Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Dadaev, Tokhir; Saunders, Edward J.; Newcombe, Paul J.; Anokian, Ezequiel; Leongamornlert, Daniel A.; Brook, Mark N.; Cieza-Borrella, Clara; Mijuskovic, Martina; Wakerell, Sarah; Olama, Ali Amin Al; Schumacher, Fredrick R.; Berndt, Sonja I.; Benlloch, Sara; Ahmed, Mahbubl; Goh, Chee; Sheng, Xin; Zhang, Zhuo; Muir, Kenneth; Govindasami, Koveela; Lophatananon, Artitaya; Stevens, Victoria L.; Gapstur, Susan M.; Carter, Brian D.; Tangen, Catherine M.; Goodman, Phyllis; Thompson, Ian M.; Batra, Jyotsna; Chambers, Suzanne; Moya, Leire; Clements, Judith; Horvath, Lisa; Tilley, Wayne; Risbridger, Gail; Gronberg, Henrik; Aly, Markus; Nordström, Tobias; Pharoah, Paul; Pashayan, Nora; Schleutker, Johanna; Tammela, Teuvo L. J.; Sipeky, Csilla; Auvinen, Anssi; Albanes, Demetrius; Weinstein, Stephanie; Wolk, Alicja; Hakansson, Niclas; West, Catharine; Dunning, Alison M.; Burnet, Neil; Mucci, Lorelei; Giovannucci, Edward; Andriole, Gerald; Cussenot, Olivier; Cancel-Tassin, Géraldine; Koutros, Stella; Freeman, Laura E. Beane; Sorensen, Karina Dalsgaard; Orntoft, Torben Falck; Borre, Michael; Maehle, Lovise; Grindedal, Eli Marie; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Martin, Richard M.; Travis, Ruth C.; Key, Tim J.; Hamilton, Robert J.; Fleshner, Neil E.; Finelli, Antonio; Ingles, Sue Ann; Stern, Mariana C.; Rosenstein, Barry; Kerns, Sarah; Ostrer, Harry; Lu, Yong-Jie; Zhang, Hong-Wei; Feng, Ninghan; Mao, Xueying; Guo, Xin; Wang, Guomin; Sun, Zan; Giles, Graham G.; Southey, Melissa C.; MacInnis, Robert J.; FitzGerald, Liesel M.; Kibel, Adam S.; Drake, Bettina F.; Vega, Ana; Gómez-Caamaño, Antonio; Fachal, Laura; Szulkin, Robert; Eklund, Martin; Kogevinas, Manolis; Llorca, Javier; Castaño-Vinyals, Gemma; Penney, Kathryn L.; Stampfer, Meir; Park, Jong Y.; Sellers, Thomas A.; Lin, Hui-Yi; Stanford, Janet L.; Cybulski, Cezary; Wokolorczyk, Dominika; Lubinski, Jan; Ostrander, Elaine A.; Geybels, Milan S.; Nordestgaard, Børge G.; Nielsen, Sune F.; Weisher, Maren; Bisbjerg, Rasmus; Røder, Martin Andreas; Iversen, Peter; Brenner, Hermann; Cuk, Katarina; Holleczek, Bernd; Maier, Christiane; Luedeke, Manuel; Schnoeller, Thomas; Kim, Jeri; Logothetis, Christopher J.; John, Esther M.; Teixeira, Manuel R.; Paulo, Paula; Cardoso, Marta; Neuhausen, Susan L.; Steele, Linda; Ding, Yuan Chun; De Ruyck, Kim; De Meerleer, Gert; Ost, Piet; Razack, Azad; Lim, Jasmine; Teo, Soo-Hwang; Lin, Daniel W.; Newcomb, Lisa F.; Lessel, Davor; Gamulin, Marija; Kuliš, Tomislav; Kaneva, Radka; Usmani, Nawaid; Slavov, Chavdar; Mitev, Vanio; Parliament, Matthew; Singhal, Sandeep; Claessens, Frank; Joniau, Steven; Van den Broeck, Thomas; Larkin, Samantha; Townsend, Paul A.; Aukim-Hastie, Claire; Gago-Dominguez, Manuela; Castelao, Jose Esteban; Martinez, Maria Elena; Roobol, Monique J.; Jenster, Guido; van Schaik, Ron H. N.; Menegaux, Florence; Truong, Thérèse; Koudou, Yves Akoli; Xu, Jianfeng; Khaw, Kay-Tee; Cannon-Albright, Lisa; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; Thibodeau, Stephen N.; McDonnell, Shannon K.; Schaid, Daniel J.; Lindstrom, Sara; Turman, Constance; Ma, Jing; Hunter, David J.; Riboli, Elio; Siddiq, Afshan; Canzian, Federico; Kolonel, Laurence N.; Le Marchand, Loic; Hoover, Robert N.; Machiela, Mitchell J.; Kraft, Peter; Freedman, Matthew; Wiklund, Fredrik; Chanock, Stephen; Henderson, Brian E.; Easton, Douglas F.; Haiman, Christopher A.; Eeles, Rosalind A.; Conti, David V.; Kote-Jarai, Zsofia

doi:10.1038/s41467-018-04109-8

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Scientific paper - Original scientific paper

