prikaz prve stranice dokumenta Comparable genomic copy number aberrations differ across astrocytoma malignancy grades
  Preuzmi
PDF 2.8 MB
Znanstveni rad - Izvorni znanstveni rad
Comparable genomic copy number aberrations differ across astrocytoma malignancy grades
International Journal of Molecular Sciences, 20 (2019), 5; 1251. https://doi.org/10.3390/ijms20051251
Pećina-Šlaus, Nives; Kafka, Anja; Gotovac Jerčić, Kristina; Logara, Monika; Bukovac, Anja; Bakarić, Robert; Borovečki, Fran

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Pećina Šlaus, N., Kafka, A., Gotovac Jerčić, K., Logara, M., Bukovac, A., Bakarić, R. i Borovečki, F. (2019). Comparable genomic copy number aberrations differ across astrocytoma malignancy grades. International Journal of Molecular Sciences, 20. (5), 1251. doi: 10.3390/ijms20051251

Pećina Šlaus, Nives, et al. "Comparable genomic copy number aberrations differ across astrocytoma malignancy grades." International Journal of Molecular Sciences, vol. 20, br. 5, 2019, str. 1251. https://doi.org/10.3390/ijms20051251

Pećina Šlaus, Nives, Anja Kafka, Kristina Gotovac Jerčić, Monika Logara, Anja Bukovac, Robert Bakarić i Fran Borovečki. "Comparable genomic copy number aberrations differ across astrocytoma malignancy grades." International Journal of Molecular Sciences 20, br. 5 (2019): 1251. https://doi.org/10.3390/ijms20051251

Pećina Šlaus, N., et al. (2019) 'Comparable genomic copy number aberrations differ across astrocytoma malignancy grades', International Journal of Molecular Sciences, 20(5), str. 1251. doi: 10.3390/ijms20051251

Pećina Šlaus N, Kafka A, Gotovac Jerčić K, Logara M, Bukovac A, Bakarić R, i sur.. Comparable genomic copy number aberrations differ across astrocytoma malignancy grades. International Journal of Molecular Sciences [Internet]. 12.03.2019. [pristupljeno 23.12.2024.];20(5):1251. doi: 10.3390/ijms20051251

N. Pećina Šlaus, et al., "Comparable genomic copy number aberrations differ across astrocytoma malignancy grades", International Journal of Molecular Sciences, vol. 20, br. 5, str. 1251, Ožujak 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:647655. [Citirano: 23.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:647655
Podaci o radu
Naslov (engleski)Comparable genomic copy number aberrations differ across astrocytoma malignancy grades
AutorNives Pećina-Šlaus
AutorAnja Kafka
AutorKristina Gotovac Jerčić
AutorMonika Logara
AutorAnja Bukovac
AutorRobert Bakarić
AutorFran Borovečki
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
A collection of intracranial astrocytomas of different malignancy grades was analyzed for copy number aberrations (CNA) in order to identify regions that are driving cancer pathogenesis. Astrocytomas were analyzed by Array Comparative Genomic Hybridization (aCGH) and bioinformatics utilizing a Bioconductor package, Genomic Identification of Significant Targets in Cancer (GISTIC) 2.0.23 and DAVID software. Altogether, 1438 CNA were found of which losses prevailed. On our total sample, significant deletions affected 14 chromosomal regions, out of which deletions at 17p13.2, 9p21.3, 13q12.11, 22q12.3 remained significant even at 0.05 q-value. When divided into malignancy groups, the regions identified as significantly deleted in high grades were: 9p21.3; 17p13.2; 10q24.2; 14q21.3; 1p36.11 and 13q12.11, while amplified were: 3q28; 12q13.3 and 21q22.3. Low grades comprised significant deletions at 3p14.3; 11p15.4; 15q15.1; 16q22.1; 20q11.22 and 22q12.3 indicating their involvement in early stages of tumorigenesis. Significantly enriched pathways were: PI3K-Akt, Cytokine-cytokine receptor, the nucleotide-binding oligomerization domain (NOD)–like receptor, Jak-STAT, retinoic acid-inducible gene (RIG)-I-like receptor and Toll-like receptor pathways. HPV and herpex simplex infection and inflammation pathways were also represented. The present study brings new data to astrocytoma research amplifying the wide spectrum of changes that could help us identify the regions critical for tumorigenesis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 20, br. 5, str. 1251
p-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms20051251
URN:NBNurn:nbn:hr:105:647655
Datum objave publikacije2019-03-12
URL dokumentahttp://doi.org/10.3390/ijms20051251
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:26:04