prikaz prve stranice dokumenta A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion
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A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion
Medicine, 96 (2017), 52; e9075. https://doi.org/10.1097/MD.0000000000009075
Zupančić-Šalek, Silva; Vodanović, Marijo; Pulanić, Dražen; Skorić, Boško; Matytsina, Irina; Klovaite, Jolanta

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Zupančić Šalek, S., Vodanović, M., Pulanić, D., Skorić, B., Matytsina, I. i Klovaite, J. (2017). A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion. Medicine, 96. (52). doi: 10.1097/MD.0000000000009075

Zupančić Šalek, Silva, et al. "A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion." Medicine, vol. 96, br. 52, 2017. https://doi.org/10.1097/MD.0000000000009075

Zupančić Šalek, Silva, Marijo Vodanović, Dražen Pulanić, Boško Skorić, Irina Matytsina i Jolanta Klovaite. "A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion." Medicine 96, br. 52 (2017). https://doi.org/10.1097/MD.0000000000009075

Zupančić Šalek, S., et al. (2017) 'A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion', Medicine, 96(52). doi: 10.1097/MD.0000000000009075

Zupančić Šalek S, Vodanović M, Pulanić D, Skorić B, Matytsina I, Klovaite J. A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion. Medicine [Internet]. 12.2017. [pristupljeno 10.05.2024.];96(52). doi: 10.1097/MD.0000000000009075

S. Zupančić Šalek, M. Vodanović, D. Pulanić, B. Skorić, I. Matytsina i J. Klovaite, "A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion", Medicine, vol. 96, br. 52, Prosinac 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:238717. [Citirano: 10.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:238717
Podaci o radu
Naslov (engleski)A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion
AutorSilva Zupančić-Šalek
AutorMarijo Vodanović
AutorDražen Pulanić
AutorBoško Skorić
AutorIrina Matytsina
AutorJolanta Klovaite
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
RATIONALE: The extent of protective effects of hemophilia against thrombotic events such as myocardial infarction (MI) and other acute coronary syndromes remains to be determined, as major risk factors for cardiovascular disease exist despite factor VIII (FVIII) deficiency. We present a case report of a 41-year-old male with severe hemophilia A and several cardiovascular risk factors. ----- PATIENT CONCERNS: This morbidly obese patient developed chest pressure, followed by chest pain and difficulty in breathing shortly after receiving on-demand treatment with intravenous recombinant FVIII (rFVIII) (turoctocog alfa) dosed per body weight. ----- DIAGNOSES: An electrocardiogram revealed a diagnosis of inferior ST-segment elevation MI. ----- INTERVENTIONS: The patient underwent an urgent coronary angiography using a radial artery approach. During the next 12 months, he received dual antiplatelet treatment, acetylsalicylic acid 100 mg, and clopidogrel 75 mg daily. His treatment for severe hemophilia A was changed to plasma-derived FVIII replacement therapy. -----OUTCOMES: During this 12-month period, he experienced several small bleeds in his elbows. ----- CONCLUSIONS: The temporal relationship between rFVIII infusion and onset of the MI suggests a possible association; however, apart from obesity, the patient also had other major risk factors for arterial thrombosis, such as hypertension and smoking. Furthermore, atherosclerotic disease and underlying atherosclerotic changes could not be excluded with certainty. This case highlights the importance of studies assessing the impact of excess body weight on rFVIII dosing.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prikaz slučaja
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedicine
Brojčani podacivol. 96, br. 52, e9075
p-ISSN0025-7974
DOIhttps://doi.org/10.1097/MD.0000000000009075
URN:NBNurn:nbn:hr:105:238717
Datum objave publikacije2017-12
URL dokumentahttps://doi.org/10.1097/MD.0000000000009075
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 09:53:32