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Nature Communications, 9 (2018), 1; 2256. https://doi.org/10.1038/s41467-018-04109-8

Dadaev, Tokhir; Saunders, Edward J.; Newcombe, Paul J.; Anokian, Ezequiel; Leongamornlert, Daniel A.; Brook, Mark N.; Cieza-Borrella, Clara; Mijuskovic, Martina; Wakerell, Sarah; Olama, Ali Amin Al; Schumacher, Fredrick R.; Berndt, Sonja I.; Benlloch, Sara; Ahmed, Mahbubl; Goh, Chee; Sheng, Xin; Zhang, Zhuo; Muir, Kenneth; Govindasami, Koveela; Lophatananon, Artitaya; Stevens, Victoria L.; Gapstur, Susan M.; Carter, Brian D.; Tangen, Catherine M.; Goodman, Phyllis; Thompson, Ian M.; Batra, Jyotsna; Chambers, Suzanne; Moya, Leire; Clements, Judith; Horvath, Lisa; Tilley, Wayne; Risbridger, Gail; Gronberg, Henrik; Aly, Markus; Nordström, Tobias; Pharoah, Paul; Pashayan, Nora; Schleutker, Johanna; Tammela, Teuvo L. J.; Sipeky, Csilla; Auvinen, Anssi; Albanes, Demetrius; Weinstein, Stephanie; Wolk, Alicja; Hakansson, Niclas; West, Catharine; Dunning, Alison M.; Burnet, Neil; Mucci, Lorelei; Giovannucci, Edward; Andriole, Gerald; Cussenot, Olivier; Cancel-Tassin, Géraldine; Koutros, Stella; Freeman, Laura E. Beane; Sorensen, Karina Dalsgaard; Orntoft, Torben Falck; Borre, Michael; Maehle, Lovise; Grindedal, Eli Marie; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Martin, Richard M.; Travis, Ruth C.; Key, Tim J.; Hamilton, Robert J.; Fleshner, Neil E.; Finelli, Antonio; Ingles, Sue Ann; Stern, Mariana C.; Rosenstein, Barry; Kerns, Sarah; Ostrer, Harry; Lu, Yong-Jie; Zhang, Hong-Wei; Feng, Ninghan; Mao, Xueying; Guo, Xin; Wang, Guomin; Sun, Zan; Giles, Graham G.; Southey, Melissa C.; MacInnis, Robert J.; FitzGerald, Liesel M.; Kibel, Adam S.; Drake, Bettina F.; Vega, Ana; Gómez-Caamaño, Antonio; Fachal, Laura; Szulkin, Robert; Eklund, Martin; Kogevinas, Manolis; Llorca, Javier; Castaño-Vinyals, Gemma; Penney, Kathryn L.; Stampfer, Meir; Park, Jong Y.; Sellers, Thomas A.; Lin, Hui-Yi; Stanford, Janet L.; Cybulski, Cezary; Wokolorczyk, Dominika; Lubinski, Jan; Ostrander, Elaine A.; Geybels, Milan S.; Nordestgaard, Børge G.; Nielsen, Sune F.; Weisher, Maren; Bisbjerg, Rasmus; Røder, Martin Andreas; Iversen, Peter; Brenner, Hermann; Cuk, Katarina; Holleczek, Bernd; Maier, Christiane; Luedeke, Manuel; Schnoeller, Thomas; Kim, Jeri; Logothetis, Christopher J.; John, Esther M.; Teixeira, Manuel R.; Paulo, Paula; Cardoso, Marta; Neuhausen, Susan L.; Steele, Linda; Ding, Yuan Chun; De Ruyck, Kim; De Meerleer, Gert; Ost, Piet; Razack, Azad; Lim, Jasmine; Teo, Soo-Hwang; Lin, Daniel W.; Newcomb, Lisa F.; Lessel, Davor; Gamulin, Marija; Kuliš, Tomislav; Kaneva, Radka; Usmani, Nawaid; Slavov, Chavdar; Mitev, Vanio; Parliament, Matthew; Singhal, Sandeep; Claessens, Frank; Joniau, Steven; Van den Broeck, Thomas; Larkin, Samantha; Townsend, Paul A.; Aukim-Hastie, Claire; Gago-Dominguez, Manuela; Castelao, Jose Esteban; Martinez, Maria Elena; Roobol, Monique J.; Jenster, Guido; van Schaik, Ron H. N.; Menegaux, Florence; Truong, Thérèse; Koudou, Yves Akoli; Xu, Jianfeng; Khaw, Kay-Tee; Cannon-Albright, Lisa; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; Thibodeau, Stephen N.; McDonnell, Shannon K.; Schaid, Daniel J.; Lindstrom, Sara; Turman, Constance; Ma, Jing; Hunter, David J.; Riboli, Elio; Siddiq, Afshan; Canzian, Federico; Kolonel, Laurence N.; Le Marchand, Loic; Hoover, Robert N.; Machiela, Mitchell J.; Kraft, Peter; Freedman, Matthew; Wiklund, Fredrik; Chanock, Stephen; Henderson, Brian E.; Easton, Douglas F.; Haiman, Christopher A.; Eeles, Rosalind A.; Conti, David V.; Kote-Jarai, Zsofia More authors...

