prikaz prve stranice dokumenta MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas
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Scientific paper - Original scientific paper
MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas
Pathology International, 57 (2007), 1; 47-51. https://doi.org/doi: 10.1111/j.1440-1827.2007.02056.x
Borovečki, Ana; Korać, Petra; Ventura, Roland A.; Milković Periša, Marija; Banham, Alison H.; Dominis, Mara

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Borovečki, A., Korać, P., Ventura, R. A., Milković Periša, M., Banham, A. H. & Dominis, M. (2007). MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas. Pathology International, 57. (1), 47-51. doi: doi: 10.1111/j.1440-1827.2007.02056.x

Borovečki, Ana, et al. "MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas." Pathology International, vol. 57, no. 1, 2007, pp. 47-51. https://doi.org/doi: 10.1111/j.1440-1827.2007.02056.x

Borovečki, Ana, Petra Korać, Roland A. Ventura, Marija Milković Periša, Alison H. Banham and Mara Dominis. "MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas." Pathology International 57, no. 1 (2007): 47-51. https://doi.org/doi: 10.1111/j.1440-1827.2007.02056.x

Borovečki, A., et al. (2007) 'MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas', Pathology International, 57(1), pp. 47-51. doi: doi: 10.1111/j.1440-1827.2007.02056.x

Borovečki A, Korać P, Ventura RA, Milković Periša M, Banham AH, Dominis M. MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas. Pathology International [Internet]. 2007 January [cited 2024 November 29];57(1):47-51. doi: doi: 10.1111/j.1440-1827.2007.02056.x

A. Borovečki, P. Korać, R. A. Ventura, M. Milković Periša, A. H. Banham and M. Dominis, "MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas", Pathology International, vol. 57, no. 1, pp. 47-51, January 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:125763. [Accessed: 29 November 2024]

Metadata
Title (english)MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas
AuthorAna Borovečki
AuthorPetra Korać
AuthorRoland A. Ventura
AuthorMarija Milković Periša
AuthorAlison H. Banham
AuthorMara Dominis
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
In view of the certain anatomic site-dependent frequency of chromosomal translocations involved in extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) pathogenesis, 17 salivary gland MALT lymphoma cases were analyzed for MALT1 and FOXP1 translocations. B cell CLL/lymphoma 10 (BCL10) and forkhead box PA (FOXP1) protein expression were studied by immunohistochemistry and translocations identified using fluorescence in situ hybridization (FISH)-specific probes FOXP1, t(11;18)(q21;q21)/API2-MALT1 and t(14;18)(q32;q21)/IgH-MALT1. None of the 11 analyzed cases showed FOXP1 rearrangement or amplification. The t(11;18) was present in five of 13 cases and the t(14;18) in three of 13 cases. MALT1 translocations were mostly mutually exclusive except in a single case. FOXP1 protein expression showed differences in the proportion of tumor cells with nuclear expression but not in their intensity, with the exception of one case where very intense nuclear staining was noted. BCL10 nuclear expression was present in four of 17 cases, two of which lacked t(11;18). Our results suggest that MALT1-specific translocations and FOXP1 rearrangements are not commonly involved in pathogenesis. A case with strong FOXP1 protein expression indicates the possibility that the upregulation of FOXP1 expression is significant in a small subset of salivary gland MALT lymphomas. Also a single case in which both MALT1 translocations were present indicates that these are not always mutually exclusive.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePathology International
Numberingvol. 57, no. 1, pp. 47-51
p-ISSN1320-5463
DOIhttps://doi.org/doi: 10.1111/j.1440-1827.2007.02056.x
URN:NBNurn:nbn:hr:105:125763
Publication2007-01
Document URLhttps://doi.org/10.1111/j.1440-1827.2007.02056.x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:28:24