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Scientific paper - Original scientific paper
Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis
Journal of the European Academy of Dermatology and Venereology, 20 (2006), 1; 51-57. https://doi.org/10.1111/j.1468-3083.2005.01364.x
Tomas, Davor; Krušlin, Božo; Čupić, Hrvoje; Stanimirović, Andrija; Bošnjak, Berislav; Lovričević, Ivo; Belicza, Mladen

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Tomas, D., Krušlin, B., Čupić, H., Stanimirović, A., Bošnjak, B., Lovričević, I. & Belicza, M. (2006). Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis. Journal of the European Academy of Dermatology and Venereology, 20. (1), 51-57. doi: 10.1111/j.1468-3083.2005.01364.x

Tomas, Davor, et al. "Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis." Journal of the European Academy of Dermatology and Venereology, vol. 20, no. 1, 2006, pp. 51-57. https://doi.org/10.1111/j.1468-3083.2005.01364.x

Tomas, Davor, Božo Krušlin, Hrvoje Čupić, Andrija Stanimirović, Berislav Bošnjak, Ivo Lovričević and Mladen Belicza. "Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis." Journal of the European Academy of Dermatology and Venereology 20, no. 1 (2006): 51-57. https://doi.org/10.1111/j.1468-3083.2005.01364.x

Tomas, D., et al. (2006) 'Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis', Journal of the European Academy of Dermatology and Venereology, 20(1), pp. 51-57. doi: 10.1111/j.1468-3083.2005.01364.x

Tomas D, Krušlin B, Čupić H, Stanimirović A, Bošnjak B, Lovričević I, and sur.. Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis. Journal of the European Academy of Dermatology and Venereology [Internet]. 2006 January [cited 2024 December 27];20(1):51-57. doi: 10.1111/j.1468-3083.2005.01364.x

D. Tomas, et al., "Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis", Journal of the European Academy of Dermatology and Venereology, vol. 20, no. 1, pp. 51-57, January 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:208343. [Accessed: 27 December 2024]

Metadata
Title (english)Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis
AuthorDavor Tomas
AuthorBožo Krušlin
AuthorHrvoje Čupić
AuthorAndrija Stanimirović
AuthorBerislav Bošnjak
AuthorIvo Lovričević
AuthorMladen Belicza
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Recent investigations consider actinic keratosis (AK) as an earliest visible pattern of squamous cell carcinoma (SCC). We have analysed the expression of apoptosis-related proteins TP53, Bcl-2 and Bax in 30 atrophic and 30 hypertrophic AK cases. ----- MATERIAL AND METHODS: Immunohistochemical analysis was performed following microwave streptavidin immunoperoxidase protocol on DAKO TechMate Horizon automated immunostainer (DAKO, Copenhagen, Denmark). Monoclonal antibody for TP53 and Bcl-2 and polyclonal antibody for Bax (DAKO, Copenhagen, Denmark) were used. ----- RESULTS: Expression of TP53 showed no significant differences between two analysed groups (chi2-test, P = 0.35636) whereas expression of Bcl-2 and Bax protein was significantly higher in atrophic compared to hypertrophic AK (chi2-test, P = 0.01458 and P = 0.00358, respectively). Comparison of Bcl-2 : Bax ratio in two analysed AK showed significantly higher value in hypertrophic compared to atrophic AK (Mann-Whitney U test, P = 0.02272). Statistical analysis did not show any correlation between patient's sex and age, localization and size of the lesion with expression of investigated oncoproteins (anova, P > 0.05). ----- CONCLUSIONS: Our results may indicate higher resistance of keratinocytes on apoptotic stimuli in hypertrophic compared to atrophic AK. Thus, we suppose that keratinocytes in hypertrophic AK live longer and probably have higher propensity for additional mutations and conversion to overt SCC.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of the European Academy of Dermatology and Venereology
Numberingvol. 20, no. 1, pp. 51-57
p-ISSN0926-9959
DOIhttps://doi.org/10.1111/j.1468-3083.2005.01364.x
URN:NBNurn:nbn:hr:105:208343
Publication2006-01
Document URLhttps://doi.org/10.1111/j.1468-3083.2005.01364.x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:39:22