prikaz prve stranice dokumenta VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
  Download
PDF 2.24 MB
Scientific paper - Original scientific paper
VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
Journal of Cell Science, 129 (2016), 1; 206-218. https://doi.org/10.1242/jcs.179960
Benn, Andreas; Bredow, Clara; Casanova, Isabel; Vukičević, Slobodan; Knaus, Petra

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Benn, A., Bredow, C., Casanova, I., Vukičević, S. & Knaus, P. (2016). VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling. Journal of Cell Science, 129. (1), 206-218. doi: 10.1242/jcs.179960

Benn, Andreas, et al. "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling." Journal of Cell Science, vol. 129, no. 1, 2016, pp. 206-218. https://doi.org/10.1242/jcs.179960

Benn, Andreas, Clara Bredow, Isabel Casanova, Slobodan Vukičević and Petra Knaus. "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling." Journal of Cell Science 129, no. 1 (2016): 206-218. https://doi.org/10.1242/jcs.179960

Benn, A., et al. (2016) 'VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling', Journal of Cell Science, 129(1), pp. 206-218. doi: 10.1242/jcs.179960

Benn A, Bredow C, Casanova I, Vukičević S, Knaus P. VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling. Journal of Cell Science [Internet]. 2016 January 01 [cited 2024 May 10];129(1):206-218. doi: 10.1242/jcs.179960

A. Benn, C. Bredow, I. Casanova, S. Vukičević and P. Knaus, "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling", Journal of Cell Science, vol. 129, no. 1, pp. 206-218, January 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:220543. [Accessed: 10 May 2024]

Metadata
Title (english)VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
AuthorAndreas Benn
AuthorClara Bredow
AuthorIsabel Casanova
AuthorSlobodan Vukičević
AuthorPetra Knaus
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Several vascular disorders, such as aberrant angiogenesis, atherosclerosis and pulmonary hypertension, have been linked to dysfunctional BMP signaling. Vascular hyperpermeability via distortion of endothelial cell adherens junctions is a common feature of these diseases, but the role of BMPs in this process has not been investigated. BMP signaling is initiated by binding of ligand to, and activation of, BMP type I (BMPRI) and type II (BMPRII) receptors. Internalization of VE-cadherin as well as c-Src kinase-dependent phosphorylation have been implicated in the loosening of cell-cell contacts, thereby modulating vascular permeability. Here we demonstrate that BMP6 induces hyperpermeabilization of human endothelial cells by inducing internalization and c-Src-dependent phosphorylation of VE-cadherin. Furthermore, we show BMP-dependent physical interaction of VE-cadherin with the BMP receptor ALK2 (BMPRI) and BMPRII, resulting in stabilization of the BMP receptor complex and, thereby, the support of BMP6-Smad signaling. Our results provide first insights into the molecular mechanism of BMP-induced vascular permeability, a hallmark of various vascular diseases, and provide the basis for further investigations of BMPs as regulators of vascular integrity, both under physiological and pathophysiological conditions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Cell Science
Numberingvol. 129, no. 1, pp. 206-218
p-ISSN0021-9533
DOIhttps://doi.org/10.1242/jcs.179960
URN:NBNurn:nbn:hr:105:220543
Publication2016-01-01
Document URLhttps://doi.org/10.1242/jcs.179960
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:33:42