prikaz prve stranice dokumenta Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy
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Scientific paper - Original scientific paper
Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy
Frontiers in Cardiovascular Medicine, 5 (2018); 166. https://doi.org/doi:10.3389/fcvm.2018.00166
Premužić, Vedran; Ivković, Vanja; Leko, Ninoslav; Stipančić, Želimir; Karanović, Sandra; Jelaković, Ana; Vuković Brinar, Ivana; Dika, Živka; Jelaković, Bojan

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Premužić, V., Ivković, V., Leko, N., Stipančić, Ž., Karanović, S., Jelaković, A. ... Jelaković, B. (2018). Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy. Frontiers in Cardiovascular Medicine, 5., 166. doi: doi:10.3389/fcvm.2018.00166

Premužić, Vedran, et al. "Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy." Frontiers in Cardiovascular Medicine, vol. 5, 2018, p. 166. https://doi.org/doi:10.3389/fcvm.2018.00166

Premužić, Vedran, Vanja Ivković, Ninoslav Leko, Želimir Stipančić, Sandra Karanović, Ana Jelaković, Ivana Vuković Brinar, Živka Dika and Bojan Jelaković. "Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy." Frontiers in Cardiovascular Medicine 5 (2018): 166. https://doi.org/doi:10.3389/fcvm.2018.00166

Premužić, V., et al. (2018) 'Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy', Frontiers in Cardiovascular Medicine, 5, p. 166. doi: doi:10.3389/fcvm.2018.00166

Premužić V, Ivković V, Leko N, Stipančić Ž, Karanović S, Jelaković A, and sur.. Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy. Frontiers in Cardiovascular Medicine [Internet]. 2018 November 15 [cited 2024 April 28];5:166. doi: doi:10.3389/fcvm.2018.00166

V. Premužić, et al., "Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy", Frontiers in Cardiovascular Medicine, vol. 5, p. 166, November 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:796095. [Accessed: 28 April 2024]

Metadata
Title (english)Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy
AuthorVedran Premužić
AuthorVanja Ivković
AuthorNinoslav Leko
AuthorŽelimir Stipančić
AuthorSandra Karanović
AuthorAna Jelaković
AuthorIvana Vuković Brinar
AuthorŽivka Dika
AuthorBojan Jelaković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (croatian)
Balkan endemic nephropathy (BEN), an environmental form of aristolochic acid nephropathy is characterized with later onset and milder forms of hypertension (HT). Thus, we hypothesized that arterial stiffness progresses slower in BEN patients resulting in lower CV mortality. A total of 186 hemodialysed (HD) patients (90 BEN, 96 non-BEN; 67.3 + 13.0 years) were enrolled and followed-up for 25 months. Brachial blood pressure (BP) and pulse wave velocity (PWV) were determined before mid-week dialysis. BEN patients were older (72.1 ± 37.1 vs. 62.8 ± 15.1; p < 0.001), had shorter duration of HT prior commencement of HD than non-BEN patients (36 vs. 84 months; p < 0.001). There were no differences in BP, but BEN patients were treated with less antihypertensive drugs (p < 0.01). BEN patients had lower PWV values at baseline and at the end of follow-up period despite being chronologically older (p < 0.001). Baseline PWV > 10 m/s was associated with higher risk for CV mortality (aHR 1.8 [1.4, 2.4]). In multivariate analyses BEN was predictor of lower PWV. During the follow-up period significantly less CV deaths were observed in BEN vs. on-BEN patients (12 vs. 31; p = 0.001). CV mortality adjusted for other risk factors was significantly lower in BEN group (aHR 0.2 [0.1, 0.5]). Overall BEN patients had longer mean survival time on HD (22.3 vs. 18.2 months; p < 0.001). Observed slower vascular aging (i.e., lower PWV) in BEN patients compared to other ESRD patients is related to the later onset of HT and milder stages of HT during predialytic clinical course and better control of BP and phosphate during HD.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFrontiers in Cardiovascular Medicine
Numberingvol. 5, p. 166
p-ISSN2297-055X
DOIhttps://doi.org/doi:10.3389/fcvm.2018.00166
URN:NBNurn:nbn:hr:105:796095
Publication2018-11-15
Document URLhttp://doi.org/10.3389/fcvm.2018.00166
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:02:37