prikaz prve stranice dokumenta Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease
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Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease
World Journal of Gastroenterology, 20 (2014), 48; 18070-18091. https://doi.org/10.3748/wjg.v20.i48.18070
Stojsavljević, Sanja; Gomerčić Palčić, Marija; Virović Jukić, Lucija; Smirčić Duvnjak, Lea; Duvnjak, Marko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Stojsavljević, S., Gomerčić Palčić, M., Virović Jukić, L., Smirčić Duvnjak, L. i Duvnjak, M. (2014). Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease. World Journal of Gastroenterology, 20. (48), 18070-18091. doi: 10.3748/wjg.v20.i48.18070

Stojsavljević, Sanja, et al. "Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease." World Journal of Gastroenterology, vol. 20, br. 48, 2014, str. 18070-18091. https://doi.org/10.3748/wjg.v20.i48.18070

Stojsavljević, Sanja, Marija Gomerčić Palčić, Lucija Virović Jukić, Lea Smirčić Duvnjak i Marko Duvnjak. "Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease." World Journal of Gastroenterology 20, br. 48 (2014): 18070-18091. https://doi.org/10.3748/wjg.v20.i48.18070

Stojsavljević, S., et al. (2014) 'Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease', World Journal of Gastroenterology, 20(48), str. 18070-18091. doi: 10.3748/wjg.v20.i48.18070

Stojsavljević S, Gomerčić Palčić M, Virović Jukić L, Smirčić Duvnjak L, Duvnjak M. Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease. World Journal of Gastroenterology [Internet]. 28.12.2014. [pristupljeno 23.12.2024.];20(48):18070-18091. doi: 10.3748/wjg.v20.i48.18070

S. Stojsavljević, M. Gomerčić Palčić, L. Virović Jukić, L. Smirčić Duvnjak i M. Duvnjak, "Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease", World Journal of Gastroenterology, vol. 20, br. 48, str. 18070-18091, Prosinac 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:630902. [Citirano: 23.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:630902
Podaci o radu
Naslov (engleski)Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease
AutorSanja Stojsavljević
AutorMarija Gomerčić Palčić
AutorLucija Virović Jukić
AutorLea Smirčić Duvnjak
AutorMarko Duvnjak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic steatosis. The pathogenesis of NAFLD and nonalcoholic steatohepatitis (NASH) has not been fully elucidated. The "two-hit" hypothesis is probably a too simplified model to elaborate complex pathogenetic events occurring in patients with NASH. It should be better regarded as a multiple step process, with accumulation of liver fat being the first step, followed by the development of necroinflammation and fibrosis. Adipose tissue, which has emerged as an endocrine organ with a key role in energy homeostasis, is responsive to both central and peripheral metabolic signals and is itself capable of secreting a number of proteins. These adipocyte-specific or enriched proteins, termed adipokines, have been shown to have a variety of local, peripheral, and central effects. In the current review, we explore the role of adipocytokines and proinflammatory cytokines in the pathogenesis of NAFLD. We particularly focus on adiponectin, leptin and ghrelin, with a brief mention of resistin, visfatin and retinol-binding protein 4 among adipokines, and tumor necrosis factor-α, interleukin (IL)-6, IL-1, and briefly IL-18 among proinflammatory cytokines. We update their role in NAFLD, as elucidated in experimental models and clinical practice.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaWorld Journal of Gastroenterology
Brojčani podacivol. 20, br. 48, str. 18070-18091
p-ISSN1007-9327
DOIhttps://doi.org/10.3748/wjg.v20.i48.18070
URN:NBNurn:nbn:hr:105:630902
Datum objave publikacije2014-12-28
URL dokumentahttps://doi.org/10.3748/wjg.v20.i48.18070
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:32:52