prikaz prve stranice dokumenta Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study
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Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study
Annals of Clinical Microbiology and Antimicrobials, 14 (2015); 47. https://doi.org/10.1186/s12941-015-0107-z
Senbayrak, Seniha; Ozkutuk, Nuri; Erdem, Hakan; Johansen, Isik Somuncu; Čivljak, Rok; Inal, Ayse Seza; Kayabas, Uner; Kursun, Ebru; Elaldi, Nazif; Savić, Branislava; Simeon, Soline; Yilmaz, Emel; Dulović, Olga; Ozturk-Engin, Derya; Ceran, Nurgul; Lakatos, Botond; Sipahi, Oguz Resat; Sunbul, Mustafa; Yemisen, Mucahit; Alabay, Selma; Beović, Bojana; Ulu-Kilic, Aysegul; Cag, Yasemin; Catroux, Melanie; Inan, Asuman; Dragovac, Gorana; Deveci, Ozcan; Tekin, Recep; Gul, Hanefi Cem; Sengoz, Gonul; Andre, Katell; Harxhi, Arjan; Hansmann, Yves; Oncu, Serkan; Kose, Sukran; Oncul, Oral; Parlak, Emine; Sener, Alper; Yilmaz, Gulden; Savasci, Umit; Vahaboglu, Haluk Više autora...

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Senbayrak, S., Ozkutuk, N., Erdem, H., Johansen, I. S., Čivljak, R., Inal, A. S. ... Vahaboglu, H. (2015). Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study. Annals of Clinical Microbiology and Antimicrobials, 14., 47. doi: 10.1186/s12941-015-0107-z

Senbayrak, Seniha, et al. "Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study." Annals of Clinical Microbiology and Antimicrobials, vol. 14, 2015, str. 47. https://doi.org/10.1186/s12941-015-0107-z

Senbayrak, Seniha, Nuri Ozkutuk, Hakan Erdem, Isik Somuncu Johansen, Rok Čivljak, Ayse Seza Inal, Uner Kayabas, et al. "Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study." Annals of Clinical Microbiology and Antimicrobials 14 (2015): 47. https://doi.org/10.1186/s12941-015-0107-z

Senbayrak, S., et al. (2015) 'Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study', Annals of Clinical Microbiology and Antimicrobials, 14, str. 47. doi: 10.1186/s12941-015-0107-z

Senbayrak S, Ozkutuk N, Erdem H, Johansen IS, Čivljak R, Inal AS, i sur.. Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study. Annals of Clinical Microbiology and Antimicrobials [Internet]. 04.11.2015. [pristupljeno 27.04.2024.];14:47. doi: 10.1186/s12941-015-0107-z

S. Senbayrak, et al., "Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study", Annals of Clinical Microbiology and Antimicrobials, vol. 14, str. 47, Studeni 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:447414. [Citirano: 27.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:447414
Podaci o radu
Naslov (engleski)Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study
AutorSeniha Senbayrak
AutorNuri Ozkutuk
AutorHakan Erdem
AutorIsik Somuncu Johansen
AutorRok Čivljak
AutorAyse Seza Inal
AutorUner Kayabas
AutorEbru Kursun
AutorNazif Elaldi
AutorBranislava Savić
AutorSoline Simeon
AutorEmel Yilmaz
AutorOlga Dulović
AutorDerya Ozturk-Engin
AutorNurgul Ceran
AutorBotond Lakatos
AutorOguz Resat Sipahi
AutorMustafa Sunbul
AutorMucahit Yemisen
AutorSelma Alabay
AutorBojana Beović
AutorAysegul Ulu-Kilic
AutorYasemin Cag
AutorMelanie Catroux
AutorAsuman Inan
AutorGorana Dragovac
AutorOzcan Deveci
AutorRecep Tekin
AutorHanefi Cem Gul
AutorGonul Sengoz
AutorKatell Andre
AutorArjan Harxhi
AutorYves Hansmann
AutorSerkan Oncu
AutorSukran Kose
AutorOral Oncul
AutorEmine Parlak
AutorAlper Sener
AutorGulden Yilmaz
AutorUmit Savasci
AutorHaluk Vahaboglu
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to antituberculosis drugs is an increasingly common clinical problem. This study aimed to evaluate drug resistance profiles of TBM isolates in adult patients in nine European countries involving 32 centers to provide insight into the empiric treatment of TBM. ----- METHODS: Mycobacterium tuberculosis was cultured from the cerebrospinal fluid (CSF) of 142 patients and was tested for susceptibility to first-line antituberculosis drugs, streptomycin (SM), isoniazid (INH), rifampicin (RIF) and ethambutol (EMB). ----- RESULTS: Twenty of 142 isolates (14.1 %) were resistant to at least one antituberculosis drug, and five (3.5 %) were resistant to at least INH and RIF, [multidrug resistant (MDR)]. The resistance rate was 12, 4.9, 4.2 and 3.5 % for INH, SM, EMB and RIF, respectively. The monoresistance rate was 6.3, 1.4 and 0.7 % for INH, SM and EMB respectively. There was no monoresistance to RIF. The mortality rate was 23.8 % in fully susceptible cases while it was 33.3 % for those exhibiting monoresistance to INH, and 40 % in cases with MDR-TBM. In compared to patients without resistance to any first-line drug, the relative risk of death for INH-monoresistance and MDR-TBM was 1.60 (95 % CI, 0.38-6.82) and 2.14 (95 % CI, 0:34-13:42), respectively. ----- CONCLUSION: INH-resistance and MDR rates seemed not to be worrisome in our study. However, considering their adverse effects on treatment, rapid detection of resistance to at least INH and RIF would be most beneficial for designing anti-TB therapy. Still, empiric TBM treatment should be started immediately without waiting the drug susceptibility testing.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAnnals of Clinical Microbiology and Antimicrobials
Brojčani podacivol. 14, str. 47
p-ISSN1476-0711
DOIhttps://doi.org/10.1186/s12941-015-0107-z
URN:NBNurn:nbn:hr:105:447414
Datum objave publikacije2015-11-04
URL dokumentahttps://doi.org/10.1186/s12941-015-0107-z
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:34:04