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Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development
Croatian Medical Journal, 59 (2018), 5; 189-202. https://doi.org/10.3325/cmj.2018.59.189
Sedmak, Dora; Hrvoj-Mihić, Branka; Džaja, Domagoj; Habek, Nikola; Uylings, Harry B. M.; Petanjek, Zdravko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Sedmak, D., Hrvoj Mihić, B., Džaja, D., Habek, N., Uylings, H. B. M. i Petanjek, Z. (2018). Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development. Croatian Medical Journal, 59. (5), 189-202. doi: 10.3325/cmj.2018.59.189

Sedmak, Dora, et al. "Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development." Croatian Medical Journal, vol. 59, br. 5, 2018, str. 189-202. https://doi.org/10.3325/cmj.2018.59.189

Sedmak, Dora, Branka Hrvoj Mihić, Domagoj Džaja, Nikola Habek, Harry B. M. Uylings i Zdravko Petanjek. "Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development." Croatian Medical Journal 59, br. 5 (2018): 189-202. https://doi.org/10.3325/cmj.2018.59.189

Sedmak, D., et al. (2018) 'Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development', Croatian Medical Journal, 59(5), str. 189-202. doi: 10.3325/cmj.2018.59.189

Sedmak D, Hrvoj Mihić B, Džaja D, Habek N, Uylings HBM, Petanjek Z. Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development. Croatian Medical Journal [Internet]. 31.10.2018. [pristupljeno 26.11.2024.];59(5):189-202. doi: 10.3325/cmj.2018.59.189

D. Sedmak, B. Hrvoj Mihić, D. Džaja, N. Habek, H. B. M. Uylings i Z. Petanjek, "Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development", Croatian Medical Journal, vol. 59, br. 5, str. 189-202, Listopad 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:882818. [Citirano: 26.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:882818
Podaci o radu
Naslov (hrvatski)Biphasic dendritic growth of dorsolateral prefrontal cortex associative neurons and early cognitive development
AutorDora Sedmak
AutorBranka Hrvoj-Mihić
AutorDomagoj Džaja
AutorNikola Habek
AutorHarry B. M. Uylings
AutorZdravko Petanjek
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Aim: To analyze postnatal development and life-span changes of apical dendrite side branches (oblique dendrites) from associative layer IIIC magnopyramidal neurons in the human dorsolateral prefrontal cortex and to compare the findings with the previously established pattern of basal dendrite development. Methods: We analyzed dendritic morphology from 352 rapid-Golgi impregnated neurons (10-18 neurons per subject) in Brodmann area 9 from the post-mortem tissue of 25 subjects ranging in age from 1 week to 91 years. Data were collected in the period between 1994 and 1996, and the analysis was performed between September 2017 and February 2018. Quantitative dendritic parameters were statistically analyzed using one-way analysis of variance and two-tailed t tests. Results: Oblique dendrites grew rapidly during the first postnatal months, and the increase in the dendrite length was accompanied by the outgrowth of new dendritic segments. After a more than one-year-long “dormant” period of only fine dendritic rearrangements (2.5-16 months), oblique dendrites displayed a second period of marked growth, continuing through the third postnatal year. Basal and oblique dendrites displayed roughly the same growth pattern, but had considerably different topological organization in adulthood. Conclusion: Our analysis confirmed that a biphasic pattern of postnatal dendritic development, together with a second growth spurt at the age of 2-3 years, represents a unique feature of the associative layer IIIC magnopyramidal neurons in the human dorsolateral prefrontal cortex. We propose that these structural changes relate to rapid cognitive development during early childhood.
Ključne riječi (engleski)
Jezikhrvatski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 59, br. 5, str. 189-202
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2018.59.189
URN:NBNurn:nbn:hr:105:882818
Datum objave publikacije2018-10-31
URL dokumentahttp://doi.org/10.3325/cmj.2018.59.189
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:48:18