prikaz prve stranice dokumenta Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane
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Scientific paper - Original scientific paper
Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane
Bosnian Journal of Basic Medical Sciences, 17 (2017), 1; 38-46. https://doi.org/10.17305/bjbms.2016.1680
Vrbanović Mijatović, Vilena; Šerman, Ljiljana; Gamulin, Ozren

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Vrbanović Mijatović, V., Šerman, Lj. & Gamulin, O. (2017). Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane. Bosnian Journal of Basic Medical Sciences, 17. (1), 38-46. doi: 10.17305/bjbms.2016.1680

Vrbanović Mijatović, Vilena, et al. "Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane." Bosnian Journal of Basic Medical Sciences, vol. 17, no. 1, 2017, pp. 38-46. https://doi.org/10.17305/bjbms.2016.1680

Vrbanović Mijatović, Vilena, Ljiljana Šerman and Ozren Gamulin. "Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane." Bosnian Journal of Basic Medical Sciences 17, no. 1 (2017): 38-46. https://doi.org/10.17305/bjbms.2016.1680

Vrbanović Mijatović, V., Šerman, Lj. and Gamulin, O. (2017) 'Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane', Bosnian Journal of Basic Medical Sciences, 17(1), pp. 38-46. doi: 10.17305/bjbms.2016.1680

Vrbanović Mijatović V, Šerman Lj, Gamulin O. Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane. Bosnian Journal of Basic Medical Sciences [Internet]. 2017 February 21 [cited 2024 December 24];17(1):38-46. doi: 10.17305/bjbms.2016.1680

V. Vrbanović Mijatović, Lj. Šerman and O. Gamulin, "Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane", Bosnian Journal of Basic Medical Sciences, vol. 17, no. 1, pp. 38-46, February 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:510196. [Accessed: 24 December 2024]

Metadata
Title (english)Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane
AuthorVilena Vrbanović Mijatović
AuthorLjiljana Šerman
AuthorOzren Gamulin
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Pulmonary surfactant, consisting primarily of phospholipids and four surfactant-specific proteins, is among the first structures that is exposed to inhalation anesthetics. Consequently, changes of pulmonary surfactant due to this exposure could cause respiratory complications after long anesthetic procedures. Fourier transform infrared (FTIR) spectroscopy was used to explore the effects of two inhalation anesthetics, sevoflurane and isoflurane, on a commercially available pulmonary surfactant. The research was primarily focused on the effect of anesthetics on the lipid component of the surfactant. Four different concentrations of anesthetics were added, and the doses were higher from the low clinical doses typically used. Recorded spectra were analyzed using principal component analysis, and the Student's t-test was performed to confirm the results. The exposure to both anesthetics induced similar changes, consistent with the increase of the anesthetic concentration. The most pronounced effect was on the hydrophilic head group of phospholipids, which is in agreement with the disruption of the hydrogen bond, caused by the anesthetics. A change in the band intensities of CH2 stretching vibrations, indicative of a disordering effect of anesthetics on the hydrophobic tails of phospholipids, was also observed. Changes induced by isoflurane appear to be more pronounced than those induced by sevoflurane. Furthermore, our results suggest that FTIR spectroscopy is a promising tool in studying anesthetic effects on pulmonary surfactant.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBosnian Journal of Basic Medical Sciences
Numberingvol. 17, no. 1, pp. 38-46
p-ISSN1512-8601
DOIhttps://doi.org/10.17305/bjbms.2016.1680
URN:NBNurn:nbn:hr:105:510196
Publication2017-02-21
Document URLhttps://doi.org/10.17305/bjbms.2016.1680
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:16:13