prikaz prve stranice dokumenta Comparable genomic copy number aberrations differ across astrocytoma malignancy grades
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Scientific paper - Original scientific paper
Comparable genomic copy number aberrations differ across astrocytoma malignancy grades
International Journal of Molecular Sciences, 20 (2019), 5; 1251. https://doi.org/10.3390/ijms20051251
Pećina-Šlaus, Nives; Kafka, Anja; Gotovac Jerčić, Kristina; Logara, Monika; Bukovac, Anja; Bakarić, Robert; Borovečki, Fran

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Pećina Šlaus, N., Kafka, A., Gotovac Jerčić, K., Logara, M., Bukovac, A., Bakarić, R. & Borovečki, F. (2019). Comparable genomic copy number aberrations differ across astrocytoma malignancy grades. International Journal of Molecular Sciences, 20. (5), 1251. doi: 10.3390/ijms20051251

Pećina Šlaus, Nives, et al. "Comparable genomic copy number aberrations differ across astrocytoma malignancy grades." International Journal of Molecular Sciences, vol. 20, no. 5, 2019, p. 1251. https://doi.org/10.3390/ijms20051251

Pećina Šlaus, Nives, Anja Kafka, Kristina Gotovac Jerčić, Monika Logara, Anja Bukovac, Robert Bakarić and Fran Borovečki. "Comparable genomic copy number aberrations differ across astrocytoma malignancy grades." International Journal of Molecular Sciences 20, no. 5 (2019): 1251. https://doi.org/10.3390/ijms20051251

Pećina Šlaus, N., et al. (2019) 'Comparable genomic copy number aberrations differ across astrocytoma malignancy grades', International Journal of Molecular Sciences, 20(5), p. 1251. doi: 10.3390/ijms20051251

Pećina Šlaus N, Kafka A, Gotovac Jerčić K, Logara M, Bukovac A, Bakarić R, and sur.. Comparable genomic copy number aberrations differ across astrocytoma malignancy grades. International Journal of Molecular Sciences [Internet]. 2019 March 12 [cited 2024 October 12];20(5):1251. doi: 10.3390/ijms20051251

N. Pećina Šlaus, et al., "Comparable genomic copy number aberrations differ across astrocytoma malignancy grades", International Journal of Molecular Sciences, vol. 20, no. 5, p. 1251, March 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:647655. [Accessed: 12 October 2024]

Metadata
Title (english)Comparable genomic copy number aberrations differ across astrocytoma malignancy grades
AuthorNives Pećina-Šlaus
AuthorAnja Kafka
AuthorKristina Gotovac Jerčić
AuthorMonika Logara
AuthorAnja Bukovac
AuthorRobert Bakarić
AuthorFran Borovečki
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
A collection of intracranial astrocytomas of different malignancy grades was analyzed for copy number aberrations (CNA) in order to identify regions that are driving cancer pathogenesis. Astrocytomas were analyzed by Array Comparative Genomic Hybridization (aCGH) and bioinformatics utilizing a Bioconductor package, Genomic Identification of Significant Targets in Cancer (GISTIC) 2.0.23 and DAVID software. Altogether, 1438 CNA were found of which losses prevailed. On our total sample, significant deletions affected 14 chromosomal regions, out of which deletions at 17p13.2, 9p21.3, 13q12.11, 22q12.3 remained significant even at 0.05 q-value. When divided into malignancy groups, the regions identified as significantly deleted in high grades were: 9p21.3; 17p13.2; 10q24.2; 14q21.3; 1p36.11 and 13q12.11, while amplified were: 3q28; 12q13.3 and 21q22.3. Low grades comprised significant deletions at 3p14.3; 11p15.4; 15q15.1; 16q22.1; 20q11.22 and 22q12.3 indicating their involvement in early stages of tumorigenesis. Significantly enriched pathways were: PI3K-Akt, Cytokine-cytokine receptor, the nucleotide-binding oligomerization domain (NOD)–like receptor, Jak-STAT, retinoic acid-inducible gene (RIG)-I-like receptor and Toll-like receptor pathways. HPV and herpex simplex infection and inflammation pathways were also represented. The present study brings new data to astrocytoma research amplifying the wide spectrum of changes that could help us identify the regions critical for tumorigenesis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 20, no. 5, p. 1251
p-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms20051251
URN:NBNurn:nbn:hr:105:647655
Publication2019-03-12
Document URLhttp://doi.org/10.3390/ijms20051251
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:26:04