prikaz prve stranice dokumenta Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
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Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Nature Communications, 9 (2018), 1; 2256. https://doi.org/10.1038/s41467-018-04109-8
Dadaev, Tokhir; Saunders, Edward J.; Newcombe, Paul J.; Anokian, Ezequiel; Leongamornlert, Daniel A.; Brook, Mark N.; Cieza-Borrella, Clara; Mijuskovic, Martina; Wakerell, Sarah; Olama, Ali Amin Al; Schumacher, Fredrick R.; Berndt, Sonja I.; Benlloch, Sara; Ahmed, Mahbubl; Goh, Chee; Sheng, Xin; Zhang, Zhuo; Muir, Kenneth; Govindasami, Koveela; Lophatananon, Artitaya; Stevens, Victoria L.; Gapstur, Susan M.; Carter, Brian D.; Tangen, Catherine M.; Goodman, Phyllis; Thompson, Ian M.; Batra, Jyotsna; Chambers, Suzanne; Moya, Leire; Clements, Judith; Horvath, Lisa; Tilley, Wayne; Risbridger, Gail; Gronberg, Henrik; Aly, Markus; Nordström, Tobias; Pharoah, Paul; Pashayan, Nora; Schleutker, Johanna; Tammela, Teuvo L. J.; Sipeky, Csilla; Auvinen, Anssi; Albanes, Demetrius; Weinstein, Stephanie; Wolk, Alicja; Hakansson, Niclas; West, Catharine; Dunning, Alison M.; Burnet, Neil; Mucci, Lorelei; Giovannucci, Edward; Andriole, Gerald; Cussenot, Olivier; Cancel-Tassin, Géraldine; Koutros, Stella; Freeman, Laura E. Beane; Sorensen, Karina Dalsgaard; Orntoft, Torben Falck; Borre, Michael; Maehle, Lovise; Grindedal, Eli Marie; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Martin, Richard M.; Travis, Ruth C.; Key, Tim J.; Hamilton, Robert J.; Fleshner, Neil E.; Finelli, Antonio; Ingles, Sue Ann; Stern, Mariana C.; Rosenstein, Barry; Kerns, Sarah; Ostrer, Harry; Lu, Yong-Jie; Zhang, Hong-Wei; Feng, Ninghan; Mao, Xueying; Guo, Xin; Wang, Guomin; Sun, Zan; Giles, Graham G.; Southey, Melissa C.; MacInnis, Robert J.; FitzGerald, Liesel M.; Kibel, Adam S.; Drake, Bettina F.; Vega, Ana; Gómez-Caamaño, Antonio; Fachal, Laura; Szulkin, Robert; Eklund, Martin; Kogevinas, Manolis; Llorca, Javier; Castaño-Vinyals, Gemma; Penney, Kathryn L.; Stampfer, Meir; Park, Jong Y.; Sellers, Thomas A.; Lin, Hui-Yi; Stanford, Janet L.; Cybulski, Cezary; Wokolorczyk, Dominika; Lubinski, Jan; Ostrander, Elaine A.; Geybels, Milan S.; Nordestgaard, Børge G.; Nielsen, Sune F.; Weisher, Maren; Bisbjerg, Rasmus; Røder, Martin Andreas; Iversen, Peter; Brenner, Hermann; Cuk, Katarina; Holleczek, Bernd; Maier, Christiane; Luedeke, Manuel; Schnoeller, Thomas; Kim, Jeri; Logothetis, Christopher J.; John, Esther M.; Teixeira, Manuel R.; Paulo, Paula; Cardoso, Marta; Neuhausen, Susan L.; Steele, Linda; Ding, Yuan Chun; De Ruyck, Kim; De Meerleer, Gert; Ost, Piet; Razack, Azad; Lim, Jasmine; Teo, Soo-Hwang; Lin, Daniel W.; Newcomb, Lisa F.; Lessel, Davor; Gamulin, Marija; Kuliš, Tomislav; Kaneva, Radka; Usmani, Nawaid; Slavov, Chavdar; Mitev, Vanio; Parliament, Matthew; Singhal, Sandeep; Claessens, Frank; Joniau, Steven; Van den Broeck, Thomas; Larkin, Samantha; Townsend, Paul A.; Aukim-Hastie, Claire; Gago-Dominguez, Manuela; Castelao, Jose Esteban; Martinez, Maria Elena; Roobol, Monique J.; Jenster, Guido; van Schaik, Ron H. N.; Menegaux, Florence; Truong, Thérèse; Koudou, Yves Akoli; Xu, Jianfeng; Khaw, Kay-Tee; Cannon-Albright, Lisa; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; Thibodeau, Stephen N.; McDonnell, Shannon K.; Schaid, Daniel J.; Lindstrom, Sara; Turman, Constance; Ma, Jing; Hunter, David J.; Riboli, Elio; Siddiq, Afshan; Canzian, Federico; Kolonel, Laurence N.; Le Marchand, Loic; Hoover, Robert N.; Machiela, Mitchell J.; Kraft, Peter; Freedman, Matthew; Wiklund, Fredrik; Chanock, Stephen; Henderson, Brian E.; Easton, Douglas F.; Haiman, Christopher A.; Eeles, Rosalind A.; Conti, David V.; Kote-Jarai, Zsofia Više autora...