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

APA 6th Edition

Dadaev, T., Saunders, E. J., Newcombe, P. J., Anokian, E., Leongamornlert, D. A., Brook, M. N. ... Kote Jarai, Z. (2018). Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. Nature Communications, 9. (1), 2256. doi: 10.1038/s41467-018-04109-8

MLA 8th Edition

Dadaev, Tokhir, et al. "Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants." Nature Communications, vol. 9, no. 1, 2018, p. 2256. https://doi.org/10.1038/s41467-018-04109-8

Chicago 17th Edition

Dadaev, Tokhir, Edward J. Saunders, Paul J. Newcombe, Ezequiel Anokian, Daniel A. Leongamornlert, Mark N. Brook, Clara Cieza Borrella, et al. "Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants." Nature Communications 9, no. 1 (2018): 2256. https://doi.org/10.1038/s41467-018-04109-8

Harvard

Dadaev, T., et al. (2018) 'Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants', Nature Communications, 9(1), p. 2256. doi: 10.1038/s41467-018-04109-8

Vancouver

Dadaev T, Saunders EJ, Newcombe PJ, Anokian E, Leongamornlert DA, Brook MN, and sur.. Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. Nature Communications [Internet]. 2018 June 11 [cited 2024 November 22];9(1):2256. doi: 10.1038/s41467-018-04109-8

IEEE

T. Dadaev, et al., "Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants", Nature Communications, vol. 9, no. 1, p. 2256, June 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:746068. [Accessed: 22 November 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:746068

