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Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease
Journal of Neural Transmission, 122 (2015), 4; 577-592. https://doi.org/10.1007/s00702-015-1394-4
Knezović, Ana; Osmanović-Barilar, Jelena; Ćurlin, Marija; Hof, Patrick R.; Šimić, Goran; Riederer, Peter; Šalković-Petrišić, Melita

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Knezović, A., Osmanović Barilar, J., Ćurlin, M., Hof, P. R., Šimić, G., Riederer, P. i Šalković Petrišić, M. (2015). Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease. Journal of Neural Transmission, 122. (4), 577-592. doi: 10.1007/s00702-015-1394-4

Knezović, Ana, et al. "Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease." Journal of Neural Transmission, vol. 122, br. 4, 2015, str. 577-592. https://doi.org/10.1007/s00702-015-1394-4

Knezović, Ana, Jelena Osmanović Barilar, Marija Ćurlin, Patrick R. Hof, Goran Šimić, Peter Riederer i Melita Šalković Petrišić. "Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease." Journal of Neural Transmission 122, br. 4 (2015): 577-592. https://doi.org/10.1007/s00702-015-1394-4

Knezović, A., et al. (2015) 'Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease', Journal of Neural Transmission, 122(4), str. 577-592. doi: 10.1007/s00702-015-1394-4

Knezović A, Osmanović Barilar J, Ćurlin M, Hof PR, Šimić G, Riederer P, i sur.. Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease. Journal of Neural Transmission [Internet]. 04.2015. [pristupljeno 04.05.2024.];122(4):577-592. doi: 10.1007/s00702-015-1394-4

A. Knezović, et al., "Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease", Journal of Neural Transmission, vol. 122, br. 4, str. 577-592, Travanj 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:301217. [Citirano: 04.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:301217
Podaci o radu
Naslov (engleski)Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease
AutorAna Knezović
AutorJelena Osmanović-Barilar
AutorMarija Ćurlin
AutorPatrick R. Hof
AutorGoran Šimić
AutorPeter Riederer
AutorMelita Šalković-Petrišić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Sporadic Alzheimer's disease (sAD) is the most common form of dementia. Rats injected intracerebroventricularly with streptozotocin (STZ-icv) develop insulin-resistant brain state and represent a non-transgenic sAD model with a number of AD-like cognitive and neurochemical features. We explored cognitive, structural and ultrastructural changes in the brain of the STZ-icv rat model over a course of 9 months. Cognitive functions were measured in the STZ-icv- (0.3, 1 and 3 mg/kg) and age-matched control rats by passive avoidance test. Structural changes were assessed by Nissl and Bielschowsky silver staining. Immunohistochemistry and electron microscopy analysis were used to detect amyloid β- (Aβ(1-42)) and hyperphosphorylated tau (AT8) accumulation and ultrastructural changes in the brain. Memory decline was time- (≤3 months/acute, ≥3 months/progressive) and STZ-icv dose-dependent. Morphological changes were manifested as thinning of parietal cortex (≥1 month) and corpus callosum (9 months), and were more pronounced in the 3 mg/kg STZ group. Early neurofibrillary changes (AT8) were detected from 1 month onward in the neocortex, and progressed after 3 months to the hippocampus. Intracellular Aβ(1-42) accumulation was found in the neocortex at 3 months following STZ-icv treatment, while diffuse Aβ(1-42)-positive plaque-like formations were found after 6 months in the neocortex and hippocampus. Ultrastructural changes revealed enlargement of Golgi apparatus, pyknotic nuclei, and time-dependent increase in lysosome size, number, and density. Our data provide a staging of cognitive, structural/ultrastructural, and neuropathological markers in the STZ-icv rat model that in many aspects seems to be generally comparable to stages seen in human sAD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Neural Transmission
Brojčani podacivol. 122, br. 4, str. 577-592
p-ISSN0300-9564
DOIhttps://doi.org/10.1007/s00702-015-1394-4
URN:NBNurn:nbn:hr:105:301217
Datum objave publikacije2015-04
URL dokumentahttps://doi.org/10.1007/s00702-015-1394-4
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:37:30