prikaz prve stranice dokumenta Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease
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Scientific paper - Original scientific paper
Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease
Journal of Neural Transmission, 122 (2015), 4; 577-592. https://doi.org/10.1007/s00702-015-1394-4
Knezović, Ana; Osmanović-Barilar, Jelena; Ćurlin, Marija; Hof, Patrick R.; Šimić, Goran; Riederer, Peter; Šalković-Petrišić, Melita

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Knezović, A., Osmanović Barilar, J., Ćurlin, M., Hof, P. R., Šimić, G., Riederer, P. & Šalković Petrišić, M. (2015). Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease. Journal of Neural Transmission, 122. (4), 577-592. doi: 10.1007/s00702-015-1394-4

Knezović, Ana, et al. "Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease." Journal of Neural Transmission, vol. 122, no. 4, 2015, pp. 577-592. https://doi.org/10.1007/s00702-015-1394-4

Knezović, Ana, Jelena Osmanović Barilar, Marija Ćurlin, Patrick R. Hof, Goran Šimić, Peter Riederer and Melita Šalković Petrišić. "Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease." Journal of Neural Transmission 122, no. 4 (2015): 577-592. https://doi.org/10.1007/s00702-015-1394-4

Knezović, A., et al. (2015) 'Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease', Journal of Neural Transmission, 122(4), pp. 577-592. doi: 10.1007/s00702-015-1394-4

Knezović A, Osmanović Barilar J, Ćurlin M, Hof PR, Šimić G, Riederer P, and sur.. Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease. Journal of Neural Transmission [Internet]. 2015 April [cited 2024 November 22];122(4):577-592. doi: 10.1007/s00702-015-1394-4

A. Knezović, et al., "Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease", Journal of Neural Transmission, vol. 122, no. 4, pp. 577-592, April 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:301217. [Accessed: 22 November 2024]

Metadata
Title (english)Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease
AuthorAna Knezović
AuthorJelena Osmanović-Barilar
AuthorMarija Ćurlin
AuthorPatrick R. Hof
AuthorGoran Šimić
AuthorPeter Riederer
AuthorMelita Šalković-Petrišić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Sporadic Alzheimer's disease (sAD) is the most common form of dementia. Rats injected intracerebroventricularly with streptozotocin (STZ-icv) develop insulin-resistant brain state and represent a non-transgenic sAD model with a number of AD-like cognitive and neurochemical features. We explored cognitive, structural and ultrastructural changes in the brain of the STZ-icv rat model over a course of 9 months. Cognitive functions were measured in the STZ-icv- (0.3, 1 and 3 mg/kg) and age-matched control rats by passive avoidance test. Structural changes were assessed by Nissl and Bielschowsky silver staining. Immunohistochemistry and electron microscopy analysis were used to detect amyloid β- (Aβ(1-42)) and hyperphosphorylated tau (AT8) accumulation and ultrastructural changes in the brain. Memory decline was time- (≤3 months/acute, ≥3 months/progressive) and STZ-icv dose-dependent. Morphological changes were manifested as thinning of parietal cortex (≥1 month) and corpus callosum (9 months), and were more pronounced in the 3 mg/kg STZ group. Early neurofibrillary changes (AT8) were detected from 1 month onward in the neocortex, and progressed after 3 months to the hippocampus. Intracellular Aβ(1-42) accumulation was found in the neocortex at 3 months following STZ-icv treatment, while diffuse Aβ(1-42)-positive plaque-like formations were found after 6 months in the neocortex and hippocampus. Ultrastructural changes revealed enlargement of Golgi apparatus, pyknotic nuclei, and time-dependent increase in lysosome size, number, and density. Our data provide a staging of cognitive, structural/ultrastructural, and neuropathological markers in the STZ-icv rat model that in many aspects seems to be generally comparable to stages seen in human sAD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Neural Transmission
Numberingvol. 122, no. 4, pp. 577-592
p-ISSN0300-9564
DOIhttps://doi.org/10.1007/s00702-015-1394-4
URN:NBNurn:nbn:hr:105:301217
Publication2015-04
Document URLhttps://doi.org/10.1007/s00702-015-1394-4
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:37:30