prikaz prve stranice dokumenta Hypopituitarism after gamma knife radiosurgery for pituitary adenoma
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Hypopituitarism after gamma knife radiosurgery for pituitary adenoma
Endocrine Research, 42 (2017), 4; 318-324. https://doi.org/10.1080/07435800.2017.1323913
Zibar Tomšić, Karin; Dušek, Tina; Kraljević, Ivana; Heinrich, Zdravko; Solak, Mirsala; Vučinović, Ana; Ozretić, David; Mihailović Marasanov, Sergej; Hršak, Hrvoje; Kaštelan, Darko

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Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Zibar Tomšić, K., Dušek, T., Kraljević, I., Heinrich, Z., Solak, M., Vučinović, A. ... Kaštelan, D. (2017). Hypopituitarism after gamma knife radiosurgery for pituitary adenoma. Endocrine Research, 42. (4), 318-324. doi: 10.1080/07435800.2017.1323913

Zibar Tomšić, Karin, et al. "Hypopituitarism after gamma knife radiosurgery for pituitary adenoma." Endocrine Research, vol. 42, br. 4, 2017, str. 318-324. https://doi.org/10.1080/07435800.2017.1323913

Zibar Tomšić, Karin, Tina Dušek, Ivana Kraljević, Zdravko Heinrich, Mirsala Solak, Ana Vučinović, David Ozretić, Sergej Mihailović Marasanov, Hrvoje Hršak i Darko Kaštelan. "Hypopituitarism after gamma knife radiosurgery for pituitary adenoma." Endocrine Research 42, br. 4 (2017): 318-324. https://doi.org/10.1080/07435800.2017.1323913

Zibar Tomšić, K., et al. (2017) 'Hypopituitarism after gamma knife radiosurgery for pituitary adenoma', Endocrine Research, 42(4), str. 318-324. doi: 10.1080/07435800.2017.1323913

Zibar Tomšić K, Dušek T, Kraljević I, Heinrich Z, Solak M, Vučinović A, i sur.. Hypopituitarism after gamma knife radiosurgery for pituitary adenoma. Endocrine Research [Internet]. 11.2017. [pristupljeno 28.03.2025.];42(4):318-324. doi: 10.1080/07435800.2017.1323913

K. Zibar Tomšić, et al., "Hypopituitarism after gamma knife radiosurgery for pituitary adenoma", Endocrine Research, vol. 42, br. 4, str. 318-324, Studeni 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:695091. [Citirano: 28.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:695091
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Naslov (engleski)Hypopituitarism after gamma knife radiosurgery for pituitary adenoma
AutorKarin Zibar Tomšić
AutorTina Dušek
AutorIvana Kraljević
AutorZdravko Heinrich
AutorMirsala Solak
AutorAna Vučinović
AutorDavid Ozretić
AutorSergej Mihailović Marasanov
AutorHrvoje Hršak
AutorDarko Kaštelan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
PURPOSE: The aim of the study was to investigate the incidence of and risk factors for hypopituitarism after gamma knife radiosurgery (GKRS) for pituitary adenoma. ----- MATERIALS AND METHODS: We conducted a retrospective analysis of the pituitary function of 90 patients who underwent GKRS for pituitary adenoma at the University Hospital Centre Zagreb between 2003 and 2014. Twenty seven of them met the inclusion criteria and the others were excluded from the study due to pituitary... Više insufficiency which was present before GKRS. Eighteen patients had non-functioning and 9 patients had secretory adenomas. Median patients' age was 56 years (24-82). GKRS was performed using the Leksell gamma knife Model C. The median prescription radiation dose was 20 Gy (15-25) and the median tumor volume size was 3.4 cm3 (0.06-16.81). New onset hypopituitarism was defined as a new deficit of one of the three hormonal axes (corticotroph, thyreotroph, or gonadotroph) ≥3 months following GKRS. SPSS was used for statistical analysis, with the significance level at P<0.05. ----- RESULTS: During the median follow-up period of 72 months (range 6-144), 30% of patients developed new hypopituitarism after GKRS. This corresponds to incidence of one new case of hypopituitarism per 15 patient-years. Age, gender, tumor function, tumor volume, suprasellar extension, prescription dose of radiation, as well as dose-volume to the pituitary gland, stalk and hypothalamus were not predictive factors for the development of hypopituitarism. ----- CONCLUSIONS: In our cohort of patients with pituitary tumors who underwent GKRS, 30% developed new hypopituitarism during the follow-up period. Sakrij dio sažetka
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaEndocrine Research
Brojčani podacivol. 42, br. 4, str. 318-324
p-ISSN0743-5800
DOIhttps://doi.org/10.1080/07435800.2017.1323913
URN:NBNurn:nbn:hr:105:695091
Datum objave publikacije2017-11
URL dokumentahttp://doi.org/10.1080/07435800.2017.1323913
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 09:20:26
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