prikaz prve stranice dokumenta A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion
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Scientific paper - Case study
A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion
Medicine, 96 (2017), 52; e9075. https://doi.org/10.1097/MD.0000000000009075
Zupančić-Šalek, Silva; Vodanović, Marijo; Pulanić, Dražen; Skorić, Boško; Matytsina, Irina; Klovaite, Jolanta

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Zupančić Šalek, S., Vodanović, M., Pulanić, D., Skorić, B., Matytsina, I. & Klovaite, J. (2017). A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion. Medicine, 96. (52). doi: 10.1097/MD.0000000000009075

Zupančić Šalek, Silva, et al. "A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion." Medicine, vol. 96, no. 52, 2017. https://doi.org/10.1097/MD.0000000000009075

Zupančić Šalek, Silva, Marijo Vodanović, Dražen Pulanić, Boško Skorić, Irina Matytsina and Jolanta Klovaite. "A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion." Medicine 96, no. 52 (2017). https://doi.org/10.1097/MD.0000000000009075

Zupančić Šalek, S., et al. (2017) 'A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion', Medicine, 96(52). doi: 10.1097/MD.0000000000009075

Zupančić Šalek S, Vodanović M, Pulanić D, Skorić B, Matytsina I, Klovaite J. A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion. Medicine [Internet]. 2017 December [cited 2024 May 07];96(52). doi: 10.1097/MD.0000000000009075

S. Zupančić Šalek, M. Vodanović, D. Pulanić, B. Skorić, I. Matytsina and J. Klovaite, "A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion", Medicine, vol. 96, no. 52, December 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:238717. [Accessed: 07 May 2024]

Metadata
Title (english)A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion
AuthorSilva Zupančić-Šalek
AuthorMarijo Vodanović
AuthorDražen Pulanić
AuthorBoško Skorić
AuthorIrina Matytsina
AuthorJolanta Klovaite
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
RATIONALE: The extent of protective effects of hemophilia against thrombotic events such as myocardial infarction (MI) and other acute coronary syndromes remains to be determined, as major risk factors for cardiovascular disease exist despite factor VIII (FVIII) deficiency. We present a case report of a 41-year-old male with severe hemophilia A and several cardiovascular risk factors. ----- PATIENT CONCERNS: This morbidly obese patient developed chest pressure, followed by chest pain and difficulty in breathing shortly after receiving on-demand treatment with intravenous recombinant FVIII (rFVIII) (turoctocog alfa) dosed per body weight. ----- DIAGNOSES: An electrocardiogram revealed a diagnosis of inferior ST-segment elevation MI. ----- INTERVENTIONS: The patient underwent an urgent coronary angiography using a radial artery approach. During the next 12 months, he received dual antiplatelet treatment, acetylsalicylic acid 100 mg, and clopidogrel 75 mg daily. His treatment for severe hemophilia A was changed to plasma-derived FVIII replacement therapy. -----OUTCOMES: During this 12-month period, he experienced several small bleeds in his elbows. ----- CONCLUSIONS: The temporal relationship between rFVIII infusion and onset of the MI suggests a possible association; however, apart from obesity, the patient also had other major risk factors for arterial thrombosis, such as hypertension and smoking. Furthermore, atherosclerotic disease and underlying atherosclerotic changes could not be excluded with certainty. This case highlights the importance of studies assessing the impact of excess body weight on rFVIII dosing.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicine
Numberingvol. 96, no. 52, e9075
p-ISSN0025-7974
DOIhttps://doi.org/10.1097/MD.0000000000009075
URN:NBNurn:nbn:hr:105:238717
Publication2017-12
Document URLhttps://doi.org/10.1097/MD.0000000000009075
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:53:32