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Dadaev, T., Saunders, E. J., Newcombe, P. J., Anokian, E., Leongamornlert, D. A., Brook, M. N. ... Kote Jarai, Z. (2018). Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. Nature Communications, 9. (1), 2256. doi: 10.1038/s41467-018-04109-8

Dadaev, Tokhir, et al. "Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants." Nature Communications, vol. 9, br. 1, 2018, str. 2256. https://doi.org/10.1038/s41467-018-04109-8

Dadaev, Tokhir, Edward J. Saunders, Paul J. Newcombe, Ezequiel Anokian, Daniel A. Leongamornlert, Mark N. Brook, Clara Cieza Borrella, et al. "Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants." Nature Communications 9, br. 1 (2018): 2256. https://doi.org/10.1038/s41467-018-04109-8

Dadaev, T., et al. (2018) 'Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants', Nature Communications, 9(1), str. 2256. doi: 10.1038/s41467-018-04109-8

Dadaev T, Saunders EJ, Newcombe PJ, Anokian E, Leongamornlert DA, Brook MN, i sur.. Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. Nature Communications [Internet]. 11.06.2018. [pristupljeno 25.12.2024.];9(1):2256. doi: 10.1038/s41467-018-04109-8

T. Dadaev, et al., "Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants", Nature Communications, vol. 9, br. 1, str. 2256, Lipanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:746068. [Citirano: 25.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:746068
Podaci o radu
Naslov (engleski)Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
AutorTokhir Dadaev
AutorEdward J. Saunders
AutorPaul J. Newcombe
AutorEzequiel Anokian
AutorDaniel A. Leongamornlert
AutorMark N. Brook
AutorClara Cieza-Borrella
AutorMartina Mijuskovic
AutorSarah Wakerell
AutorAli Amin Al Olama
AutorFredrick R. Schumacher
AutorSonja I. Berndt
AutorSara Benlloch
AutorMahbubl Ahmed
AutorChee Goh
AutorXin Sheng
AutorZhuo Zhang
AutorKenneth Muir
AutorKoveela Govindasami
AutorArtitaya Lophatananon
AutorVictoria L. Stevens
AutorSusan M. Gapstur
AutorBrian D. Carter
AutorCatherine M. Tangen
AutorPhyllis Goodman
AutorIan M. Thompson
AutorJyotsna Batra
AutorSuzanne Chambers
AutorLeire Moya
AutorJudith Clements
AutorLisa Horvath
AutorWayne Tilley
AutorGail Risbridger
AutorHenrik Gronberg
AutorMarkus Aly
AutorTobias Nordström
AutorPaul Pharoah
AutorNora Pashayan
AutorJohanna Schleutker
AutorTeuvo L. J. Tammela
AutorCsilla Sipeky
AutorAnssi Auvinen
AutorDemetrius Albanes
AutorStephanie Weinstein
AutorAlicja Wolk
AutorNiclas Hakansson
AutorCatharine West
AutorAlison M. Dunning
AutorNeil Burnet
AutorLorelei Mucci
AutorEdward Giovannucci
AutorGerald Andriole
AutorOlivier Cussenot
AutorGéraldine Cancel-Tassin
AutorStella Koutros
AutorLaura E. Beane Freeman
AutorKarina Dalsgaard Sorensen
AutorTorben Falck Orntoft
AutorMichael Borre
AutorLovise Maehle
AutorEli Marie Grindedal
AutorDavid E. Neal
AutorJenny L. Donovan
AutorFreddie C. Hamdy
AutorRichard M. Martin
