prikaz prve stranice dokumenta Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights
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Scientific paper - Original scientific paper
Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights
World Journal of Gastroenterology, 23 (2017), 48; 8465-8488. https://doi.org/10.3748/wjg.v23.i48.8465
Duzel, Antonija; Vlainić, Josipa; Antunović, Marko; Malekinušić, Dominik; Vrdoljak, Borna; Samara, Mariam; Gojković, Slaven; Krežić, Ivan; Vidović, Tinka; Bilić, Zdenko; Knežević, Mario; Sever, Marko; Lojo, Nermin; Kokot, Antonio; Kolovrat, Marijan; Drmić, Domagoj; Vukojević, Jakša; Kralj, Tamara; Kasnik, Katarina; Siroglavić, Marko; Seiwerth, Sven; Sikirić, Predrag More authors...

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Duzel, A., Vlainić, J., Antunović, M., Malekinušić, D., Vrdoljak, B., Samara, M. ... Sikirić, P. (2017). Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights. World Journal of Gastroenterology, 23. (48), 8465-8488. doi: 10.3748/wjg.v23.i48.8465

Duzel, Antonija, et al. "Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights." World Journal of Gastroenterology, vol. 23, no. 48, 2017, pp. 8465-8488. https://doi.org/10.3748/wjg.v23.i48.8465

Duzel, Antonija, Josipa Vlainić, Marko Antunović, Dominik Malekinušić, Borna Vrdoljak, Mariam Samara, Slaven Gojković, et al. "Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights." World Journal of Gastroenterology 23, no. 48 (2017): 8465-8488. https://doi.org/10.3748/wjg.v23.i48.8465

Duzel, A., et al. (2017) 'Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights', World Journal of Gastroenterology, 23(48), pp. 8465-8488. doi: 10.3748/wjg.v23.i48.8465

Duzel A, Vlainić J, Antunović M, Malekinušić D, Vrdoljak B, Samara M, and sur.. Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights. World Journal of Gastroenterology [Internet]. 2017 December 30 [cited 2024 November 05];23(48):8465-8488. doi: 10.3748/wjg.v23.i48.8465

A. Duzel, et al., "Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights", World Journal of Gastroenterology, vol. 23, no. 48, pp. 8465-8488, December 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:507724. [Accessed: 05 November 2024]

Metadata
Title (english)Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights
AuthorAntonija Duzel
AuthorJosipa Vlainić
AuthorMarko Antunović
AuthorDominik Malekinušić
AuthorBorna Vrdoljak
AuthorMariam Samara
AuthorSlaven Gojković
AuthorIvan Krežić
AuthorTinka Vidović
AuthorZdenko Bilić
AuthorMario Knežević
AuthorMarko Sever
AuthorNermin Lojo
AuthorAntonio Kokot
AuthorMarijan Kolovrat
AuthorDomagoj Drmić
AuthorJakša Vukojević
AuthorTamara Kralj
AuthorKatarina Kasnik
AuthorMarko Siroglavić
AuthorSven Seiwerth
AuthorPredrag Sikirić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157. ----- METHODS: Medication [BPC 157, L-NAME, L-arginine (alone/combined), saline] was bath at the blood deprived colon segment. During reperfusion, medication was BPC 157 or saline. We recorded (USB microscope camera) vessel presentation through next 15 min of ischemic colitis (IC-rats) or reperfusion (removed ligations) (IC + RL-rats); oxidative stress as MDA (increased (IC- and IC + RL-rats)) and NO levels (decreased (IC-rats); increased (IC + RL-rats)) in colon tissue. IC + OB-rats [IC-rats had additional colon obstruction (OB)] for 3 d (IC + OB-rats), then received BPC 157 bath. ----- RESULTS: Commonly, in colon segment (25 mm, 2 ligations on left colic artery and vein, 3 arcade vessels within ligated segment), in IC-, IC + RL-, IC + OB-rats, BPC 157 (10 μg/kg) bath (1 mL/rat) increased vessel presentation, inside/outside arcade interconnections quickly reappeared, mucosal folds were preserved and the pale areas were small and markedly reduced. BPC 157 counteracted worsening effects induced by L-NAME (5 mg) and L-arginine (100 mg). MDA- and NO-levels were normal in BPC 157 treated IC-rats and IC + RL-rats. In addition, on day 10, BPC 157-treated IC + OB-rats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects; the treated colon segment was of normal diameter, and only small adhesions were present. ----- CONCLUSION: BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleWorld Journal of Gastroenterology
Numberingvol. 23, no. 48, pp. 8465-8488
p-ISSN1007-9327
DOIhttps://doi.org/10.3748/wjg.v23.i48.8465
URN:NBNurn:nbn:hr:105:507724
Publication2017-12-30
Document URLhttp://doi.org/10.3748/wjg.v23.i48.8465
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:00:16