Metadata

Title (english)	Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Author	Tokhir Dadaev
Author	Edward J. Saunders
Author	Paul J. Newcombe
Author	Ezequiel Anokian
Author	Daniel A. Leongamornlert
Author	Mark N. Brook
Author	Clara Cieza-Borrella
Author	Martina Mijuskovic
Author	Sarah Wakerell
Author	Ali Amin Al Olama
Author	Fredrick R. Schumacher
Author	Sonja I. Berndt
Author	Sara Benlloch
Author	Mahbubl Ahmed
Author	Chee Goh
Author	Xin Sheng
Author	Zhuo Zhang
Author	Kenneth Muir
Author	Koveela Govindasami
Author	Artitaya Lophatananon
Author	Victoria L. Stevens
Author	Susan M. Gapstur
Author	Brian D. Carter
Author	Catherine M. Tangen
Author	Phyllis Goodman
Author	Ian M. Thompson
Author	Jyotsna Batra
Author	Suzanne Chambers
Author	Leire Moya
Author	Judith Clements
Author	Lisa Horvath
Author	Wayne Tilley
Author	Gail Risbridger
Author	Henrik Gronberg
Author	Markus Aly
Author	Tobias Nordström
Author	Paul Pharoah
Author	Nora Pashayan
Author	Johanna Schleutker
Author	Teuvo L. J. Tammela
Author	Csilla Sipeky
Author	Anssi Auvinen
Author	Demetrius Albanes
Author	Stephanie Weinstein
Author	Alicja Wolk
Author	Niclas Hakansson
Author	Catharine West
Author	Alison M. Dunning
Author	Neil Burnet
Author	Lorelei Mucci
Author	Edward Giovannucci
Author	Gerald Andriole
Author	Olivier Cussenot
Author	Géraldine Cancel-Tassin
Author	Stella Koutros
Author	Laura E. Beane Freeman
Author	Karina Dalsgaard Sorensen
Author	Torben Falck Orntoft
Author	Michael Borre
Author	Lovise Maehle
Author	Eli Marie Grindedal
Author	David E. Neal
Author	Jenny L. Donovan
Author	Freddie C. Hamdy
Author	Richard M. Martin
Author	Ruth C. Travis
Author	Tim J. Key
Author	Robert J. Hamilton
Author	Neil E. Fleshner
Author	Antonio Finelli
Author	Sue Ann Ingles
Author	Mariana C. Stern
Author	Barry Rosenstein
Author	Sarah Kerns
Author	Harry Ostrer
Author	Yong-Jie Lu
Author	Hong-Wei Zhang
Author	Ninghan Feng
Author	Xueying Mao
Author	Xin Guo
Author	Guomin Wang
Author	Zan Sun
Author	Graham G. Giles
Author	Melissa C. Southey
Author	Robert J. MacInnis
Author	Liesel M. FitzGerald
Author	Adam S. Kibel
Author	Bettina F. Drake
Author	Ana Vega
Author	Antonio Gómez-Caamaño
Author	Laura Fachal
Author	Robert Szulkin
Author	Martin Eklund
Author	Manolis Kogevinas
Author	Javier Llorca
Author	Gemma Castaño-Vinyals
Author	Kathryn L. Penney
Author	Meir Stampfer
Author	Jong Y. Park
Author	Thomas A. Sellers
Author	Hui-Yi Lin
Author	Janet L. Stanford
Author	Cezary Cybulski
Author	Dominika Wokolorczyk
Author	Jan Lubinski
Author	Elaine A. Ostrander
Author	Milan S. Geybels
Author	Børge G. Nordestgaard
Author	Sune F. Nielsen
Author	Maren Weisher
Author	Rasmus Bisbjerg
Author	Martin Andreas Røder
Author	Peter Iversen
Author	Hermann Brenner
Author	Katarina Cuk
Author	Bernd Holleczek
Author	Christiane Maier
Author	Manuel Luedeke
Author	Thomas Schnoeller
Author	Jeri Kim
Author	Christopher J. Logothetis
Author	Esther M. John
Author	Manuel R. Teixeira
Author	Paula Paulo
Author	Marta Cardoso
Author	Susan L. Neuhausen
Author	Linda Steele
Author	Yuan Chun Ding
Author	Kim De Ruyck
Author	Gert De Meerleer
Author	Piet Ost
Author	Azad Razack
Author	Jasmine Lim
Author	Soo-Hwang Teo
Author	Daniel W. Lin
Author	Lisa F. Newcomb
Author	Davor Lessel
Author	Marija Gamulin
Author	Tomislav Kuliš
Author	Radka Kaneva
Author	Nawaid Usmani
Author	Chavdar Slavov
Author	Vanio Mitev
Author	Matthew Parliament
Author	Sandeep Singhal
Author	Frank Claessens
Author	Steven Joniau
Author	Thomas Van den Broeck
Author	Samantha Larkin
Author	Paul A. Townsend
Author	Claire Aukim-Hastie
Author	Manuela Gago-Dominguez
Author	Jose Esteban Castelao
Author	Maria Elena Martinez
Author	Monique J. Roobol
Author	Guido Jenster
Author	Ron H. N. van Schaik
Author	Florence Menegaux
Author	Thérèse Truong
Author	Yves Akoli Koudou
Author	Jianfeng Xu
Author	Kay-Tee Khaw
Author	Lisa Cannon-Albright
Author	Hardev Pandha
Author	Agnieszka Michael
Author	Andrzej Kierzek
Author	Stephen N. Thibodeau
Author	Shannon K. McDonnell
Author	Daniel J. Schaid
Author	Sara Lindstrom
Author	Constance Turman
Author	Jing Ma
Author	David J. Hunter
Author	Elio Riboli
Author	Afshan Siddiq
Author	Federico Canzian
Author	Laurence N. Kolonel
Author	Loic Le Marchand
Author	Robert N. Hoover
Author	Mitchell J. Machiela
Author	Peter Kraft
Author	Matthew Freedman
Author	Fredrik Wiklund
Author	Stephen Chanock
Author	Brian E. Henderson
Author	Douglas F. Easton
Author	Christopher A. Haiman
Author	Rosalind A. Eeles
Author	David V. Conti
Author	Zsofia Kote-Jarai
Author's institution	University of Zagreb School of Medicine
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract (english)	Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	Nature Communications
Numbering	vol. 9, no. 1, p. 2256
p-ISSN	2041-1723
DOI	https://doi.org/10.1038/s41467-018-04109-8
URN:NBN	urn:nbn:hr:105:746068
Publication	2018-06-11
Document URL	https://doi.org/10.1038/s41467-018-04109-8
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2024-03-28 10:02:10

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