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Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis
Journal of the European Academy of Dermatology and Venereology, 20 (2006), 1; 51-57. https://doi.org/10.1111/j.1468-3083.2005.01364.x
Tomas, Davor; Krušlin, Božo; Čupić, Hrvoje; Stanimirović, Andrija; Bošnjak, Berislav; Lovričević, Ivo; Belicza, Mladen

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Tomas, D., Krušlin, B., Čupić, H., Stanimirović, A., Bošnjak, B., Lovričević, I. i Belicza, M. (2006). Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis. Journal of the European Academy of Dermatology and Venereology, 20. (1), 51-57. doi: 10.1111/j.1468-3083.2005.01364.x

Tomas, Davor, et al. "Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis." Journal of the European Academy of Dermatology and Venereology, vol. 20, br. 1, 2006, str. 51-57. https://doi.org/10.1111/j.1468-3083.2005.01364.x

Tomas, Davor, Božo Krušlin, Hrvoje Čupić, Andrija Stanimirović, Berislav Bošnjak, Ivo Lovričević i Mladen Belicza. "Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis." Journal of the European Academy of Dermatology and Venereology 20, br. 1 (2006): 51-57. https://doi.org/10.1111/j.1468-3083.2005.01364.x

Tomas, D., et al. (2006) 'Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis', Journal of the European Academy of Dermatology and Venereology, 20(1), str. 51-57. doi: 10.1111/j.1468-3083.2005.01364.x

Tomas D, Krušlin B, Čupić H, Stanimirović A, Bošnjak B, Lovričević I, i sur.. Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis. Journal of the European Academy of Dermatology and Venereology [Internet]. 01.2006. [pristupljeno 14.05.2024.];20(1):51-57. doi: 10.1111/j.1468-3083.2005.01364.x

D. Tomas, et al., "Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis", Journal of the European Academy of Dermatology and Venereology, vol. 20, br. 1, str. 51-57, Siječanj 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:208343. [Citirano: 14.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:208343
Podaci o radu
Naslov (engleski)Correlation between Bcl-2 and Bax in atrophic and hypertrophic type of actinic keratosis
AutorDavor Tomas
AutorBožo Krušlin
AutorHrvoje Čupić
AutorAndrija Stanimirović
AutorBerislav Bošnjak
AutorIvo Lovričević
AutorMladen Belicza
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Recent investigations consider actinic keratosis (AK) as an earliest visible pattern of squamous cell carcinoma (SCC). We have analysed the expression of apoptosis-related proteins TP53, Bcl-2 and Bax in 30 atrophic and 30 hypertrophic AK cases. ----- MATERIAL AND METHODS: Immunohistochemical analysis was performed following microwave streptavidin immunoperoxidase protocol on DAKO TechMate Horizon automated immunostainer (DAKO, Copenhagen, Denmark). Monoclonal antibody for TP53 and Bcl-2 and polyclonal antibody for Bax (DAKO, Copenhagen, Denmark) were used. ----- RESULTS: Expression of TP53 showed no significant differences between two analysed groups (chi2-test, P = 0.35636) whereas expression of Bcl-2 and Bax protein was significantly higher in atrophic compared to hypertrophic AK (chi2-test, P = 0.01458 and P = 0.00358, respectively). Comparison of Bcl-2 : Bax ratio in two analysed AK showed significantly higher value in hypertrophic compared to atrophic AK (Mann-Whitney U test, P = 0.02272). Statistical analysis did not show any correlation between patient's sex and age, localization and size of the lesion with expression of investigated oncoproteins (anova, P > 0.05). ----- CONCLUSIONS: Our results may indicate higher resistance of keratinocytes on apoptotic stimuli in hypertrophic compared to atrophic AK. Thus, we suppose that keratinocytes in hypertrophic AK live longer and probably have higher propensity for additional mutations and conversion to overt SCC.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of the European Academy of Dermatology and Venereology
Brojčani podacivol. 20, br. 1, str. 51-57
p-ISSN0926-9959
DOIhttps://doi.org/10.1111/j.1468-3083.2005.01364.x
URN:NBNurn:nbn:hr:105:208343
Datum objave publikacije2006-01
URL dokumentahttps://doi.org/10.1111/j.1468-3083.2005.01364.x
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:39:22