prikaz prve stranice dokumenta Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study
  Download
PDF 1002.85 KB
Scientific paper - Original scientific paper
Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study
Annals of Clinical Microbiology and Antimicrobials, 14 (2015); 47. https://doi.org/10.1186/s12941-015-0107-z
Senbayrak, Seniha; Ozkutuk, Nuri; Erdem, Hakan; Johansen, Isik Somuncu; Čivljak, Rok; Inal, Ayse Seza; Kayabas, Uner; Kursun, Ebru; Elaldi, Nazif; Savić, Branislava; Simeon, Soline; Yilmaz, Emel; Dulović, Olga; Ozturk-Engin, Derya; Ceran, Nurgul; Lakatos, Botond; Sipahi, Oguz Resat; Sunbul, Mustafa; Yemisen, Mucahit; Alabay, Selma; Beović, Bojana; Ulu-Kilic, Aysegul; Cag, Yasemin; Catroux, Melanie; Inan, Asuman; Dragovac, Gorana; Deveci, Ozcan; Tekin, Recep; Gul, Hanefi Cem; Sengoz, Gonul; Andre, Katell; Harxhi, Arjan; Hansmann, Yves; Oncu, Serkan; Kose, Sukran; Oncul, Oral; Parlak, Emine; Sener, Alper; Yilmaz, Gulden; Savasci, Umit; Vahaboglu, Haluk More authors...

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Senbayrak, S., Ozkutuk, N., Erdem, H., Johansen, I. S., Čivljak, R., Inal, A. S. ... Vahaboglu, H. (2015). Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study. Annals of Clinical Microbiology and Antimicrobials, 14., 47. doi: 10.1186/s12941-015-0107-z

Senbayrak, Seniha, et al. "Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study." Annals of Clinical Microbiology and Antimicrobials, vol. 14, 2015, p. 47. https://doi.org/10.1186/s12941-015-0107-z

Senbayrak, Seniha, Nuri Ozkutuk, Hakan Erdem, Isik Somuncu Johansen, Rok Čivljak, Ayse Seza Inal, Uner Kayabas, et al. "Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study." Annals of Clinical Microbiology and Antimicrobials 14 (2015): 47. https://doi.org/10.1186/s12941-015-0107-z

Senbayrak, S., et al. (2015) 'Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study', Annals of Clinical Microbiology and Antimicrobials, 14, p. 47. doi: 10.1186/s12941-015-0107-z

Senbayrak S, Ozkutuk N, Erdem H, Johansen IS, Čivljak R, Inal AS, and sur.. Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study. Annals of Clinical Microbiology and Antimicrobials [Internet]. 2015 November 04 [cited 2024 August 06];14:47. doi: 10.1186/s12941-015-0107-z

S. Senbayrak, et al., "Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study", Annals of Clinical Microbiology and Antimicrobials, vol. 14, p. 47, November 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:447414. [Accessed: 06 August 2024]

Metadata
Title (english)Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study
AuthorSeniha Senbayrak
AuthorNuri Ozkutuk
AuthorHakan Erdem
AuthorIsik Somuncu Johansen
AuthorRok Čivljak
AuthorAyse Seza Inal
AuthorUner Kayabas
AuthorEbru Kursun
AuthorNazif Elaldi
AuthorBranislava Savić
AuthorSoline Simeon
AuthorEmel Yilmaz
AuthorOlga Dulović
AuthorDerya Ozturk-Engin
AuthorNurgul Ceran
AuthorBotond Lakatos
AuthorOguz Resat Sipahi
AuthorMustafa Sunbul
AuthorMucahit Yemisen
AuthorSelma Alabay
AuthorBojana Beović
AuthorAysegul Ulu-Kilic
AuthorYasemin Cag
AuthorMelanie Catroux
AuthorAsuman Inan
AuthorGorana Dragovac
AuthorOzcan Deveci
AuthorRecep Tekin
AuthorHanefi Cem Gul
AuthorGonul Sengoz
AuthorKatell Andre
AuthorArjan Harxhi
AuthorYves Hansmann
AuthorSerkan Oncu
AuthorSukran Kose
AuthorOral Oncul
AuthorEmine Parlak
AuthorAlper Sener
AuthorGulden Yilmaz
AuthorUmit Savasci
AuthorHaluk Vahaboglu
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to antituberculosis drugs is an increasingly common clinical problem. This study aimed to evaluate drug resistance profiles of TBM isolates in adult patients in nine European countries involving 32 centers to provide insight into the empiric treatment of TBM. ----- METHODS: Mycobacterium tuberculosis was cultured from the cerebrospinal fluid (CSF) of 142 patients and was tested for susceptibility to first-line antituberculosis drugs, streptomycin (SM), isoniazid (INH), rifampicin (RIF) and ethambutol (EMB). ----- RESULTS: Twenty of 142 isolates (14.1 %) were resistant to at least one antituberculosis drug, and five (3.5 %) were resistant to at least INH and RIF, [multidrug resistant (MDR)]. The resistance rate was 12, 4.9, 4.2 and 3.5 % for INH, SM, EMB and RIF, respectively. The monoresistance rate was 6.3, 1.4 and 0.7 % for INH, SM and EMB respectively. There was no monoresistance to RIF. The mortality rate was 23.8 % in fully susceptible cases while it was 33.3 % for those exhibiting monoresistance to INH, and 40 % in cases with MDR-TBM. In compared to patients without resistance to any first-line drug, the relative risk of death for INH-monoresistance and MDR-TBM was 1.60 (95 % CI, 0.38-6.82) and 2.14 (95 % CI, 0:34-13:42), respectively. ----- CONCLUSION: INH-resistance and MDR rates seemed not to be worrisome in our study. However, considering their adverse effects on treatment, rapid detection of resistance to at least INH and RIF would be most beneficial for designing anti-TB therapy. Still, empiric TBM treatment should be started immediately without waiting the drug susceptibility testing.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAnnals of Clinical Microbiology and Antimicrobials
Numberingvol. 14, p. 47
p-ISSN1476-0711
DOIhttps://doi.org/10.1186/s12941-015-0107-z
URN:NBNurn:nbn:hr:105:447414
Publication2015-11-04
Document URLhttps://doi.org/10.1186/s12941-015-0107-z
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:34:04