prikaz prve stranice dokumenta High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease
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High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease
Croatian Medical Journal, 57 (2016), 3; 229-238. https://doi.org/10.3325/cmj.2016.57.229
Čeović, Romana; Desnica, Lana; Pulanić, Dražen; Serventi Seiwerth, Ranka; Ilić, Ivana; Grce, Magdalena; Mravak Stipetić, Marinka; Klepac Pulanić, Tajana; Bilić, Ervina; Bilić, Ernest; Milošević, Milan; Vrhovac, Radovan; Nemet, Damir; Pavletic, Steven Z

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Čeović, R., Desnica, L., Pulanić, D., Serventi Seiwerth, R., Ilić, I., Grce, M. ... Pavletic, S. Z. (2016). High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease. Croatian Medical Journal, 57. (3), 229-238. doi: 10.3325/cmj.2016.57.229

Čeović, Romana, et al. "High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease." Croatian Medical Journal, vol. 57, br. 3, 2016, str. 229-238. https://doi.org/10.3325/cmj.2016.57.229

Čeović, Romana, Lana Desnica, Dražen Pulanić, Ranka Serventi Seiwerth, Ivana Ilić, Magdalena Grce, Marinka Mravak Stipetić, et al. "High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease." Croatian Medical Journal 57, br. 3 (2016): 229-238. https://doi.org/10.3325/cmj.2016.57.229

Čeović, R., et al. (2016) 'High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease', Croatian Medical Journal, 57(3), str. 229-238. doi: 10.3325/cmj.2016.57.229

Čeović R, Desnica L, Pulanić D, Serventi Seiwerth R, Ilić I, Grce M, i sur.. High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease. Croatian Medical Journal [Internet]. 06.2016. [pristupljeno 04.05.2024.];57(3):229-238. doi: 10.3325/cmj.2016.57.229

R. Čeović, et al., "High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease", Croatian Medical Journal, vol. 57, br. 3, str. 229-238, Lipanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:491126. [Citirano: 04.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:491126
Podaci o radu
Naslov (engleski)High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease
AutorRomana Čeović
AutorLana Desnica
AutorDražen Pulanić
AutorRanka Serventi Seiwerth
AutorIvana Ilić
AutorMagdalena Grce
AutorMarinka Mravak Stipetić
AutorTajana Klepac Pulanić
AutorErvina Bilić
AutorErnest Bilić
AutorMilan Milošević
AutorRadovan Vrhovac
AutorDamir Nemet
AutorSteven Z Pavletic
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIM: To determine the frequency and the characteristics of cutaneous manifestations, especially vitiligo and alopecia areata, in patients with chronic graft-vs-host disease (cGVHD). ----- METHODS: 50 patients with cGVHD were prospectively enrolled in the observational study protocol and evaluated by an experienced dermatologist. The evaluation was focused on the clinical spectrum of skin and adnexal involvement, and the cutaneous GVHD score was determined according to National Institutes of Health (NIH) Consensus criteria. The presence of vitiligo, alopecia, xerosis, nail changes, and dyspigmentation was also assessed. ----- RESULTS: Out of 50 cGVHD patients, 28 (56%) had skin involvement, and 27 of them (96%) had hypo and/or hyperpigmentations. 11 patients (39%) had a mild cutaneous NIH cGVHD score, 22% moderate, and 39% severe. 15 (30%) patients had nail changes and 10 (20%) had vitiligo or alopecia areata. Univariate analysis showed that patients with vitiligo/alopecia areata received more lines of prior systemic immunosuppressive therapy (P=0.043), had lower Karnofsky performance status (P=0.028), and had a higher B-cell number (P=0.005), platelet count (P=0.022), and total protein (P=0.024). Vitiligo and alopecia areata were associated with higher NIH skin score (P=0.001), higher intensity of immunosuppressive treatment (P=0.020), and total body irradiation conditioning (P=0.040). Multivariate regression model showed that patients with higher NIH skin scoring were 3.67 times more likely to have alopecia and/or vitiligo (odds ratio 3.67; 95% confidence interval 1.26-10.73), controlled for all other factors in the model (age at study entry, number of B-cells, platelet count, and global NIH score). ----- CONCLUSION: These data indicate that vitiligo and alopecia areata occur more frequently in cGVHD than previously reported.
Sažetak (hrvatski)
Visoka učestalost kožnih manifestacija, uključujući vitiligo i alopeciju areatu, u prospektivno prikupljenoj skupini pacijenata s kroničnom bolešću presatka protiv domaćina ----- Cilj: Odrediti učestalost i obilježja kožnih manifestacija, posebice vitiliga i alopecije areate, kod pacijenata s kroničnom bolešću presatka protiv domaćina (prema engl. chronic graft-versus-host disease, cGVHD). ----- Postupci: Opservacijsko istraživanje prospektivno je uključilo 50 pacijenata s cGVHD koje je pregledao iskusni dermatolog. Evaluacija je bila usmjerena na kliničke znakove zahvaćenosti kože i adneksa te je utvrđen kožni GVHD izračun prema kriterijima Nacionalnih instituta za zdravlje SAD-a (prema engl. National Institutes of Health, NIH). Odredili smo prisutnost vitiliga, alopecije, kseroze, promjena noktiju i depigmentacije. ----- Rezultati: Od 50 cGVHD pacijenata, 28 (56%) je imalo zahvaćenu kožu, dok je 27 od njih (96%) imalo hipo i/ili hiperpigmentacije. Prema kožnom NIH cGVHD izračunu, 11 pacijenata (39%) imalo je blagi oblik bolesti, 22% umjereni, a 39% teški oblik bolesti. 15 (30%) pacijenata imalo je promjene noktiju, dok ih je 10 (20%) imalo vitiligo ili alopeciju areatu. Univarijatna analiza pokazala je da su pacijenti s vitiligom/alopecijom areatom primili više linija sustavne imunosupresivne terapije (P=0,043), imali niži Karnofsky izvedbeni status (P=0,028) te veći broj B limfocita (P=0,005), trombocita (P=0,022) i ukupnih proteina (P=0,024). Vitiligo i alopecija areata bili su povezani s višim NIH kožnim izračunom (P=0,001), većim intenzitetom imunosupresivne terapije (P=0,020) i zračenjem cijelog tijela (P=0,040). Multivarijatni regresijski model pokazao je da su pacijenti s višim NIH kožnim izračunom imali 3,67 puta veće izglede da dobiju alopeciju i/ili vitiligo (omjer izgleda 3,67; 95% raspon pouzdanosti 1,26-10,73), uz kontroliranje svih ostalih čimbenika u modelu (dob pri uključenju u istraživanje, broj B stanica, broj krvnih pločica, i ukupni NIH izračun). ----- Zaključak: Naši podaci pokazali su veći broj cGVHD pacijenata s vitiligom i alopecijom nego što je to ranije opaženo.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 57, br. 3, str. 229-238
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2016.57.229
URN:NBNurn:nbn:hr:105:491126
Datum objave publikacije2016-06
URL dokumentahttp://doi.org/10.3325/cmj.2016.57.229
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:43:15