prikaz prve stranice dokumenta Intracranial thrombus morphology and composition undergoes time-dependent changes in acute ischemic stroke: a CT densitometry study
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Scientific paper - Original scientific paper
Intracranial thrombus morphology and composition undergoes time-dependent changes in acute ischemic stroke: a CT densitometry study
International Journal of Molecular Sciences, 17 (2016), 11; E1959. https://doi.org/10.3390/ijms17111959
Pikija, Slaven; Magdič, Jožef; Trkulja, Vladimir; Unterkreuter, Peter; Mutzenbach, Johannes; Novak, Helmut; Weymayr, Friedrich; Hauer, Larissa; Sellner, Johann

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Pikija, S., Magdič, J., Trkulja, V., Unterkreuter, P., Mutzenbach, J., Novak, H. ... Sellner, J. (2016). Intracranial thrombus morphology and composition undergoes time-dependent changes in acute ischemic stroke: a CT densitometry study. International Journal of Molecular Sciences, 17. (11), E1959. doi: 10.3390/ijms17111959

Pikija, Slaven, et al. "Intracranial thrombus morphology and composition undergoes time-dependent changes in acute ischemic stroke: a CT densitometry study." International Journal of Molecular Sciences, vol. 17, no. 11, 2016, p. E1959. https://doi.org/10.3390/ijms17111959

Pikija, Slaven, Jožef Magdič, Vladimir Trkulja, Peter Unterkreuter, Johannes Mutzenbach, Helmut Novak, Friedrich Weymayr, Larissa Hauer and Johann Sellner. "Intracranial thrombus morphology and composition undergoes time-dependent changes in acute ischemic stroke: a CT densitometry study." International Journal of Molecular Sciences 17, no. 11 (2016): E1959. https://doi.org/10.3390/ijms17111959

Pikija, S., et al. (2016) 'Intracranial thrombus morphology and composition undergoes time-dependent changes in acute ischemic stroke: a CT densitometry study', International Journal of Molecular Sciences, 17(11), p. E1959. doi: 10.3390/ijms17111959

Pikija S, Magdič J, Trkulja V, Unterkreuter P, Mutzenbach J, Novak H, and sur.. Intracranial thrombus morphology and composition undergoes time-dependent changes in acute ischemic stroke: a CT densitometry study. International Journal of Molecular Sciences [Internet]. 2016 November 23 [cited 2024 November 26];17(11):E1959. doi: 10.3390/ijms17111959

S. Pikija, et al., "Intracranial thrombus morphology and composition undergoes time-dependent changes in acute ischemic stroke: a CT densitometry study", International Journal of Molecular Sciences, vol. 17, no. 11, p. E1959, November 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:397035. [Accessed: 26 November 2024]

Metadata
Title (english)Intracranial thrombus morphology and composition undergoes time-dependent changes in acute ischemic stroke: a CT densitometry study
AuthorSlaven Pikija
AuthorJožef Magdič
AuthorVladimir Trkulja
AuthorPeter Unterkreuter
AuthorJohannes Mutzenbach
AuthorHelmut Novak
AuthorFriedrich Weymayr
AuthorLarissa Hauer
AuthorJohann Sellner
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aim of our study was to assess whether cerebral artery clots undergo time-dependent morphological and compositional changes in acute ischemic stroke. We performed a retrospective chart review of patients admitted within 5 h from symptom onset to three European stroke centers and evaluated non-contrast-enhanced CT (NECT) for hyperdense artery signs (HAS) in 2565 scans. The occlusion site, density of HAS expressed in Hounsfield units (HU), area of HAS, and relative density (rHU) (HU clot/HU non-affected artery) were studied and related to time from symptom onset, clinical severity, stroke etiology, and laboratory parameters. A HAS was present in the middle cerebral artery (MCA) in 185 (7.2%) and further explored. The mean time from symptom onset to CT was 100 min (range 17-300). We found a time-dependent loss of density in the occluded M1 segment within the first 5 h (N = 118, 95% CI [-15, -2], p = 0.01). Further, the thrombus area in the M2 segment decreased with time (cubic trend N = 67, 95% CI [-63, -8], p = 0.02). Overall, and especially in the M2 segment, a lower clot area was associated with higher fibrinogen (-21.7%, 95% CI [-34.8, -5.8], p = 0.009). In conclusion, our results disclosed time-dependent changes of intracranial thrombi with regard to occlusion site, density and area.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 17, no. 11, p. E1959
p-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms17111959
URN:NBNurn:nbn:hr:105:397035
Publication2016-11-23
Document URLhttps://doi.org/10.3390/ijms17111959
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:11:16