prikaz prve stranice dokumenta Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy
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Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy
Frontiers in Cardiovascular Medicine, 5 (2018); 166. https://doi.org/doi:10.3389/fcvm.2018.00166
Premužić, Vedran; Ivković, Vanja; Leko, Ninoslav; Stipančić, Želimir; Karanović, Sandra; Jelaković, Ana; Vuković Brinar, Ivana; Dika, Živka; Jelaković, Bojan

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Premužić, V., Ivković, V., Leko, N., Stipančić, Ž., Karanović, S., Jelaković, A. ... Jelaković, B. (2018). Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy. Frontiers in Cardiovascular Medicine, 5., 166. doi: doi:10.3389/fcvm.2018.00166

Premužić, Vedran, et al. "Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy." Frontiers in Cardiovascular Medicine, vol. 5, 2018, str. 166. https://doi.org/doi:10.3389/fcvm.2018.00166

Premužić, Vedran, Vanja Ivković, Ninoslav Leko, Želimir Stipančić, Sandra Karanović, Ana Jelaković, Ivana Vuković Brinar, Živka Dika i Bojan Jelaković. "Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy." Frontiers in Cardiovascular Medicine 5 (2018): 166. https://doi.org/doi:10.3389/fcvm.2018.00166

Premužić, V., et al. (2018) 'Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy', Frontiers in Cardiovascular Medicine, 5, str. 166. doi: doi:10.3389/fcvm.2018.00166

Premužić V, Ivković V, Leko N, Stipančić Ž, Karanović S, Jelaković A, i sur.. Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy. Frontiers in Cardiovascular Medicine [Internet]. 15.11.2018. [pristupljeno 17.02.2025.];5:166. doi: doi:10.3389/fcvm.2018.00166

V. Premužić, et al., "Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy", Frontiers in Cardiovascular Medicine, vol. 5, str. 166, Studeni 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:796095. [Citirano: 17.02.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:796095
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Naslov (engleski)Arterial stiffness in Balkan endemic nephropathy, an environmental form of aristolochic acid nephropathy
AutorVedran Premužić
AutorVanja Ivković
AutorNinoslav Leko
AutorŽelimir Stipančić
AutorSandra Karanović
AutorAna Jelaković
AutorIvana Vuković Brinar
AutorŽivka Dika
AutorBojan Jelaković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (hrvatski)
Balkan endemic nephropathy (BEN), an environmental form of aristolochic acid nephropathy is characterized with later onset and milder forms of hypertension (HT). Thus, we hypothesized that arterial stiffness progresses slower in BEN patients resulting in lower CV mortality. A total of 186 hemodialysed (HD) patients (90 BEN, 96 non-BEN; 67.3 + 13.0 years) were enrolled and followed-up for 25 months. Brachial blood pressure (BP) and pulse wave velocity (PWV) were determined before mid-week dialysis. BEN patients were older (72.1 ± 37.1 vs. 62.8 ± 15.1; p < 0.001), had shorter duration of HT prior commencement of HD than non-BEN patients (36 vs. 84 months; p < 0.001). There were no differences in BP, but BEN patients were treated with less antihypertensive drugs (p < 0.01). BEN patients had lower PWV values at baseline and at the end of follow-up period despite being chronologically older (p < 0.001). Baseline PWV > 10 m/s was associated with higher risk for CV mortality (aHR 1.8 [1.4, 2.4]). In multivariate analyses BEN was predictor of lower PWV. During the follow-up period significantly less CV deaths were observed in BEN vs. on-BEN patients (12 vs. 31; p = 0.001). CV mortality adjusted for other risk factors was significantly lower in BEN group (aHR 0.2 [0.1, 0.5]). Overall BEN patients had longer mean survival time on HD (22.3 vs. 18.2 months; p < 0.001). Observed slower vascular aging (i.e., lower PWV) in BEN patients compared to other ESRD patients is related to the later onset of HT and milder stages of HT during predialytic clinical course and better control of BP and phosphate during HD.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Cardiovascular Medicine
Brojčani podacivol. 5, str. 166
p-ISSN2297-055X
DOIhttps://doi.org/doi:10.3389/fcvm.2018.00166
URN:NBNurn:nbn:hr:105:796095
Datum objave publikacije2018-11-15
URL dokumentahttp://doi.org/10.3389/fcvm.2018.00166
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:02:37