prikaz prve stranice dokumenta Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights
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Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights
World Journal of Gastroenterology, 23 (2017), 48; 8465-8488. https://doi.org/10.3748/wjg.v23.i48.8465
Duzel, Antonija; Vlainić, Josipa; Antunović, Marko; Malekinušić, Dominik; Vrdoljak, Borna; Samara, Mariam; Gojković, Slaven; Krežić, Ivan; Vidović, Tinka; Bilić, Zdenko; Knežević, Mario; Sever, Marko; Lojo, Nermin; Kokot, Antonio; Kolovrat, Marijan; Drmić, Domagoj; Vukojević, Jakša; Kralj, Tamara; Kasnik, Katarina; Siroglavić, Marko; Seiwerth, Sven; Sikirić, Predrag Više autora...

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Duzel, A., Vlainić, J., Antunović, M., Malekinušić, D., Vrdoljak, B., Samara, M. ... Sikirić, P. (2017). Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights. World Journal of Gastroenterology, 23. (48), 8465-8488. doi: 10.3748/wjg.v23.i48.8465

Duzel, Antonija, et al. "Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights." World Journal of Gastroenterology, vol. 23, br. 48, 2017, str. 8465-8488. https://doi.org/10.3748/wjg.v23.i48.8465

Duzel, Antonija, Josipa Vlainić, Marko Antunović, Dominik Malekinušić, Borna Vrdoljak, Mariam Samara, Slaven Gojković, et al. "Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights." World Journal of Gastroenterology 23, br. 48 (2017): 8465-8488. https://doi.org/10.3748/wjg.v23.i48.8465

Duzel, A., et al. (2017) 'Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights', World Journal of Gastroenterology, 23(48), str. 8465-8488. doi: 10.3748/wjg.v23.i48.8465

Duzel A, Vlainić J, Antunović M, Malekinušić D, Vrdoljak B, Samara M, i sur.. Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights. World Journal of Gastroenterology [Internet]. 30.12.2017. [pristupljeno 24.12.2024.];23(48):8465-8488. doi: 10.3748/wjg.v23.i48.8465

A. Duzel, et al., "Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights", World Journal of Gastroenterology, vol. 23, br. 48, str. 8465-8488, Prosinac 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:507724. [Citirano: 24.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:507724
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Naslov (engleski)Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights
AutorAntonija Duzel
AutorJosipa Vlainić
AutorMarko Antunović
AutorDominik Malekinušić
AutorBorna Vrdoljak
AutorMariam Samara
AutorSlaven Gojković
AutorIvan Krežić
AutorTinka Vidović
AutorZdenko Bilić
AutorMario Knežević
AutorMarko Sever
AutorNermin Lojo
AutorAntonio Kokot
AutorMarijan Kolovrat
AutorDomagoj Drmić
AutorJakša Vukojević
AutorTamara Kralj
AutorKatarina Kasnik
AutorMarko Siroglavić
AutorSven Seiwerth
AutorPredrag Sikirić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIM: To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157. ----- METHODS: Medication [BPC 157, L-NAME, L-arginine (alone/combined), saline] was bath at the blood deprived colon segment. During reperfusion, medication was BPC 157 or saline. We recorded (USB microscope camera) vessel presentation through next 15 min of ischemic colitis (IC-rats) or reperfusion (removed ligations) (IC + RL-rats); oxidative stress as MDA (increased (IC- and IC + RL-rats)) and NO levels (decreased (IC-rats); increased (IC + RL-rats)) in colon tissue. IC + OB-rats [IC-rats had additional colon obstruction (OB)] for 3 d (IC + OB-rats), then received BPC 157 bath. ----- RESULTS: Commonly, in colon segment (25 mm, 2 ligations on left colic artery and vein, 3 arcade vessels within ligated segment), in IC-, IC + RL-, IC + OB-rats, BPC 157 (10 μg/kg) bath (1 mL/rat) increased vessel presentation, inside/outside arcade interconnections quickly reappeared, mucosal folds were preserved and the pale areas were small and markedly reduced. BPC 157 counteracted worsening effects induced by L-NAME (5 mg) and L-arginine (100 mg). MDA- and NO-levels were normal in BPC 157 treated IC-rats and IC + RL-rats. In addition, on day 10, BPC 157-treated IC + OB-rats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects; the treated colon segment was of normal diameter, and only small adhesions were present. ----- CONCLUSION: BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaWorld Journal of Gastroenterology
Brojčani podacivol. 23, br. 48, str. 8465-8488
p-ISSN1007-9327
DOIhttps://doi.org/10.3748/wjg.v23.i48.8465
URN:NBNurn:nbn:hr:105:507724
Datum objave publikacije2017-12-30
URL dokumentahttp://doi.org/10.3748/wjg.v23.i48.8465
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:00:16