prikaz prve stranice dokumenta Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development
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Scientific paper - Original scientific paper
Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development
Croatian Medical Journal, 59 (2018), 5; 189-202. https://doi.org/10.3325/cmj.2018.59.189
Sedmak, Dora; Hrvoj-Mihić, Branka; Džaja, Domagoj; Habek, Nikola; Uylings, Harry B. M.; Petanjek, Zdravko

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Sedmak, D., Hrvoj Mihić, B., Džaja, D., Habek, N., Uylings, H. B. M. & Petanjek, Z. (2018). Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development. Croatian Medical Journal, 59. (5), 189-202. doi: 10.3325/cmj.2018.59.189

Sedmak, Dora, et al. "Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development." Croatian Medical Journal, vol. 59, no. 5, 2018, pp. 189-202. https://doi.org/10.3325/cmj.2018.59.189

Sedmak, Dora, Branka Hrvoj Mihić, Domagoj Džaja, Nikola Habek, Harry B. M. Uylings and Zdravko Petanjek. "Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development." Croatian Medical Journal 59, no. 5 (2018): 189-202. https://doi.org/10.3325/cmj.2018.59.189

Sedmak, D., et al. (2018) 'Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development', Croatian Medical Journal, 59(5), pp. 189-202. doi: 10.3325/cmj.2018.59.189

Sedmak D, Hrvoj Mihić B, Džaja D, Habek N, Uylings HBM, Petanjek Z. Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development. Croatian Medical Journal [Internet]. 2018 October 31 [cited 2024 November 30];59(5):189-202. doi: 10.3325/cmj.2018.59.189

D. Sedmak, B. Hrvoj Mihić, D. Džaja, N. Habek, H. B. M. Uylings and Z. Petanjek, "Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development", Croatian Medical Journal, vol. 59, no. 5, pp. 189-202, October 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:882818. [Accessed: 30 November 2024]

Metadata
Title (croatian)Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development
AuthorDora Sedmak
AuthorBranka Hrvoj-Mihić
AuthorDomagoj Džaja
AuthorNikola Habek
AuthorHarry B. M. Uylings
AuthorZdravko Petanjek
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Aim: To analyze postnatal development and life-span changes of apical dendrite side branches (oblique dendrites) from associative layer IIIC magnopyramidal neurons in the human dorsolateral prefrontal cortex and to compare the findings with the previously established pattern of basal dendrite development. Methods: We analyzed dendritic morphology from 352 rapid-Golgi impregnated neurons (10-18 neurons per subject) in Brodmann area 9 from the post-mortem tissue of 25 subjects ranging in age from 1 week to 91 years. Data were collected in the period between 1994 and 1996, and the analysis was performed between September 2017 and February 2018. Quantitative dendritic parameters were statistically analyzed using one-way analysis of variance and two-tailed t tests. Results: Oblique dendrites grew rapidly during the first postnatal months, and the increase in the dendrite length was accompanied by the outgrowth of new dendritic segments. After a more than one-year-long “dormant” period of only fine dendritic rearrangements (2.5-16 months), oblique dendrites displayed a second period of marked growth, continuing through the third postnatal year. Basal and oblique dendrites displayed roughly the same growth pattern, but had considerably different topological organization in adulthood. Conclusion: Our analysis confirmed that a biphasic pattern of postnatal dendritic development, together with a second growth spurt at the age of 2-3 years, represents a unique feature of the associative layer IIIC magnopyramidal neurons in the human dorsolateral prefrontal cortex. We propose that these structural changes relate to rapid cognitive development during early childhood.
Keywords (english)
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 59, no. 5, pp. 189-202
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2018.59.189
URN:NBNurn:nbn:hr:105:882818
Publication2018-10-31
Document URLhttp://doi.org/10.3325/cmj.2018.59.189
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:48:18