prikaz prve stranice dokumenta High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease
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Scientific paper - Original scientific paper
High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease
Croatian Medical Journal, 57 (2016), 3; 229-238. https://doi.org/10.3325/cmj.2016.57.229
Čeović, Romana; Desnica, Lana; Pulanić, Dražen; Serventi Seiwerth, Ranka; Ilić, Ivana; Grce, Magdalena; Mravak Stipetić, Marinka; Klepac Pulanić, Tajana; Bilić, Ervina; Bilić, Ernest; Milošević, Milan; Vrhovac, Radovan; Nemet, Damir; Pavletic, Steven Z

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Čeović, R., Desnica, L., Pulanić, D., Serventi Seiwerth, R., Ilić, I., Grce, M. ... Pavletic, S. Z. (2016). High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease. Croatian Medical Journal, 57. (3), 229-238. doi: 10.3325/cmj.2016.57.229

Čeović, Romana, et al. "High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease." Croatian Medical Journal, vol. 57, no. 3, 2016, pp. 229-238. https://doi.org/10.3325/cmj.2016.57.229

Čeović, Romana, Lana Desnica, Dražen Pulanić, Ranka Serventi Seiwerth, Ivana Ilić, Magdalena Grce, Marinka Mravak Stipetić, et al. "High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease." Croatian Medical Journal 57, no. 3 (2016): 229-238. https://doi.org/10.3325/cmj.2016.57.229

Čeović, R., et al. (2016) 'High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease', Croatian Medical Journal, 57(3), pp. 229-238. doi: 10.3325/cmj.2016.57.229

Čeović R, Desnica L, Pulanić D, Serventi Seiwerth R, Ilić I, Grce M, and sur.. High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease. Croatian Medical Journal [Internet]. 2016 June [cited 2025 February 17];57(3):229-238. doi: 10.3325/cmj.2016.57.229

R. Čeović, et al., "High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease", Croatian Medical Journal, vol. 57, no. 3, pp. 229-238, June 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:491126. [Accessed: 17 February 2025]

Metadata
Title (english)High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease
AuthorRomana Čeović
AuthorLana Desnica
AuthorDražen Pulanić
AuthorRanka Serventi Seiwerth
AuthorIvana Ilić
AuthorMagdalena Grce
AuthorMarinka Mravak Stipetić
AuthorTajana Klepac Pulanić
AuthorErvina Bilić
AuthorErnest Bilić
AuthorMilan Milošević
AuthorRadovan Vrhovac
AuthorDamir Nemet
AuthorSteven Z Pavletic
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To determine the frequency and the characteristics of cutaneous manifestations, especially vitiligo and alopecia areata, in patients with chronic graft-vs-host disease (cGVHD). ----- METHODS: 50 patients with cGVHD were prospectively enrolled in the observational study protocol and evaluated by an experienced dermatologist. The evaluation was focused on the clinical spectrum of skin and adnexal involvement, and the cutaneous GVHD score was determined according to National Institutes of Health (NIH) Consensus criteria. The presence of vitiligo, alopecia, xerosis, nail changes, and dyspigmentation was also assessed. ----- RESULTS: Out of 50 cGVHD patients, 28 (56%) had skin involvement, and 27 of them (96%) had hypo and/or hyperpigmentations. 11 patients (39%) had a mild cutaneous NIH cGVHD score, 22% moderate, and 39% severe. 15 (30%) patients had nail changes and 10 (20%) had vitiligo or alopecia areata. Univariate analysis showed that patients with vitiligo/alopecia areata received more lines of prior systemic immunosuppressive therapy (P=0.043), had lower Karnofsky performance status (P=0.028), and had a higher B-cell number (P=0.005), platelet count (P=0.022), and total protein (P=0.024). Vitiligo and alopecia areata were associated with higher NIH skin score (P=0.001), higher intensity of immunosuppressive treatment (P=0.020), and total body irradiation conditioning (P=0.040). Multivariate regression model showed that patients with higher NIH skin scoring were 3.67 times more likely to have alopecia and/or vitiligo (odds ratio 3.67; 95% confidence interval 1.26-10.73), controlled for all other factors in the model (age at study entry, number of B-cells, platelet count, and global NIH score). ----- CONCLUSION: These data indicate that vitiligo and alopecia areata occur more frequently in cGVHD than previously reported.
Abstract (croatian)
Visoka učestalost kožnih manifestacija, uključujući vitiligo i alopeciju areatu, u prospektivno prikupljenoj skupini pacijenata s kroničnom bolešću presatka protiv domaćina ----- Cilj: Odrediti učestalost i obilježja kožnih manifestacija, posebice vitiliga i alopecije areate, kod pacijenata s kroničnom bolešću presatka protiv domaćina (prema engl. chronic graft-versus-host disease, cGVHD). ----- Postupci: Opservacijsko istraživanje prospektivno je uključilo 50 pacijenata s cGVHD koje je pregledao iskusni dermatolog. Evaluacija je bila usmjerena na kliničke znakove zahvaćenosti kože i adneksa te je utvrđen kožni GVHD izračun prema kriterijima Nacionalnih instituta za zdravlje SAD-a (prema engl. National Institutes of Health, NIH). Odredili smo prisutnost vitiliga, alopecije, kseroze, promjena noktiju i depigmentacije. ----- Rezultati: Od 50 cGVHD pacijenata, 28 (56%) je imalo zahvaćenu kožu, dok je 27 od njih (96%) imalo hipo i/ili hiperpigmentacije. Prema kožnom NIH cGVHD izračunu, 11 pacijenata (39%) imalo je blagi oblik bolesti, 22% umjereni, a 39% teški oblik bolesti. 15 (30%) pacijenata imalo je promjene noktiju, dok ih je 10 (20%) imalo vitiligo ili alopeciju areatu. Univarijatna analiza pokazala je da su pacijenti s vitiligom/alopecijom areatom primili više linija sustavne imunosupresivne terapije (P=0,043), imali niži Karnofsky izvedbeni status (P=0,028) te veći broj B limfocita (P=0,005), trombocita (P=0,022) i ukupnih proteina (P=0,024). Vitiligo i alopecija areata bili su povezani s višim NIH kožnim izračunom (P=0,001), većim intenzitetom imunosupresivne terapije (P=0,020) i zračenjem cijelog tijela (P=0,040). Multivarijatni regresijski model pokazao je da su pacijenti s višim NIH kožnim izračunom imali 3,67 puta veće izglede da dobiju alopeciju i/ili vitiligo (omjer izgleda 3,67; 95% raspon pouzdanosti 1,26-10,73), uz kontroliranje svih ostalih čimbenika u modelu (dob pri uključenju u istraživanje, broj B stanica, broj krvnih pločica, i ukupni NIH izračun). ----- Zaključak: Naši podaci pokazali su veći broj cGVHD pacijenata s vitiligom i alopecijom nego što je to ranije opaženo.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 57, no. 3, pp. 229-238
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2016.57.229
URN:NBNurn:nbn:hr:105:491126
Publication2016-06
Document URLhttp://doi.org/10.3325/cmj.2016.57.229
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:43:15