prikaz prve stranice dokumenta Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane
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Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane
Bosnian Journal of Basic Medical Sciences, 17 (2017), 1; 38-46. https://doi.org/10.17305/bjbms.2016.1680
Vrbanović Mijatović, Vilena; Šerman, Ljiljana; Gamulin, Ozren

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Vrbanović Mijatović, V., Šerman, Lj. i Gamulin, O. (2017). Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane. Bosnian Journal of Basic Medical Sciences, 17. (1), 38-46. doi: 10.17305/bjbms.2016.1680

Vrbanović Mijatović, Vilena, et al. "Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane." Bosnian Journal of Basic Medical Sciences, vol. 17, br. 1, 2017, str. 38-46. https://doi.org/10.17305/bjbms.2016.1680

Vrbanović Mijatović, Vilena, Ljiljana Šerman i Ozren Gamulin. "Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane." Bosnian Journal of Basic Medical Sciences 17, br. 1 (2017): 38-46. https://doi.org/10.17305/bjbms.2016.1680

Vrbanović Mijatović, V., Šerman, Lj. i Gamulin, O. (2017) 'Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane', Bosnian Journal of Basic Medical Sciences, 17(1), str. 38-46. doi: 10.17305/bjbms.2016.1680

Vrbanović Mijatović V, Šerman Lj, Gamulin O. Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane. Bosnian Journal of Basic Medical Sciences [Internet]. 21.02.2017. [pristupljeno 29.04.2024.];17(1):38-46. doi: 10.17305/bjbms.2016.1680

V. Vrbanović Mijatović, Lj. Šerman i O. Gamulin, "Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane", Bosnian Journal of Basic Medical Sciences, vol. 17, br. 1, str. 38-46, Veljača 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:510196. [Citirano: 29.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:510196
Podaci o radu
Naslov (engleski)Analysis of pulmonary surfactant by Fourier transform infrared spectroscopy after exposure to sevoflurane and isoflurane
AutorVilena Vrbanović Mijatović
AutorLjiljana Šerman
AutorOzren Gamulin
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Pulmonary surfactant, consisting primarily of phospholipids and four surfactant-specific proteins, is among the first structures that is exposed to inhalation anesthetics. Consequently, changes of pulmonary surfactant due to this exposure could cause respiratory complications after long anesthetic procedures. Fourier transform infrared (FTIR) spectroscopy was used to explore the effects of two inhalation anesthetics, sevoflurane and isoflurane, on a commercially available pulmonary surfactant. The research was primarily focused on the effect of anesthetics on the lipid component of the surfactant. Four different concentrations of anesthetics were added, and the doses were higher from the low clinical doses typically used. Recorded spectra were analyzed using principal component analysis, and the Student's t-test was performed to confirm the results. The exposure to both anesthetics induced similar changes, consistent with the increase of the anesthetic concentration. The most pronounced effect was on the hydrophilic head group of phospholipids, which is in agreement with the disruption of the hydrogen bond, caused by the anesthetics. A change in the band intensities of CH2 stretching vibrations, indicative of a disordering effect of anesthetics on the hydrophobic tails of phospholipids, was also observed. Changes induced by isoflurane appear to be more pronounced than those induced by sevoflurane. Furthermore, our results suggest that FTIR spectroscopy is a promising tool in studying anesthetic effects on pulmonary surfactant.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBosnian Journal of Basic Medical Sciences
Brojčani podacivol. 17, br. 1, str. 38-46
p-ISSN1512-8601
DOIhttps://doi.org/10.17305/bjbms.2016.1680
URN:NBNurn:nbn:hr:105:510196
Datum objave publikacije2017-02-21
URL dokumentahttps://doi.org/10.17305/bjbms.2016.1680
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 09:16:13