prikaz prve stranice dokumenta Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease
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Scientific paper - Review paper
Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease
World Journal of Gastroenterology, 20 (2014), 48; 18070-18091. https://doi.org/10.3748/wjg.v20.i48.18070
Stojsavljević, Sanja; Gomerčić Palčić, Marija; Virović Jukić, Lucija; Smirčić Duvnjak, Lea; Duvnjak, Marko

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Stojsavljević, S., Gomerčić Palčić, M., Virović Jukić, L., Smirčić Duvnjak, L. & Duvnjak, M. (2014). Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease. World Journal of Gastroenterology, 20. (48), 18070-18091. doi: 10.3748/wjg.v20.i48.18070

Stojsavljević, Sanja, et al. "Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease." World Journal of Gastroenterology, vol. 20, no. 48, 2014, pp. 18070-18091. https://doi.org/10.3748/wjg.v20.i48.18070

Stojsavljević, Sanja, Marija Gomerčić Palčić, Lucija Virović Jukić, Lea Smirčić Duvnjak and Marko Duvnjak. "Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease." World Journal of Gastroenterology 20, no. 48 (2014): 18070-18091. https://doi.org/10.3748/wjg.v20.i48.18070

Stojsavljević, S., et al. (2014) 'Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease', World Journal of Gastroenterology, 20(48), pp. 18070-18091. doi: 10.3748/wjg.v20.i48.18070

Stojsavljević S, Gomerčić Palčić M, Virović Jukić L, Smirčić Duvnjak L, Duvnjak M. Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease. World Journal of Gastroenterology [Internet]. 2014 December 28 [cited 2025 February 18];20(48):18070-18091. doi: 10.3748/wjg.v20.i48.18070

S. Stojsavljević, M. Gomerčić Palčić, L. Virović Jukić, L. Smirčić Duvnjak and M. Duvnjak, "Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease", World Journal of Gastroenterology, vol. 20, no. 48, pp. 18070-18091, December 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:630902. [Accessed: 18 February 2025]

Metadata
Title (english)Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease
AuthorSanja Stojsavljević
AuthorMarija Gomerčić Palčić
AuthorLucija Virović Jukić
AuthorLea Smirčić Duvnjak
AuthorMarko Duvnjak
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic steatosis. The pathogenesis of NAFLD and nonalcoholic steatohepatitis (NASH) has not been fully elucidated. The "two-hit" hypothesis is probably a too simplified model to elaborate complex pathogenetic events occurring in patients with NASH. It should be better regarded as a multiple step process, with accumulation of liver fat being the first step, followed by the development of necroinflammation and fibrosis. Adipose tissue, which has emerged as an endocrine organ with a key role in energy homeostasis, is responsive to both central and peripheral metabolic signals and is itself capable of secreting a number of proteins. These adipocyte-specific or enriched proteins, termed adipokines, have been shown to have a variety of local, peripheral, and central effects. In the current review, we explore the role of adipocytokines and proinflammatory cytokines in the pathogenesis of NAFLD. We particularly focus on adiponectin, leptin and ghrelin, with a brief mention of resistin, visfatin and retinol-binding protein 4 among adipokines, and tumor necrosis factor-α, interleukin (IL)-6, IL-1, and briefly IL-18 among proinflammatory cytokines. We update their role in NAFLD, as elucidated in experimental models and clinical practice.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleWorld Journal of Gastroenterology
Numberingvol. 20, no. 48, pp. 18070-18091
p-ISSN1007-9327
DOIhttps://doi.org/10.3748/wjg.v20.i48.18070
URN:NBNurn:nbn:hr:105:630902
Publication2014-12-28
Document URLhttps://doi.org/10.3748/wjg.v20.i48.18070
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:32:52