AutorRuth C. Travis
AutorTim J. Key
AutorRobert J. Hamilton
AutorNeil E. Fleshner
AutorAntonio Finelli
AutorSue Ann Ingles
AutorMariana C. Stern
AutorBarry Rosenstein
AutorSarah Kerns
AutorHarry Ostrer
AutorYong-Jie Lu
AutorHong-Wei Zhang
AutorNinghan Feng
AutorXueying Mao
AutorXin Guo
AutorGuomin Wang
AutorZan Sun
AutorGraham G. Giles
AutorMelissa C. Southey
AutorRobert J. MacInnis
AutorLiesel M. FitzGerald
AutorAdam S. Kibel
AutorBettina F. Drake
AutorAna Vega
AutorAntonio Gómez-Caamaño
AutorLaura Fachal
AutorRobert Szulkin
AutorMartin Eklund
AutorManolis Kogevinas
AutorJavier Llorca
AutorGemma Castaño-Vinyals
AutorKathryn L. Penney
AutorMeir Stampfer
AutorJong Y. Park
AutorThomas A. Sellers
AutorHui-Yi Lin
AutorJanet L. Stanford
AutorCezary Cybulski
AutorDominika Wokolorczyk
AutorJan Lubinski
AutorElaine A. Ostrander
AutorMilan S. Geybels
AutorBørge G. Nordestgaard
AutorSune F. Nielsen
AutorMaren Weisher
AutorRasmus Bisbjerg
AutorMartin Andreas Røder
AutorPeter Iversen
AutorHermann Brenner
AutorKatarina Cuk
AutorBernd Holleczek
AutorChristiane Maier
AutorManuel Luedeke
AutorThomas Schnoeller
AutorJeri Kim
AutorChristopher J. Logothetis
AutorEsther M. John
AutorManuel R. Teixeira
AutorPaula Paulo
AutorMarta Cardoso
AutorSusan L. Neuhausen
AutorLinda Steele
AutorYuan Chun Ding
AutorKim De Ruyck
AutorGert De Meerleer
AutorPiet Ost
AutorAzad Razack
AutorJasmine Lim
AutorSoo-Hwang Teo
AutorDaniel W. Lin
AutorLisa F. Newcomb
AutorDavor Lessel
AutorMarija Gamulin
AutorTomislav Kuliš
AutorRadka Kaneva
AutorNawaid Usmani
AutorChavdar Slavov
AutorVanio Mitev
AutorMatthew Parliament
AutorSandeep Singhal
AutorFrank Claessens
AutorSteven Joniau
AutorThomas Van den Broeck
AutorSamantha Larkin
AutorPaul A. Townsend
AutorClaire Aukim-Hastie
AutorManuela Gago-Dominguez
AutorJose Esteban Castelao
AutorMaria Elena Martinez
AutorMonique J. Roobol
AutorGuido Jenster
AutorRon H. N. van Schaik
AutorFlorence Menegaux
AutorThérèse Truong
AutorYves Akoli Koudou
AutorJianfeng Xu
AutorKay-Tee Khaw
AutorLisa Cannon-Albright
AutorHardev Pandha
AutorAgnieszka Michael
AutorAndrzej Kierzek
AutorStephen N. Thibodeau
AutorShannon K. McDonnell
AutorDaniel J. Schaid
AutorSara Lindstrom
AutorConstance Turman
AutorJing Ma
AutorDavid J. Hunter
AutorElio Riboli
AutorAfshan Siddiq
AutorFederico Canzian
AutorLaurence N. Kolonel
AutorLoic Le Marchand
AutorRobert N. Hoover
AutorMitchell J. Machiela
AutorPeter Kraft
AutorMatthew Freedman
AutorFredrik Wiklund
AutorStephen Chanock
AutorBrian E. Henderson
AutorDouglas F. Easton
AutorChristopher A. Haiman
AutorRosalind A. Eeles
AutorDavid V. Conti
AutorZsofia Kote-Jarai
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 9, br. 1, str. 2256
p-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-018-04109-8
URN:NBNurn:nbn:hr:105:746068
Datum objave publikacije2018-06-11
URL dokumentahttps://doi.org/10.1038/s41467-018-04109-8
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:02:10