005005
Mihovilović, Karlo; Maksimović, Bojana; Kocman, Branislav; Guštin, Denis; Vidas, Željko; Bulimbašić, Stela; Galešić Ljubanović, Danica; Sabljar Matovinović, Mirjana; Knotek, Mladen

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Mihovilović, K., Maksimović, B., Kocman, B., Guštin, D., Vidas, Ž., Bulimbašić, S. ... Knotek, M. (2014). Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study. BMJ Open, 4. (7). doi: 10.1136/bmjopen-2014-005005

Mihovilović, Karlo, et al. "Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study." BMJ Open, vol. 4, no. 7, 2014. https://doi.org/10.1136/bmjopen-2014-005005

Mihovilović, Karlo, Bojana Maksimović, Branislav Kocman, Denis Guštin, Željko Vidas, Stela Bulimbašić, Danica Galešić Ljubanović, Mirjana Sabljar Matovinović and Mladen Knotek. "Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study." BMJ Open 4, no. 7 (2014). https://doi.org/10.1136/bmjopen-2014-005005

Mihovilović, K., et al. (2014) 'Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study', BMJ Open, 4(7). doi: 10.1136/bmjopen-2014-005005

Mihovilović K, Maksimović B, Kocman B, Guštin D, Vidas Ž, Bulimbašić S, and sur.. Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study. BMJ Open [Internet]. 2014 July 03 [cited 2024 November 22];4(7). doi: 10.1136/bmjopen-2014-005005

K. Mihovilović, et al., "Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study", BMJ Open, vol. 4, no. 7, July 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:820558. [Accessed: 22 November 2024]

Metadata
Title (english)Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study
AuthorKarlo Mihovilović
AuthorBojana Maksimović
AuthorBranislav Kocman
AuthorDenis Guštin
AuthorŽeljko Vidas
AuthorStela Bulimbašić
AuthorDanica Galešić Ljubanović
AuthorMirjana Sabljar Matovinović
AuthorMladen Knotek
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVES: Chronic transplant dysfunction after kidney transplantation is a major reason of kidney graft loss and is caused by immunological and non-immunological factors. There is evidence that mycophenolate mofetil (MMF) may exert a positive effect on renal damage in addition to immunosuppression, by its direct antifibrotic properties. The aim of our study was to retrospectively investigate the role of MMF doses on progression of chronic allograft dysfunction and fibrosis and tubular atrophy (IF/TA). ----- SETTING: Retrospective, cohort study. ----- PARTICIPANTS: Patients with kidney transplant in a tertiary care institution. This is a retrospective cohort study that included 79 patients with kidney and kidney-pancreas transplantation. Immunosuppression consisted of anti-interleukin 2 antibody induction, MMF, a calcineurin inhibitor±steroids. ----- PRIMARY OUTCOME MEASURES: An association of average MMF doses over 1 year post-transplant with progression of interstitial fibrosis (Δci), tubular atrophy (Δct) and estimated-creatinine clearance (eCrcl) at 1 year post-transplant was evaluated using univariate and multivariate analyses. ----- RESULTS: A higher average MMF dose was significantly independently associated with better eCrcl at 1 year post-transplant (b=0.21±0.1, p=0.04). In multiple regression analysis lower Δci (b=-0.2±0.09, p=0.05) and Δct (b=-0.29±0.1, p=0.02) were independently associated with a greater average MMF dose. There was no correlation between average MMF doses and incidence of acute rejection (p=0.68). ----- CONCLUSIONS: A higher average MMF dose over 1 year is associated with better renal function and slower progression of IF/TA, at least partly independent of its immunosuppressive effects.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBMJ Open
Numberingvol. 4, no. 7, e005005
p-ISSN2044-6055
DOIhttps://doi.org/10.1136/bmjopen-2014-005005
URN:NBNurn:nbn:hr:105:820558
Publication2014-07-03
Document URLhttps://doi.org/10.1136/bmjopen-2014-005005
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:29:15