prikaz prve stranice dokumenta Hypopituitarism after gamma knife radiosurgery for pituitary adenoma
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Scientific paper - Original scientific paper
Hypopituitarism after gamma knife radiosurgery for pituitary adenoma
Endocrine Research, 42 (2017), 4; 318-324. https://doi.org/10.1080/07435800.2017.1323913
Zibar Tomšić, Karin; Dušek, Tina; Kraljević, Ivana; Heinrich, Zdravko; Solak, Mirsala; Vučinović, Ana; Ozretić, David; Mihailović Marasanov, Sergej; Hršak, Hrvoje; Kaštelan, Darko

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Zibar Tomšić, K., Dušek, T., Kraljević, I., Heinrich, Z., Solak, M., Vučinović, A. ... Kaštelan, D. (2017). Hypopituitarism after gamma knife radiosurgery for pituitary adenoma. Endocrine Research, 42. (4), 318-324. doi: 10.1080/07435800.2017.1323913

Zibar Tomšić, Karin, et al. "Hypopituitarism after gamma knife radiosurgery for pituitary adenoma." Endocrine Research, vol. 42, no. 4, 2017, pp. 318-324. https://doi.org/10.1080/07435800.2017.1323913

Zibar Tomšić, Karin, Tina Dušek, Ivana Kraljević, Zdravko Heinrich, Mirsala Solak, Ana Vučinović, David Ozretić, Sergej Mihailović Marasanov, Hrvoje Hršak and Darko Kaštelan. "Hypopituitarism after gamma knife radiosurgery for pituitary adenoma." Endocrine Research 42, no. 4 (2017): 318-324. https://doi.org/10.1080/07435800.2017.1323913

Zibar Tomšić, K., et al. (2017) 'Hypopituitarism after gamma knife radiosurgery for pituitary adenoma', Endocrine Research, 42(4), pp. 318-324. doi: 10.1080/07435800.2017.1323913

Zibar Tomšić K, Dušek T, Kraljević I, Heinrich Z, Solak M, Vučinović A, and sur.. Hypopituitarism after gamma knife radiosurgery for pituitary adenoma. Endocrine Research [Internet]. 2017 November [cited 2025 April 03];42(4):318-324. doi: 10.1080/07435800.2017.1323913

K. Zibar Tomšić, et al., "Hypopituitarism after gamma knife radiosurgery for pituitary adenoma", Endocrine Research, vol. 42, no. 4, pp. 318-324, November 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:695091. [Accessed: 03 April 2025]

Metadata
Title (english)Hypopituitarism after gamma knife radiosurgery for pituitary adenoma
AuthorKarin Zibar Tomšić
AuthorTina Dušek
AuthorIvana Kraljević
AuthorZdravko Heinrich
AuthorMirsala Solak
AuthorAna Vučinović
AuthorDavid Ozretić
AuthorSergej Mihailović Marasanov
AuthorHrvoje Hršak
AuthorDarko Kaštelan
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
PURPOSE: The aim of the study was to investigate the incidence of and risk factors for hypopituitarism after gamma knife radiosurgery (GKRS) for pituitary adenoma. ----- MATERIALS AND METHODS: We conducted a retrospective analysis of the pituitary function of 90 patients who underwent GKRS for pituitary adenoma at the University Hospital Centre Zagreb between 2003 and 2014. Twenty seven of them met the inclusion criteria and the others were excluded from the study due to pituitary... More insufficiency which was present before GKRS. Eighteen patients had non-functioning and 9 patients had secretory adenomas. Median patients' age was 56 years (24-82). GKRS was performed using the Leksell gamma knife Model C. The median prescription radiation dose was 20 Gy (15-25) and the median tumor volume size was 3.4 cm3 (0.06-16.81). New onset hypopituitarism was defined as a new deficit of one of the three hormonal axes (corticotroph, thyreotroph, or gonadotroph) ≥3 months following GKRS. SPSS was used for statistical analysis, with the significance level at P<0.05. ----- RESULTS: During the median follow-up period of 72 months (range 6-144), 30% of patients developed new hypopituitarism after GKRS. This corresponds to incidence of one new case of hypopituitarism per 15 patient-years. Age, gender, tumor function, tumor volume, suprasellar extension, prescription dose of radiation, as well as dose-volume to the pituitary gland, stalk and hypothalamus were not predictive factors for the development of hypopituitarism. ----- CONCLUSIONS: In our cohort of patients with pituitary tumors who underwent GKRS, 30% developed new hypopituitarism during the follow-up period. Less
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleEndocrine Research
Numberingvol. 42, no. 4, pp. 318-324
p-ISSN0743-5800
DOIhttps://doi.org/10.1080/07435800.2017.1323913
URN:NBNurn:nbn:hr:105:695091
Publication2017-11
Document URLhttp://doi.org/10.1080/07435800.2017.1323913
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:20:26
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