prikaz prve stranice dokumenta VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
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VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
Journal of Cell Science, 129 (2016), 1; 206-218. https://doi.org/10.1242/jcs.179960
Benn, Andreas; Bredow, Clara; Casanova, Isabel; Vukičević, Slobodan; Knaus, Petra

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Benn, A., Bredow, C., Casanova, I., Vukičević, S. i Knaus, P. (2016). VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling. Journal of Cell Science, 129. (1), 206-218. doi: 10.1242/jcs.179960

Benn, Andreas, et al. "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling." Journal of Cell Science, vol. 129, br. 1, 2016, str. 206-218. https://doi.org/10.1242/jcs.179960

Benn, Andreas, Clara Bredow, Isabel Casanova, Slobodan Vukičević i Petra Knaus. "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling." Journal of Cell Science 129, br. 1 (2016): 206-218. https://doi.org/10.1242/jcs.179960

Benn, A., et al. (2016) 'VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling', Journal of Cell Science, 129(1), str. 206-218. doi: 10.1242/jcs.179960

Benn A, Bredow C, Casanova I, Vukičević S, Knaus P. VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling. Journal of Cell Science [Internet]. 01.01.2016. [pristupljeno 29.11.2024.];129(1):206-218. doi: 10.1242/jcs.179960

A. Benn, C. Bredow, I. Casanova, S. Vukičević i P. Knaus, "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling", Journal of Cell Science, vol. 129, br. 1, str. 206-218, Siječanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:220543. [Citirano: 29.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:220543
Podaci o radu
Naslov (engleski)VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
AutorAndreas Benn
AutorClara Bredow
AutorIsabel Casanova
AutorSlobodan Vukičević
AutorPetra Knaus
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Several vascular disorders, such as aberrant angiogenesis, atherosclerosis and pulmonary hypertension, have been linked to dysfunctional BMP signaling. Vascular hyperpermeability via distortion of endothelial cell adherens junctions is a common feature of these diseases, but the role of BMPs in this process has not been investigated. BMP signaling is initiated by binding of ligand to, and activation of, BMP type I (BMPRI) and type II (BMPRII) receptors. Internalization of VE-cadherin as well as c-Src kinase-dependent phosphorylation have been implicated in the loosening of cell-cell contacts, thereby modulating vascular permeability. Here we demonstrate that BMP6 induces hyperpermeabilization of human endothelial cells by inducing internalization and c-Src-dependent phosphorylation of VE-cadherin. Furthermore, we show BMP-dependent physical interaction of VE-cadherin with the BMP receptor ALK2 (BMPRI) and BMPRII, resulting in stabilization of the BMP receptor complex and, thereby, the support of BMP6-Smad signaling. Our results provide first insights into the molecular mechanism of BMP-induced vascular permeability, a hallmark of various vascular diseases, and provide the basis for further investigations of BMPs as regulators of vascular integrity, both under physiological and pathophysiological conditions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Cell Science
Brojčani podacivol. 129, br. 1, str. 206-218
p-ISSN0021-9533
DOIhttps://doi.org/10.1242/jcs.179960
URN:NBNurn:nbn:hr:105:220543
Datum objave publikacije2016-01-01
URL dokumentahttps://doi.org/10.1242/jcs.179960
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:33:42