prikaz prve stranice dokumenta Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study
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Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study
BMJ Open, 4 (2014), 7; e005005. https://doi.org/10.1136/bmjopen-2014-005005
Mihovilović, Karlo; Maksimović, Bojana; Kocman, Branislav; Guštin, Denis; Vidas, Željko; Bulimbašić, Stela; Galešić Ljubanović, Danica; Sabljar Matovinović, Mirjana; Knotek, Mladen

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Mihovilović, K., Maksimović, B., Kocman, B., Guštin, D., Vidas, Ž., Bulimbašić, S. ... Knotek, M. (2014). Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study. BMJ Open, 4. (7). doi: 10.1136/bmjopen-2014-005005

Mihovilović, Karlo, et al. "Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study." BMJ Open, vol. 4, br. 7, 2014. https://doi.org/10.1136/bmjopen-2014-005005

Mihovilović, Karlo, Bojana Maksimović, Branislav Kocman, Denis Guštin, Željko Vidas, Stela Bulimbašić, Danica Galešić Ljubanović, Mirjana Sabljar Matovinović i Mladen Knotek. "Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study." BMJ Open 4, br. 7 (2014). https://doi.org/10.1136/bmjopen-2014-005005

Mihovilović, K., et al. (2014) 'Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study', BMJ Open, 4(7). doi: 10.1136/bmjopen-2014-005005

Mihovilović K, Maksimović B, Kocman B, Guštin D, Vidas Ž, Bulimbašić S, i sur.. Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study. BMJ Open [Internet]. 03.07.2014. [pristupljeno 25.12.2024.];4(7). doi: 10.1136/bmjopen-2014-005005

K. Mihovilović, et al., "Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study", BMJ Open, vol. 4, br. 7, Srpanj 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:820558. [Citirano: 25.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:820558
Podaci o radu
Naslov (engleski)Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study
AutorKarlo Mihovilović
AutorBojana Maksimović
AutorBranislav Kocman
AutorDenis Guštin
AutorŽeljko Vidas
AutorStela Bulimbašić
AutorDanica Galešić Ljubanović
AutorMirjana Sabljar Matovinović
AutorMladen Knotek
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
OBJECTIVES: Chronic transplant dysfunction after kidney transplantation is a major reason of kidney graft loss and is caused by immunological and non-immunological factors. There is evidence that mycophenolate mofetil (MMF) may exert a positive effect on renal damage in addition to immunosuppression, by its direct antifibrotic properties. The aim of our study was to retrospectively investigate the role of MMF doses on progression of chronic allograft dysfunction and fibrosis and tubular atrophy (IF/TA). ----- SETTING: Retrospective, cohort study. ----- PARTICIPANTS: Patients with kidney transplant in a tertiary care institution. This is a retrospective cohort study that included 79 patients with kidney and kidney-pancreas transplantation. Immunosuppression consisted of anti-interleukin 2 antibody induction, MMF, a calcineurin inhibitor±steroids. ----- PRIMARY OUTCOME MEASURES: An association of average MMF doses over 1 year post-transplant with progression of interstitial fibrosis (Δci), tubular atrophy (Δct) and estimated-creatinine clearance (eCrcl) at 1 year post-transplant was evaluated using univariate and multivariate analyses. ----- RESULTS: A higher average MMF dose was significantly independently associated with better eCrcl at 1 year post-transplant (b=0.21±0.1, p=0.04). In multiple regression analysis lower Δci (b=-0.2±0.09, p=0.05) and Δct (b=-0.29±0.1, p=0.02) were independently associated with a greater average MMF dose. There was no correlation between average MMF doses and incidence of acute rejection (p=0.68). ----- CONCLUSIONS: A higher average MMF dose over 1 year is associated with better renal function and slower progression of IF/TA, at least partly independent of its immunosuppressive effects.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBMJ Open
Brojčani podacivol. 4, br. 7, e005005
p-ISSN2044-6055
DOIhttps://doi.org/10.1136/bmjopen-2014-005005
URN:NBNurn:nbn:hr:105:820558
Datum objave publikacije2014-07-03
URL dokumentahttps://doi.org/10.1136/bmjopen-2014-005005
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:29:15